Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

  • Professor of Medicine and Pharmacology
  • Chief, Division of Medical Oncology and Hematology
  • Director, James Graham Brown Cancer Center
  • James Graham Brown Foundation Chair
James Graham Brown Cancer Center
529 South Jackson Street
Louisville, KY 40202

502-852-2522 - Academic Office
502-562-4370 - Patient Appointments


Clinical Expertise
Head and Neck; Medical Oncology; Skin Cancer; Melanoma

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine

Education and Training

  • Medical School: Duke University
  • Residency: Peter Bent Brigham Hospital (Boston)
  • Fellowship: Harvard University
  • Ph.D.: Duke University

 

Recent Publications

    • Islam MA, Thomas SD, Murty VV, Sedoris KJ, Miller DM. c-Myc Quadruplex-forming Sequence Pu-27 Induces Extensive Damage in Both Telomeric and Nontelomeric Regions of DNA. J Biol Chem. 2014 Mar 21;289(12):8521-31. doi: 10.1074/jbc.M113.505073. Epub 2014 Jan 24. PubMed PMID: 24464582; PubMed Central PMCID: PMC3961676.
    • Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr DA 2nd, Klarer AC, Redman R, Miller DM, Trent JO, Telang S, Chesney J. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther. 2013 Aug;12(8):1461-70. doi: 10.1158/1535-7163.MCT-13-0097. Epub 2013 May 14. PubMed PMID: 23674815; PubMed Central PMCID: PMC3742633.
    • Islam MA, Thomas SD, Sedoris KJ, Slone SP, Alatassi H, Miller DM. Tumor-associated primo vascular system is derived from xenograft, not host. Exp Mol Pathol. 2013 Feb;94(1):84-90. doi: 10.1016/j.yexmp.2012.09.004. Epub 2012 Sep 19. PubMed PMID: 23000426.
    • Miller DM, Thomas SD, Islam A, Muench D, Sedoris K. c-Myc and cancer metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5546-53. doi: 10.1158/1078-0432.CCR-12-0977. PubMed PMID: 23071356; PubMed Central PMCID: PMC3505847.
    • Sedoris KC, Thomas SD, Clarkson CR, Muench D, Islam A, Singh R, Miller DM. Genomic c-Myc quadruplex DNA selectively kills leukemia. Mol Cancer Ther. 2012 Jan;11(1):66-76. doi: 10.1158/1535-7163.MCT-11-0515. Epub 2011 Nov 14. PubMed PMID: 22084162; PubMed Central PMCID: PMC3701457.
    • Telang S, Rasku MA, Clem AL, Carter K, Klarer AC, Badger WR, Milam RA, Rai SN, Pan J, Gragg H, Clem BF, McMasters KM, Miller DM, Chesney J. Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma. BMC Cancer. 2011 Dec 13;11:515. doi: 10.1186/1471-2407-11-515. PubMed PMID: 22165955; PubMed Central PMCID: PMC3293785.
    • Schwartzentruber DJ, Lawson DH, Richards JM, Conry RM, Miller DM, Treisman J, Gailani F, Riley L, Conlon K, Pockaj B, Kendra KL, White RL, Gonzalez R, Kuzel TM, Curti B, Leming PD, Whitman ED, Balkissoon J, Reintgen DS, Kaufman H, Marincola FM, Merino MJ, Rosenberg SA, Choyke P, Vena D, Hwu P. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 2011 Jun 2;364(22):2119-27. doi: 10.1056/NEJMoa1012863. PubMed PMID: 21631324; PubMed  Central PMCID: PMC3517182.
    • Lane AN, Fan TW, Bousamra M 2nd, Higashi RM, Yan J, Miller DM. Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer. OMICS. 2011 Mar;15(3):173-82. doi: 10.1089/omi.2010.0088. Epub 2011 Feb 17. Review. PubMed PMID: 21329461; PubMed Central PMCID: PMC3125551.
    • Sedoris KC, Thomas SD, Miller DM. Hypoxia induces differential translation of enolase/MBP-1. BMC Cancer. 2010 Apr 22;10:157. doi: 10.1186/1471-2407-10-157. PubMed PMID: 20412594; PubMed Central PMCID: PMC2873388.
    • Rabinowits G, Bhupalam L, Miller DM, Kloecker GH, Laber DA. Fixed-dose every-other-week capecitabine and oxaliplatin for refractory squamous cell carcinoma of the head and neck. Am J Med Sci. 2010 Feb;339(2):148-51. doi: 10.1097/MAJ.0b013e3181c4bd91. PubMed PMID: 20087165.