Kenneth R. McLeish, M.D., FACP

Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D., FACP

  • Professor of Medicine
VA Medical Center
800 Zorn Avenue
Louisville, KY 40206

502-852-5757- Academic Office
502-287-4000 - VAMC


Clinical Expertise
Nephrology; Lupus Nephritis; Glomerulonephritis


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

Education and Training

  • Medical School: Indiana University
  • Residency: Indiana University Medical Center
  • Fellowship: Indiana University Medical Center

Featured Publications

  • Catz SD, McLeish KR. Therapeutic targeting of neutrophil exocytosis. J Leukoc Biol. 2020 Mar;107(3):393-408. doi: 10.1002/JLB.3RI0120-645R. Epub 2020 Jan 28. Review. PubMed PMID: 31990103; PubMed Central PMCID: PMC7044074.
  • Singel KL, Emmons TR, Khan ANH, Mayor PC, Shen S, Wong JT, Morrell K, Eng KH, Mark J, Bankert RB, Matsuzaki J, Koya RC, Blom AM, McLeish KR, Qu J, Ram S, Moysich KB, Abrams SI, Odunsi K, Zsiros E, Segal BH. Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment. JCI Insight. 2019 Mar 7;4(5). pii: 122311. doi: 10.1172/jci.insight.122311. eCollection 2019 Mar 7. PubMed PMID: 30730851; PubMed Central PMCID: PMC6483507.
  • Caster DJ, Korte EA, Tan M, Barati MT, Tandon S, Creed TM, Salant DJ, Hata JL, Epstein PN, Huang H, Powell DW, McLeish KR. Neutrophil exocytosis induces podocyte cytoskeletal reorganization and proteinuria in experimental glomerulonephritis. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F595-F606. doi: 10.1152/ajprenal.00039.2018. Epub 2018 May 23. PubMed PMID: 29790391; PubMed Central PMCID: PMC6172569.
  • Kartha V, Franco L, Coventry S, McLeish K, Caster DJ, Schadt CR. Hepatitis C mixed cryoglobulinemia with undetectable viral load: A case series. JAAD Case Rep. 2018 Aug 15;4(7):684-687. doi: 10.1016/j.jdcr.2018.04.004. eCollection 2018 Aug. PubMed PMID: 30128338; PubMed Central PMCID: PMC6098195.
  • Merchant ML, Brier ME, Slaughter MS, Klein JB, McLeish KR. Biomarker enhanced risk prediction for development of AKI after cardiac surgery. BMC Nephrol. 2018 May 2;19(1):102. doi: 10.1186/s12882-018-0902-9. PubMed PMID: 29720115; PubMed Central PMCID: PMC5930948.
  • Korte EA, Caster DJ, Barati MT, Tan M, Zheng S, Berthier CC, Brosius FC 3rd, Vieyra MB, Sheehan RM, Kosiewicz M, Wysoczynski M, Gaffney PM, Salant DJ, McLeish KR, Powell DW. ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation. Am J Pathol. 2017 Dec;187(12):2799-2810. doi: 10.1016/j.ajpath.2017.08.018. Epub 2017 Sep 19. PubMed PMID: 28935578; PubMed Central PMCID: PMC5718094.
  • Creed TM, Tandon S, Ward RA, McLeish KR. Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils. Inflamm Res. 2017 Oct;66(10):891-899. doi: 10.1007/s00011-017-1070-2. Epub 2017 Jun 21. PubMed PMID: 28638979.
  • Caster DJ, Powell DW, Miralda I, Ward RA, McLeish KR. Re-Examining Neutrophil Participation in GN. J Am Soc Nephrol. 2017 Aug;28(8):2275-2289. doi: 10.1681/ASN.2016121271. Epub 2017 Jun 15. Review. Erratum in: J Am Soc Nephrol. 2017 Oct;28(10 ):3129. PubMed PMID: 28620081; PubMed Central PMCID: PMC5533240.
  • McLeish KR, Merchant ML, Creed TM, Tandon S, Barati MT, Uriarte SM, Ward RA. Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis. J Leukoc Biol. 2017 Jul;102(1):19-29. doi: 10.1189/jlb.3HI0716-293RR. Epub 2017 Jan 17. PubMed PMID: 28096297; PubMed Central PMCID: PMC5470837.
  • Miralda I, Uriarte SM, McLeish KR. Multiple Phenotypic Changes Define Neutrophil Priming. Front Cell Infect Microbiol. 2017 May 29;7:217. doi: 10.3389/fcimb.2017.00217. eCollection 2017. Review. PubMed PMID: 28611952; PubMed Central PMCID: PMC5447094.