Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D.

  • Professor of Medicine and Pharmacology
  • Chief, Division of Medical Oncology and Hematology
  • Director, James Graham Brown Cancer Center
  • James Graham Brown Foundation Chair
James Graham Brown Cancer Center
529 South Jackson Street
Louisville, KY 40202

502-852-2522 - Academic Office
502-562-4370 - Patient Appointments


Clinical Expertise
Head and Neck; Medical Oncology; Skin Cancer; Melanoma

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine

Education and Training

  • Medical School: Duke University
  • Residency: Peter Bent Brigham Hospital (Boston)
  • Fellowship: Harvard University
  • Ph.D.: Duke University

 

Recent Publications

        • Deng Z, Mu J, Tseng M, Wattenberg B, Zhuang X, Egilmez NK, Wang Q, Zhang L, Norris J, Guo H, Yan J, Haribabu B, Miller D, Zhang HG. Corrigendum: Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. Nat Commun. 2016 Apr 11;7:11348. doi: 10.1038/ncomms11348. PubMed PMID: 27063505.
        • Teng Y, Mu J, Hu X, Samykutty A, Zhuang X, Deng Z, Zhang L, Cao P, Yan J, Miller D, Zhang HG. Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages. Oncotarget. 2016 Mar 25. doi: 10.18632/oncotarget.8361. [Epub ahead of print] PubMed PMID: 27028860.
        • Zhuang X, Teng Y, Samykutty A, Mu J, Deng Z, Zhang L, Cao P, Rong Y, Yan J, Miller D, Zhang HG. Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression. Mol Ther. 2016 Feb;24(1):96-105. doi: 10.1038/mt.2015.188. Epub 2015 Oct 7. PubMed PMID: 26444082; PubMed Central PMCID: PMC4754550.
        • Wang Q, Ren Y, Mu J, Egilmez NK, Zhuang X, Deng Z, Zhang L, Yan J, Miller D, Zhang HG. Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites. Cancer Res. 2015 Jun 15;75(12):2520-9. doi: 10.1158/0008-5472.CAN-14-3095. Epub 2015 Apr 16. PubMed PMID: 25883092; PubMed Central PMCID: PMC4470740.
        • Deng Z, Mu J, Tseng M, Wattenberg B, Zhuang X, Egilmez NK, Wang Q, Zhang L, Norris J, Guo H, Yan J, Haribabu B, Miller D, Zhang HG. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis. Nat Commun. 2015 Apr 24;6:6956. doi: 10.1038/ncomms7956. PubMed PMID: 25907800; PubMed Central PMCID: PMC4410277.
        • Sellers K, Fox MP, Bousamra M 2nd, Slone SP, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Deshpande R, Lane AN, Fan TW. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest. 2015 Feb;125(2):687-98. doi: 10.1172/JCI72873. Epub 2015 Jan 20. PubMed PMID: 25607840; PubMed Central PMCID: PMC4319441.
        • Zhuang X, Deng ZB, Mu J, Zhang L, Yan J, Miller D, Feng W, McClain CJ, Zhang HG. Ginger-derived nanoparticles protect against alcohol-induced liver damage. J Extracell Vesicles. 2015 Nov 25;4:28713. doi: 10.3402/jev.v4.28713. eCollection 2015. PubMed PMID: 26610593; PubMed Central PMCID: PMC4662062.
        • Jiang H, Wang P, Li X, Wang Q, Deng ZB, Zhuang X, Mu J, Zhang L, Wang B, Yan J, Miller D, Zhang HG. Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2. Cancer Immunol Res. 2014 Aug;2(8):789-99. doi: 10.1158/2326-6066.CIR-13-0162. Epub 2014 May 6. PubMed PMID: 24801835; PubMed Central PMCID: PMC4396632.
        • Mu J, Zhuang X, Wang Q, Jiang H, Deng ZB, Wang B, Zhang L, Kakar S, Jun Y, Miller D, Zhang HG. Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. Mol Nutr Food Res. 2014 Jul;58(7):1561-73. doi: 10.1002/mnfr.201300729. Epub 2014 May 19. Erratum in: Mol Nutr Food Res. 2016 Apr;60(4):964. PubMed PMID: 24842810.
        • Jiang H, Wang P, Wang Q, Wang B, Mu J, Zhuang X, Zhang L, Yan J, Miller D, Zhang HG. Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model. Am J Pathol. 2014 May;184(5):1355-68. doi: 10.1016/j.ajpath.2014.01.037. Epub 2014 Mar 27. PubMed PMID: 24681249; PubMed Central PMCID: PMC4005973.