Grant Awards

Grant Awards

Members of the University of Louisville Department of Medicine are working hard in labs and clinics producing novel and groundbreaking research to benefit the health and well-being of the world community.

Updated March 29, 2019

Researchers in Roman labThose efforts require the financial means to continue toward the goal of making the world a better place through breakthroughs in research.

While certain grant funding makes headlines, all is vital in the mission to advance the knowledge of clinicians and care-givers to better treat their patients and help them live their lives to the fullest.

We congratulate the members of our department whose hard work, dedication and curiosity make it possible to move forward in those quests.

(Source: UofL Today Recent Awards "Snapshot" updates)


March 2019

 

Principal Investigator

Division

Sponsor

Title

Amount

 

Marcin Wysoczynski, Ph.D.

Cardiovascular Medicine

National Institutes of Health

The Role of Bioactive Lipids in CMC-induced Myocardial Repair

$385,000


February 2019

 

Principal Investigator

Division

Sponsor

Title

Amount

 

Sanjay Srivastava, Ph.D.

Cardiovascular Medicine

Children's Hospital Boston

Molecular Regulation of Atherosclerosis

$169,400


January 2019

 

Principal Investigator

Division

Sponsor

Title

Amount

 

Aruni Bhatnagar, Ph.D.

Cardiovascular Medicine

National American Heart Association

ATRAC 2.0 - American Heart Association Tobacco Regulatory Science Center

$1,736,930


Previous Years

December 2018

Principal Investigator

Division

Sponsor

Title

Amount

Jerry Yu, Ph.D.

Pulmonary

V.A. Medical Center

Xia Yu IPA Agreement

$78,281


November 2018

Principal Investigator

Division

Sponsor

Title

Amount

Jason Chesney, M.D., Ph.D.

Oncology/
Hematology

Ky. Council on Postsecondary Ed

FY2019 & FY2020 - Cancer Research and Screening

$6,843,250

Ky. Council on Postsecondary Ed

FY2019 & FY2020 - Cancer Research Inst. Matching

$4,110,000

American Cancer Society

JGBCC M Krista Loyd Resource Center Transportation Fund

$15,000

Jon Klein, M.D., Ph.D.

Nephrology/
Hypertension

Jewish Heritage Fund

JHFE Research Enhancement Grants

$600,000

Jewish Heritage Fund

JHFE Research Recruitment

$600,000

Shirish Barve, Ph.D.

Gastroenterology

National Institutes of Health

Role of Gut Microbial Dysbiosis and Aging on HIV-Associated Neurocognitive and Brain Dysfunction

$779,748


October 2018

Principal Investigator

Division

Sponsor

Title

Amount

Eleanor Lederer, M.D.

Nephrology/
Hypertension

V.A. Medical Center

Michelle Barati IPA

$22,821

Craig McClain, M.D.

Gastroenterology

National Institutes of Health

Alcoholic Hepatitis Network 3/9 University of Louisville

$369,000


September 2018

Principal Investigator

Division

Sponsor

Title

Amount

Jason Chesney, M.D., Ph.D.

Oncology/
Hematology

Ky. Cabinet for Health & Family Services

FY19 & FY20 Adult Hemophilia Clinics

$30,000

Paul Bates, Ph.D.

Oncology/
Hematology

National Science Foundation

PFI-RP: Development of Delivery Devices to Enable Cell Transformation or Preservation

$750,000

Petra Haberzettl, Ph.D.

Cardiovascular Medicine

National Institutes of Health

Effects of Air Pollution on Stem Cell Health

$456,275

Jason Hellmann, Ph.D.

Cardiovascular Medicine

National Institutes of Health

Exercise-enhanced Resolution of Inflammation

$462,462


August 2018

Principal Investigator

Division

Sponsor

Title

Amount

Paula Bates, Ph.D.

Oncology/
Hematology

U.S. Department of Defense

Combining Immunotherapy with Nanoparticles for Improved Kidney Cancer Outcomes

$115,500

Zhong-bin Deng, Ph.D.

Oncology/
Hematology

National Institutes of Health

Gut Extracellular Vesicles Promote Alcohol-Induced Liver Injury via TLR4-Regulated miRNAs

$221,375

National Institutes of Health

CSN8 Regulation of S1P-Enriched Extracellular Vesicles to Modulate NAFLD by Gut-Liver Axis

$415,800

Jerry Yu, Ph.D.

Pulmonary

V.A. Medical Center

IPA Agreement - Igor Zelko (Yu PULM-024-17S The Vagus Nerve in Lung Disease)

$112,036

V.A. Medical Center

IPA Agreement - Lu Cai (Yu PULM-024-17S The Vagus Nerve in Lung Disease)

$19,276


July 2018

Principal Investigator

Division

Sponsor

Title

Amount

Aruni Bhatnagar, Ph.D.

Cardiovascular Medicine

National Institutes of Health

COBRE - Center for Excellence in Diabetes and Obesity Research

$1,115,000

The Nature Conservancy

Green Heart Project

$2,000,000


June 2018

Principal Investigator

Division

Sponsor

Title

Amount

Levi Beverly, Ph.D.

Oncology/
Hematology

Kentucky Lung Cancer Research Program

Understanding the Role of Gamma Secretase and Ubiquilin in Antigen Processing, Interferon Signaling and Immunotherapy

$75,000

Ruth Carrico, Ph.D.

Infectious Diseases

Kentucky Department for Public Health

UofL Ebola Stimulus FY19

$170,000

Howard Donninger, Ph.D.

Oncology/
Hematology

Kentucky Lung Cancer Research Program

Overcoming Lung Cancer MDSC-mediated Immune Suppression by Targeting IL-6 Signaling

$75,000

Chi Li, Ph.D.

Oncology/
Hematology

Kentucky Lung Cancer Research Program

Inhibit Non-Small Cell Lung Cancer Growth by Targeting Paraoxonase 2

$75,000


March 2018

Principal Investigator

Division

Sponsor

Title

Amount

Joseph Moore IV, Ph.D.

Cardiovascular Medicine

National Institutes of Health

The Role of Cardiomyogenic Lineage Commitment in Cardiac Mesenchymal Cell-Mediated Extracellular Vesicle Signaling and Cardiac Repair

$385,000

Timothy O'Toole, Ph.D.

Cardiovascular Medicine

National Institutes of Health

Endothelial Progenitor Cells and Particulate Air Pollution

$624,022


February 2018

Principal Investigator

Division

Sponsor

Title

Amount

Shirish Barve, Ph.D.

Gastroenterology

Vanderbilt University

1/2 Alcohol Associated Comorbidities and Microbiome Evaluation in HIV (ACME HIV)

$289,851


January 2018

Principal Investigator

Division

Sponsor

Title

Amount

Ruth Carrico, Ph.D., RN

Infectious Diseases

Catholic Charities

Refugee Health Surveillance

$30,000

Jon Klein, M.D., Ph.D.

Nephrology/
Hypertension

Jewish Heritage Fund

Jewish Heritage Fund for Excellence Research Enhancement Grant

$347,385

November 2017

Principal Investigator

Division

Sponsor

Title

Amount

Shirish Barve, Ph.D.

Gastroenterology

National Institutes of Health

2/2 Alcohol Associated Comorbidities and Microbiome Evaluation in HIV (ACME HIV)

$673,788

Matthew Cave, M.D.

Gastroenterology

National Institutes of Health

Environmental Liver Disease

$550,876


October 2017

Principal Investigator

Division

Sponsor

Title

Amount

Roberto Bolli, M.D.

Cardiovascular Medicine

National Institutes of Health

Protection of Ischemic Myocardium

$2,774,979

Sanjay Srivastava, Ph.D.

Cardiovascular Medicine

National Institutes of Health

Environmental Exposure and Cardiometabolic Disease - Admin Core

$1,335,021


September 2017

Principal Investigator

Division

Sponsor

Title

Amount

Jonathan Chaires, Ph.D.

Oncology/
Hematology

National Institutes of Health

Targeting Nucleic Acids with an Integrated Virtual and Actual Screen

$355,395

Craig McClain, M.D.

Gastroenterology

VA Medical Center

IPA-Lanceta CSP#577 CONFIRM VA Cooperative Study

$35,587


August 2017

Principal Investigator

Division

Sponsor

Title

Amount

Sanjay Srivastava, Ph.D.

Cardiovascular Medicine

University of Texas Medical Branch

Using Fortilin Inhibitors to Block Atherosclerosis

$123,200

Children's Hospital Boston

Molecular Mechanisms Regulating Endothelial Dysfunction

$200,200

Jun Yan, Ph.D.

Oncology/
Hematology

National Psoriasis Foundation

Regulation of Innate Gammadelta T17 Cells in Skin Inflammation

$100,000


July 2017

Principal Investigator

Division

Sponsor

Title

Amount

Steven Jones, Ph.D.

Cardiovascular Medicine

National American Heart Association

Louisville Cardiovascular Mentorship Program: Developing Independent Cardiovascular Investigators

$60,000

Zhong-bin Deng, Ph.D.

Oncology/
Hematology

National Institutes of Health

Intestinal Epithelial Cells-Derived Exosomal miRNA's Regulate Liver Inflammation in Obesity

$231,000

Mariusz Ratajczak, M.D., Ph.D.

Oncology/
Hematology

National Institutes of Health

Novel Mechanisms Involving Complement Cascade in Stem Cell Trafficking

$346,500


June 2017

Principal Investigator

Division

Sponsor

Title

Amount

Nichola Garbett, Ph.D.

Oncology/
Hematology

Wake Forest University

Theranostic Nanoparticles for Detection and Treatment of Pancreatic Cancer

$3,186

Wake Forest University

Stroma Targeted Theranostic Nanoparticles for Pancreatic Cancer

$5,461

Kavitha Yaddanapudi, M.D., Ph.D.

Oncology/
Hematology

Kentucky Lung Cancer Research Program

A Novel Immunotherapeutic Approach for the Treatment of Lung Cancer

$150,000

Mariusz Ratajczak, M.D., Ph.D.

Oncology/
Hematology

National Institutes of Health

Current Trends in Stem Cell Therapies

$128,751

Mark Rothstein, J.D.

Internal Medicine

National Institutes of Health

Addressing ELSI Issues in Unregulated Health Research Using Mobile Devices

$676,565


May 2017

Principal Investigator

Division

Sponsor

Title

Amount

Nichola Garbett, Ph.D.

Oncology/
Hematology

National Institutes of Health

Enhanced Diagnostic Assessment in Lupus Using Differential Scanning Calorimetry

$360,517

Petra Haberzettl, Ph.D.

Cardiovascular Medicine

National Institutes of Health

Air Pollution, Circadian Rhythm Disruption and Cardiometabolic Disease

$344,607


April 2017

Principal Investigator

Division

Sponsor

Title

Amount

Julio Ramirez, M.D.

Infectious Diseases

National Institutes of Health

Clinical and Translational Research in Pneumonia: Creating a Research Agenda for Today and Tomorrow

$5,000

John Trent, Ph.D.

Oncology/
Hematology

Kentucky Lung Cancer Research Program

Targeting the Human Telomere Complex in Lung Cancer

$150,000

Jun Yan, M.D., Ph.D.

Oncology/
Hematology

National Institutes of Health

Regulation of Dermal Gamma Delta T Cells by Pathogens/Microbial Commensals in Health and Psoriasis

$200,000


March 2017

Principal Investigator

Division

Sponsor

Title

Amount

Mark Pfiefer, M.D.

Internal Medicine

National Institutes of Health

Training in Interprofessional Education for Palliative Care in Oncology

$203,380

Craig McClain, M.D.

Gastroenterology

VA Medical Center

IPA - Mahanes - Dietary Fat & Alcoholic Liver Disease

$130,727

VA Medical Center

IPA - Warner - Dietary Fat & Alcoholic Liver Disease

$84,778

VA Medical Center

IPA - Mir-CSP#577 Confirm VA Cooperative Study

$123,854

Jon Klein, M.D., Ph.D.

Nephrology/
Hypertension

Nationwide Children's Hospital

Integrating Proteomics and Metabolomics to Understand Pediatric Glomerular Disease Pathophysiology and Prognosis

$250,784


February 2017

Principal Investigator

Division

Sponsor

Title

Amount

Jun Yan, Ph.D.

Oncology/
Hematology

National Institutes of Health

Transcriptional Regulation of Immunosupressive Macrophages by c-Maf in Cancer

$352,275


January 2017

Principal Investigator

Division

Sponsor

Title

Amount

Monica Ann Shaw, M.D.

Internal Medicine

Commonwealth of Kentucky

Trover Rural Scholarships for Class 2017 and 2018

$1,406,000

Vincent La Russa, Ph.D.

Cardiovascular Medicine

Indiana University

Stem Cell Manufacturing to Support STL16101Q Champ Pilot Study

$69,900

December 2016

Principal Investigator

Division

Sponsor

Title

Amount

Barbara Head, Ph.D., RN

Internal Medicine

Gordon and Betty Moore Foundation

Palliative and Hospice Social Worker Certification

$289,382


November 2016

Principal Investigator

Division

Sponsor

Title

Amount

Lacey McNally, Ph.D.

Oncology/
Hematology

National Institutes of Health

Theranostic Nanoparticles for Detection and Treatment of Pancreatic Cancer

$390,388


September 2016

Principal Investigator

Division

Sponsor

Title

Amount

Barbara Head, Ph.D., RN

Internal Medicine

Hospice and Palliative Nurses Foundation

Work and Compassion Satisfaction, Burnout and Secondary Trauma Among Hospice and Palliative Nurses: Does Certification Make a Difference?

$14,926

Paula Bates, Ph.D.

Oncology/
Hematology

Jewish Heritage Fund

New Approaches to Overcome Malignant Brain Tumors

$112,670

Thomas Abell, M.D.

Gastroenterology

National Institutes of Health

University of Louisville's Clinical Center in Gastroparesis Clinical Research Consortium

$383,920

Ruth Carrico, Ph.D., RN

Infectious Diseases

Catholic Charities

Refugee Health Promotion

$19,244

Shirish Barve, Ph.D.

Gastroenterology

National Institutes of Health

Role of Gut Microbiome and DHA Deficiency in Alcohol Induced Neuroinflammation

$337,500


August 2016

Principal Investigator

Division

Sponsor

Title

Amount

Madhavi Rane, Ph.D.

Nephrology

Johns Hopkins University

Targeting Divergent Roles of Caspase 3 to Promote Endothelial Barrier Integrity

$30,800

Matthew Nystoriak, Ph.D.

Cardiovascular Medicine

American Heart Association - Great Rivers Affiliate

Compartmentalized Camp Signaling in Diabetic Vascular Dysfunction

$77,000

Jerry Yu, Ph.D.

Pulmonary

Pulmonary Fibrosis Foundation

The Vagus Nerve in Pulmonary Fibrosis

$50,000

Donald Miller, M.D., Ph.D.

Oncology/
Hematology

Kentucky Cabinet for Health & Family Services

Y17 Adult Hemophilia Clinics

$15,000

Kentucky Council on Postsecondary Education

Kentucky Lung Cancer Research Program - Administration

$3,718,600

Kentucky Council on Postsecondary Education

Tobacco Tax Funding-Cancer Research Institute Matching FY17-18

$4,110,000

Lacey McNalley, Ph.D.

Oncology/
Hematology

National Institutes of Health

Non-invasive Detection of Tumor Extracellular pH Using Multispectral Optoacoustic Tomography

$350,293


July 2016

Principal Investigator

Division

Sponsor

Title

Amount

A. Gregory Deam, M.D.

Cardiovascular Medicine

Boston Scientific Corproation

Clinical Cardiac Electrophysiology Fellowship Program

$25,000

Medtronic, Inc.

Clinical Cardiac Electrophysiology Fellowship Program

$30,000

Umair Gauhar, M.D.

Pulmonary

Veracyte, Inc.

Percepta R-1 :Respective Registry to Evaluate Percepta Bronchial Genomic Classifier Patient Data: The PERCEPTA Registry

$1,888

Veracyte, Inc.

Bronchial Sample Collection for a Novel Genomic Test-3

$68,380.37

Craig McClain, M.D.

Gastroenterology

National Institutes of Health

Novel Therapies In Alcoholic Hepatitis University of Louisville

$261,000

National Institutes of Health

Mechanisms for Alcohol Induced Gut Barrier Dysfunction in ALD

$322,818

National Institutes of Health

Hepatobiology and Toxicology COBRE - Administrative Core

$2,608,500

Donald Miller, M.D., Ph.D.

Oncology/
Hematology

National Institutes of Health

Molecular Targets CoBRE Phase III - Core A

$1,052,312

Sanjay Srivastava, Ph.D.

Cardiovascular Medicine

National American Heart Association

ATRAC -CORE A - Adminstration

$86,169

Aruni Bhatnagar, Ph.D.

Cardiovascular Medicine

National Institutes of Health

COBRE - Administrative Core

$2,250,000

Paula Peyrani, M.D.

Infectious Diseases

Health Resources and Services Administration

University of Louisville HIV Early Interventions Service (EIS Program)

$333,918

Kentucky Department for Public Health

FEDERAL FY17-18 KHCCP - UofL 550 Clinic

$2,026,382

Kentucky Department for Public Health

STATE FY17-18 KHCCP - UofL 550 Clinic

$1,198,680

Kavitha Yaddanapudi, Ph.D.

Oncology/
Hematology

National Institutes of Health

A Novel Vaccination Stratagem for Lung Cancer

$163,125

Shirish Barve, Ph.D.

Gastroenterology

National Institutes of Health

SAM Deficiency Mediated Epigenetic Mechanisms in Alcohol Induced Immunosuppression - Supplement

$100,000

Irina Kirpich, Ph.D.

Gastroenterology

National Institutes of Health

The Role of Dietary Unsaturated Fat and Inflammasome in Alcoholic Liver Disease

$346,500

Andrew Gibb

Cardiovascular Medicine

American Heart Association - Great Rivers Affiliate

Metabolic Regulation of Myocardial Adaptations to Exercise

$51,900

Xian-Liang Tang, M.D.

Cardiovascular Medicine

EndoProtech, Inc.

A Novel Lipotherapy to Reduce Infarct Size Following Myocardial Infarction

$69,253