Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

  • Professor of Medicine and Pharmacology
  • Chief, Division of Medical Oncology and Hematology
  • Director, James Graham Brown Cancer Center
  • James Graham Brown Foundation Chair
James Graham Brown Cancer Center
529 South Jackson Street
Louisville, KY 40202

502-852-2522 - Academic Office
502-562-4370 - Patient Appointments


Clinical Expertise
Head and Neck; Medical Oncology; Skin Cancer; Melanoma

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine

Education and Training

  • Medical School: Duke University
  • Residency: Peter Bent Brigham Hospital (Boston)
  • Fellowship: Harvard University
  • Ph.D.: Duke University

 

Recent Publications

      • Sellers K, Fox MP, Bousamra M 2nd, Slone SP, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Deshpande R, Lane AN, Fan TW. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest. 2015 Feb;125(2):687-98. doi: 10.1172/JCI72873. Epub 2015 Jan 20. PubMed PMID: 25607840.
      • Jiang H, Wang P, Li X, Wang Q, Deng ZB, Zhuang X, Mu J, Zhang L, Wang B, Yan J, Miller D, Zhang HG. Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2. Cancer Immunol Res. 2014 Aug;2(8):789-99. doi: 10.1158/2326-6066.CIR-13-0162. Epub 2014 May 6. PubMed PMID: 24801835.
      • Mu J, Zhuang X, Wang Q, Jiang H, Deng ZB, Wang B, Zhang L, Kakar S, Jun Y, Miller D, Zhang HG. Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. Mol Nutr Food Res. 2014 Jul;58(7):1561-73. doi: 10.1002/mnfr.201300729. Epub 2014 May 19. PubMed PMID: 24842810.
      • Jiang H, Wang P, Wang Q, Wang B, Mu J, Zhuang X, Zhang L, Yan J, Miller D, Zhang HG. Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model. Am J Pathol. 2014 May;184(5):1355-68. doi: 10.1016/j.ajpath.2014.01.037. Epub 2014 Mar 27. PubMed PMID: 24681249; PubMed Central PMCID: PMC4005973.
      • Islam MA, Thomas SD, Murty VV, Sedoris KJ, Miller DM. c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telomeric and nontelomeric regions of DNA. J Biol Chem. 2014 Mar 21;289(12):8521-31. doi: 10.1074/jbc.M113.505073. Epub 2014 Jan 24. PubMed PMID: 24464582; PubMed Central PMCID: PMC3961676.
      • Wang B, Zhuang X, Deng ZB, Jiang H, Mu J, Wang Q, Xiang X, Guo H, Zhang L, Dryden G, Yan J, Miller D, Zhang HG. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Mol Ther. 2014 Mar;22(3):522-34. doi: 10.1038/mt.2013.190. Epub 2013 Aug 13. PubMed PMID: 23939022; PubMed Central PMCID: PMC3944329.
      • Chaires JB, Trent JO, Gray RD, Dean WL, Buscaglia R, Thomas SD, Miller DM. An improved model for the hTERT promoter quadruplex. PLoS One. 2014 Dec 19;9(12):e115580. doi: 10.1371/journal.pone.0115580. eCollection 2014. PubMed PMID: 25526084; PubMed Central PMCID: PMC4272262.
      • Kakar SS, Ratajczak MZ, Powell KS, Moghadamfalahi M, Miller DM, Batra SK, Singh SK. Withaferin a alone and in combination with Cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells. PLoS One. 2014 Sep 29;9(9):e107596. doi: 10.1371/journal.pone.0107596. eCollection 2014. PubMed PMID: 25264898; PubMed Central PMCID: PMC4180068.
      • Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr DA 2nd, Klarer AC, Redman R, Miller DM, Trent JO, Telang S, Chesney J. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther. 2013 Aug;12(8):1461-70. doi: 10.1158/1535-7163.MCT-13-0097. Epub 2013 May 14. PubMed PMID: 23674815; PubMed Central PMCID: PMC3742633.
      • Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, Xiang X, Deng ZB, Wang B, Zhang L, Roth M, Welti R, Mobley J, Jun Y, Miller D, Zhang HG. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Mol Ther. 2013 Jul;21(7):1345-57. doi: 10.1038/mt.2013.64. Epub 2013 Jun 11. PubMed PMID: 23752315; PubMed Central PMCID: PMC3702113.