William W. Tse, M.D., FACP

William Tse, M.D., FACP

William W. Tse, M.D., FACP

James Graham Brown Cancer Center
529 South Jackson Street
Louisville, KY 40202
502-562-3367- Academic Office
502-562-4543- Patient Appointments


Clinical Expertise
Blood and Bone Marrow Transplantation


Education and Training

  • Medical School: Sun Yat-Sen University School of Medicine
  • Residency: Sun Yat-Sen University Cancer Center (Surgery); North Shore-Long Island Jewish Health Care System (Internal Medicine)
  • Fellowship: Fred Hutchinson Cancer Research Center; University of Washington Medical Center

Featured Publications

  • Ma G, Shen J, Pinz K, Wada M, Park J, Kim S, Togano T, Tse W. Targeting T Cell Malignancies Using CD4CAR T-Cells and Implementing a Natural Safety Switch. Stem Cell Rev. 2019 Mar 2. doi: 10.1007/s12015-019-09876-5. [Epub ahead of print] PubMed PMID: 30826931.
  • Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discov. 2018 Nov;8(11):1438-1457. doi: 10.1158/2159-8290.CD-17-1203. Epub 2018 Aug 23. PubMed PMID: 30139811.
  • Ratajczak MZ, Adamiak M, Kucia M, Tse W, Ratajczak J, Wiktor-Jedrzejczak W. The Emerging Link Between the Complement Cascade and Purinergic Signaling in Stress Hematopoiesis. Front Immunol. 2018 Jun 5;9:1295. doi: 10.3389/fimmu.2018.01295. eCollection 2018. Review. PubMed PMID: 29922299; PubMed Central PMCID: PMC5996046.
  • Hashmi H, Murray D, Al-Quran S, Tse W. Primary Effusion Lymphoma without an Effusion: A Rare Case of Solid Extracavitary Variant of Primary Effusion Lymphoma in an HIV-Positive Patient. Case Rep Hematol. 2018 Jan 28;2018:9368451. doi: 10.1155/2018/9368451. eCollection 2018. PubMed PMID: 29619259; PubMed Central PMCID: PMC5829335.
  • Pinz KG, Yakaboski E, Jares A, Liu H, Firor AE, Chen KH, Wada M, Salman H, Tse W, Hagag N, Lan F, Leung EL, Jiang X, Ma Y. Targeting T-cell malignancies using anti-CD4 CAR NK-92 cells. Oncotarget. 2017 Nov 22;8(68):112783-112796. doi: 10.18632/oncotarget.22626. eCollection 2017 Dec 22. PubMed PMID: 29348865; PubMed Central PMCID: PMC5762550.
  • Sabnis HS, Bradley HL, Tripathi S, Yu WM, Tse W, Qu CK, Bunting KD. Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine. Leuk Res. 2016 Nov;50:132-140. doi: 10.1016/j.leukres.2016.10.004. Epub 2016 Oct 5. PubMed PMID: 27760406; PubMed Central PMCID: PMC5083204.
  • Chi A, Wen S, Monga M, Almubarak M, He X, Rojanasakul Y, Tse W, Remick SC. Definitive Upfront Stereotactic Ablative Radiotherapy Combined with Image-Guided, Intensity Modulated Radiotherapy (IG-IMRT) or IG-IMRT Alone for Locally Advanced Non-Small Cell Lung Cancer. PLoS One. 2016 Sep 9;11(9):e0162453. doi: 10.1371/journal.pone.0162453. eCollection 2016. PubMed PMID: 27611833; PubMed Central PMCID: PMC5017732.
  • Park J, Kim S, Joh J, Remick SC, Miller DM, Yan J, Kanaan Z, Chao JH, Krem MM, Basu SK, Hagiwara S, Kenner L, Moriggl R, Bunting KD, Tse W. MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling. Oncotarget. 2016 Jul 12;7(28):43960-43973. doi: 10.18632/oncotarget.9759. PubMed PMID: 27259262; PubMed Central PMCID: PMC5190071.
  • Claudino WM, Gibson B, Tse W, Krem M, Grewal J. Methotrexate-associated primary cutaneous CD30-positive cutaneous T-cell lymphoproliferative disorder: a case illustration and a brief review. Am J Blood Res. 2016 May 18;6(1):1-5. eCollection 2016. PubMed PMID: 27335685; PubMed Central PMCID: PMC4913234.
  • Park J, Schlederer M, Schreiber M, Ice R, Merkel O, Bilban M, Hofbauer S, Kim S, Addison J, Zou J, Ji C, Bunting ST, Wang Z, Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick S, Ivanov A, Pugacheva E, Bunting KD, Moriggl R, Kenner L, Tse W. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget. 2015 Aug 21;6(24):20697-710. PubMed PMID: 26079538; PubMed Central PMCID: PMC4653036.