Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

  • Professor of Medicine and Pharmacology
UofL James Graham Brown Cancer Center
529 South Jackson Street
Louisville, KY 40202

502-852-2522 - Academic Office
502-562-4370 - Patient Appointments


Clinical Expertise
Head and Neck; Medical Oncology; Skin Cancer; Melanoma


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine

Education and Training

  • Medical School: Duke University
  • Residency: Peter Bent Brigham Hospital (Boston)
  • Fellowship: Harvard University
  • Ph.D.: Duke University

Featured Publications

  • Muench D, Rezzoug F, Thomas SD, Xiao J, Islam A, Miller DM, Sedoris KC. Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells. PLoS One. 2019 Jan 25;14(1):e0211046. doi: 10.1371/journal.pone.0211046. eCollection 2019. PubMed PMID: 30682194; PubMed Central PMCID: PMC6347295.
  • Gill A, Gosain R, Gragg H, Bycroft R, Rai SN, Pan J, Chesney JA, Miller DM. 5-(3,3-Dimethyle-1-Triazeno) Imidazole-4-Carboxamide and Interleukin-2 Adjuvant Therapy in Resected High-Risk Primary and Regionally Metastatic Melanoma. Am J Med Sci. 2019 Jan;357(1):43-48. doi: 10.1016/j.amjms.2018.10.009. Epub 2018 Oct 25. PubMed PMID: 30611319.
  • Teng Y, Ren Y, Sayed M, Hu X, Lei C, Kumar A, Hutchins E, Mu J, Deng Z, Luo C, Sundaram K, Sriwastva MK, Zhang L, Hsieh M, Reiman R, Haribabu B, Yan J, Jala VR, Miller DM, Van Keuren-Jensen K, Merchant ML, McClain CJ, Park JW, Egilmez NK, Zhang HG. Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota. Cell Host Microbe. 2018 Nov 14;24(5):637-652.e8. doi: 10.1016/j.chom.2018.10.001. Epub 2018 Oct 25. PubMed PMID: 30449315.
  • Bamji-Stocke S, van Berkel V, Miller DM, Frieboes HB. A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment. Metabolomics. 2018 Jun;14(6):81. doi: 10.1007/s11306-018-1376-2. Epub 2018 Jun 1. PubMed PMID: 29983671; PubMed Central PMCID: PMC6033515.
  • Sharma VR, Thomas SD, Miller DM, Rezzoug F. Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411. Cancer Invest. 2018;36(9-10):475-491. doi: 10.1080/07357907.2018.1527930. Epub 2018 Nov 5. PubMed PMID: 30396283; PubMed Central PMCID: PMC6396827.
  • Kini A, Fu R, Compton C, Miller DM, Ramasubramanian A. Pembrolizumab for Recurrent Conjunctival Melanoma. JAMA Ophthalmol. 2017 Aug 1;135(8):891-892. doi: 10.1001/jamaophthalmol.2017.2279. PubMed PMID: 28715523.
  • Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, Yan J, Miller DM, Zhang HG. MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nat Commun. 2017 Feb 17;8:14448. doi: 10.1038/ncomms14448. PubMed PMID: 28211508; PubMed Central PMCID: PMC5321731.
  • Ratajczak MZ, Ratajczak J, Suszynska M, Miller DM, Kucia M, Shin DM. A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells. Circ Res. 2017 Jan 6;120(1):166-178. doi: 10.1161/CIRCRESAHA.116.309362. Review. PubMed PMID: 28057792; PubMed Central PMCID: PMC5221475.
  • Chariker JH, Miller DM, Rouchka EC. Computational Analysis of G-Quadruplex Forming Sequences across Chromosomes Reveals High Density Patterns Near the Terminal Ends. PLoS One. 2016 Oct 24;11(10):e0165101. doi: 10.1371/journal.pone.0165101. eCollection 2016. PubMed PMID: 27776185; PubMed Central PMCID: PMC5077116.
  • Rezzoug F, Thomas SD, Rouchka EC, Miller DM. Discovery of a Family of Genomic Sequences Which Interact Specifically with the c-MYC Promoter to Regulate c-MYC Expression. PLoS One. 2016 Aug 23;11(8):e0161588. doi: 10.1371/journal.pone.0161588. eCollection 2016. PubMed PMID: 27551915; PubMed Central PMCID: PMC4995011.