Kenneth R. McLeish, M.D., FACP

Kenneth R. McLeish, M.D., FACP

Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D., FACP

  • Professor of Medicine
  • Chief of Nephrology, Robley Rex Veterans Affairs Medical Center
VA Medical Center
800 Zorn Avenue
Louisville, KY 40206

502-852-5757 - Academic Office
502-287-4000 - VAMC

Clinical Expertise
Nephrology; Lupus Nephritis; Glomerulonephritis


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology


Education and Training

  • Medical School: Indiana University
  • Residency: Indiana University Medical Center
  • Fellowship: Indiana University Medical Center


Featured Publications

  • Korte EA, Caster DJ, Barati MT, Tan M, Zheng S, Berthier CC, Brosius FC 3rd, Vieyra MB, Sheehan RM, Kosiewicz M, Wysoczynski M, Gaffney PM, Salant DJ, McLeish KR, Powell DW. ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation. Am J Pathol. 2017 Dec;187(12):2799-2810. doi: 10.1016/j.ajpath.2017.08.018. Epub 2017 Sep 19. PubMed PMID: 28935578; PubMed Central PMCID: PMC5718094.
  • Creed TM, Tandon S, Ward RA, McLeish KR. Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils. Inflamm Res. 2017 Oct;66(10):891-899. doi: 10.1007/s00011-017-1070-2. Epub 2017 Jun 21. PubMed PMID: 28638979.
  • Caster DJ, Powell DW, Miralda I, Ward RA, McLeish KR. Re-Examining Neutrophil Participation in GN. J Am Soc Nephrol. 2017 Aug;28(8):2275-2289. doi: 10.1681/ASN.2016121271. Epub 2017 Jun 15. Review. Erratum in: J Am Soc Nephrol. 2017 Oct;28(10 ):3129. PubMed PMID: 28620081; PubMed Central PMCID: PMC5533240.
  • McLeish KR, Merchant ML, Creed TM, Tandon S, Barati MT, Uriarte SM, Ward RA. Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis. J Leukoc Biol. 2017 Jul;102(1):19-29. doi: 10.1189/jlb.3HI0716-293RR. Epub 2017 Jan 17. PubMed PMID: 28096297; PubMed Central PMCID: PMC5470837.
  • Miralda I, Uriarte SM, McLeish KR. Multiple Phenotypic Changes Define Neutrophil Priming. Front Cell Infect Microbiol. 2017 May 29;7:217. doi: 10.3389/fcimb.2017.00217. eCollection 2017. Review. PubMed PMID: 28611952; PubMed Central PMCID: PMC5447094.
  • Hobeika L, Barati MT, Caster DJ, McLeish KR, Merchant ML. Characterization of glomerular extracellular matrix by proteomic analysis of laser-captured microdissected glomeruli. Kidney Int. 2017 Feb;91(2):501-511. doi: 10.1016/j.kint.2016.09.044. Epub 2016 Dec 15. PubMed PMID: 27988214; PubMed Central PMCID: PMC5237413.
  • Ding C, Chen X, Dascani P, Hu X, Bolli R, Zhang HG, Mcleish KR, Yan J. STAT3 Signaling in B Cells Is Critical for Germinal Center Maintenance and Contributes to the Pathogenesis of Murine Models of Lupus. J Immunol. 2016 Jun 1;196(11):4477-86. doi: 10.4049/jimmunol.1502043. Epub 2016 Apr 25. PubMed PMID: 27183592; PubMed Central PMCID: PMC4875824.
  • Caster DJ, Hobeika L, Klein JB, Powell DW, McLeish KR. Changing the concepts of immune-mediated glomerular diseases through proteomics. Proteomics Clin Appl. 2015 Dec;9(11-12):967-71. doi: 10.1002/prca.201400159. Epub 2015 Jun 17. Review. PubMed PMID: 25907758; PubMed Central PMCID: PMC4618780.
  • Caster DJ, Korte EA, Merchant ML, Klein JB, Wilkey DW, Rovin BH, Birmingham DJ, Harley JB, Cobb BL, Namjou B, McLeish KR, Powell DW. Autoantibodies targeting glomerular annexin A2 identify patients with proliferative lupus nephritis. Proteomics Clin Appl. 2015 Dec;9(11-12):1012-20. doi: 10.1002/prca.201400175. Epub 2015 Jun 12. PubMed PMID: 25824007; PubMed Central PMCID: PMC4690797.
  • Lőrincz ÁM, Schütte M, Timár CI, Veres DS, Kittel Á, McLeish KR, Merchant ML, Ligeti E. Functionally and morphologically distinct populations of extracellular vesicles produced by human neutrophilic granulocytes. J Leukoc Biol. 2015 Oct;98(4):583-9. doi: 10.1189/jlb.3VMA1014-514R. Epub 2015 May 18. PubMed PMID: 25986013.