Kenneth R. McLeish, M.D., FACP

Kenneth R. McLeish, M.D., FACP

Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D., FACP

  • Professor of Medicine
  • Chief of Nephrology, Robley Rex Veterans Affairs Medical Center
VA Medical Center
800 Zorn Avenue
Louisville, KY 40206

502-852-5757 - Academic Office
502-287-4000 - VAMC


Clinical Expertise
Nephrology; Lupus Nephritis; Glomerulonephritis

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

 

Education and Training

  • Medical School: Indiana University
  • Residency: Indiana University Medical Center
  • Fellowship: Indiana University Medical Center

 

Featured Publications

  • Hobeika L, Barati MT, Caster DJ, McLeish KR, Merchant ML. Characterization of glomerular extracellular matrix by proteomic analysis of laser-captured microdissected glomeruli. Kidney Int. 2017 Feb;91(2):501-511. doi: 10.1016/j.kint.2016.09.044. Epub 2016 Dec 15. PubMed PMID: 27988214; PubMed Central PMCID: PMC5237413.
  • McLeish KR, Merchant ML, Creed TM, Tandon S, Barati MT, Uriarte SM, Ward RA. Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis. J Leukoc Biol. 2017 Jan 17. pii: jlb.3HI0716-293RR. doi: 10.1189/jlb.3HI0716-293RR. [Epub ahead of print] PubMed PMID: 28096297.
  • Ding C, Chen X, Dascani P, Hu X, Bolli R, Zhang HG, Mcleish KR, Yan J. STAT3 Signaling in B Cells Is Critical for Germinal Center Maintenance and Contributes to the Pathogenesis of Murine Models of Lupus. J Immunol. 2016 Jun 1;196(11):4477-86. doi: 10.4049/jimmunol.1502043. Epub 2016 Apr 25. PubMed PMID: 27183592; PubMed Central PMCID: PMC4875824.
  • Caster DJ, Hobeika L, Klein JB, Powell DW, McLeish KR. Changing the concepts of immune-mediated glomerular diseases through proteomics. Proteomics Clin Appl. 2015 Dec;9(11-12):967-71. doi: 10.1002/prca.201400159. Epub 2015 Jun 17. Review. PubMed PMID: 25907758; PubMed Central PMCID: PMC4618780.
  • Caster DJ, Korte EA, Merchant ML, Klein JB, Wilkey DW, Rovin BH, Birmingham DJ, Harley JB, Cobb BL, Namjou B, McLeish KR, Powell DW. Autoantibodies targeting glomerular annexin A2 identify patients with proliferative lupus nephritis. Proteomics Clin Appl. 2015 Dec;9(11-12):1012-20. doi: 10.1002/prca.201400175. Epub 2015 Jun 12. PubMed PMID: 25824007; PubMed Central PMCID: PMC4690797.
  • Lőrincz ÁM, Schütte M, Timár CI, Veres DS, Kittel Á, McLeish KR, Merchant ML, Ligeti E. Functionally and morphologically distinct populations of extracellular vesicles produced by human neutrophilic granulocytes. J Leukoc Biol. 2015 Oct;98(4):583-9. doi: 10.1189/jlb.3VMA1014-514R. Epub 2015 May 18. PubMed PMID: 25986013.
  • Jin S, Merchant ML, Ritzenthaler JD, McLeish KR, Lederer ED, Torres-Gonzalez E, Fraig M, Barati MT, Lentsch AB, Roman J, Klein JB, Rane MJ. Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators. PLoS One. 2015 Apr 7;10(4):e0121637. doi: 10.1371/journal.pone.0121637. eCollection 2015. PubMed PMID: 25848767; PubMed Central PMCID: PMC4388838.
  • Bai J, Tang L, Lomas-Neira J, Chen Y, McLeish KR, Uriarte SM, Chung CS, Ayala A. TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury. Innate Immun. 2015 Jan;21(1):42-54. doi: 10.1177/1753425913516524. Epub 2014 Jan 3. PubMed PMID: 24391146; PubMed Central PMCID: PMC4092048.
  • Arnett E, Vadia S, Nackerman CC, Oghumu S, Satoskar AR, McLeish KR, Uriarte SM, Seveau S. The pore-forming toxin listeriolysin O is degraded by neutrophil metalloproteinase-8 and fails to mediate Listeria monocytogenes intracellular survival in neutrophils. J Immunol. 2014 Jan 1;192(1):234-44. doi: 10.4049/jimmunol.1301302. Epub 2013 Dec 6. PubMed PMID: 24319266; PubMed Central PMCID: PMC3876913.
  • Caster DJ, Korte EA, Nanda SK, McLeish KR, Oliver RK, G'sell RT, Sheehan RM, Freeman DW, Coventry SC, Kelly JA, Guthridge JM, James JA, Sivils KL, Alarcon-Riquelme ME, Scofield RH, Adrianto I, Gaffney PM, Stevens AM, Freedman BI, Langefeld CD, Tsao BP, Pons-Estel BA, Jacob CO, Kamen DL, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Kimberly RP, Martin J, Merrill JT, Harley JB, Kaufman KM, Reveille JD, Anaya JM, Criswell LA, Vila LM, Petri M, Ramsey-Goldman R, Bae SC, Boackle SA, Vyse TJ, Niewold TB, Cohen P, Powell DW. ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol. 2013 Nov;24(11):1743-54. doi: 10.1681/ASN.2013020148. Epub 2013 Aug 22. PubMed PMID: 23970121; PubMed Central PMCID: PMC3810087.