Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D.

  • Professor of Medicine
  • Chief of Nephrology, Robley Rex Veterans Affairs Medical Center
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-813-6699 - Patient Appointments


Clinical Expertise
Nephrology; Lupus Nephritis; Glomerulonephritis

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

 

Education and Training

  • Medical School: Indiana University
  • Residency: Indiana University Medical Center
  • Fellowship: Indiana University Medical Center

 

Recent Publications

  • Bai J, Tang L, Loma-Neira J, Chen Y, McLeish KR, Uriarte SM, Chung CS, Ayala A. TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury. Innate Immun. 2014 Jan 3. [Epub ahead of print] PubMed PMID: 24391146.
  • Arnett E, Vadia S, Nackerman CC, Oghumu S, Satoskar AR, McLeish KR, Uriarte SM, Seveau S. The pore-forming toxin listeriolysin O is degraded by neutrophil metalloproteinase-8 and fails to mediate Listeria monocytogenes intracellular survival in neutrophils. J Immunol. 2014 Jan 1;192(1):234-44. doi: 10.4049/jimmunol.1301302. Epub 2013 Dec 6. PubMed PMID: 24319266; PubMed Central PMCID: PMC3876913.
  • Caster DJ, Korte EA, Nanda SK, McLeish KR, Oliver RK, G'sell RT, Sheehan RM, Freeman DW, Coventry SC, Kelly JA, Guthridge JM, James JA, Sivils KL, Alarcon-Riquelme ME, Scofield RH, Adrianto I, Gaffney PM, Stevens AM, Freedman BI, Langefeld CD, Tsao BP, Pons-Estel BA, Jacob CO, Kamen DL, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Kimberly RP, Martin J, Merrill JT, Harley JB, Kaufman KM, Reveille JD, Anaya JM, Criswell LA, Vila LM, Petri M, Ramsey-Goldman R, Bae SC, Boackle SA, Vyse TJ, Niewold TB, Cohen P, Powell DW. ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol. 2013 Nov;24(11):1743-54. doi: 10.1681/ASN.2013020148. Epub 2013 Aug 22. PubMed PMID: 23970121; PubMed Central PMCID: PMC3810087.
  • McLeish KR, Merchant ML, Klein JB, Ward RA. Technical note: proteomic approaches to fundamental questions about neutrophil biology. J Leukoc Biol. 2013 Oct;94(4):683-92. doi: 10.1189/jlb.1112591. Epub 2013 Mar 7. Review. PubMed PMID: 23470899.
  • Schissler MM, Zaidi S, Kumar H, Deo D, Brier ME, McLeish KR. Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury. Nephrology (Carlton). 2013 Mar;18(3):183-7. doi: 10.1111/nep.12036. PubMed PMID: 23336108.
  • Uriarte SM, Rane MJ, Merchant ML, Jin S, Lentsch AB, Ward RA, McLeish KR. Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats. Shock. 2013 Mar;39(3):286-92. doi: 10.1097/SHK.0b013e318282c9a1. PubMed PMID: 23364427; PubMed Central PMCID: PMC3578018.
  • Timár CI, Lorincz AM, Csépányi-Kömi R, Vályi-Nagy A, Nagy G, Buzás EI, Iványi  Z, Kittel A, Powell DW, McLeish KR, Ligeti E. Antibacterial effect of microvesicles released from human neutrophilic granulocytes. Blood. 2013 Jan 17;121(3):510-8. doi: 10.1182/blood-2012-05-431114. Epub 2012 Nov 8. PubMed PMID: 23144171; PubMed Central PMCID: PMC3548170.
  • McLeish KR, Uriarte SM, Tandon S, Creed TM, Le J, Ward RA. Exocytosis of neutrophil granule subsets and activation of prolyl isomerase 1 are required for respiratory burst priming. J Innate Immun. 2013;5(3):277-89. doi: 10.1159/000345992. Epub 2013 Jan 26. PubMed PMID: 23363774; PubMed Central PMCID: PMC3691856.
  • Liu W, Yan M, Liu Y, McLeish KR, Coleman WG Jr, Rodgers GP. Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice. J Immunol. 2012 Sep 1;189(5):2460-7. doi: 10.4049/jimmunol.1103179. Epub 2012 Jul 27. PubMed PMID: 22844115; PubMed Central PMCID: PMC3424379.
  • Gomez-Cambronero J, Allen LA, Cathcart MK, Justement LB, Kovacs EJ, McLeish KR, Nauseef WM. Writing a first grant proposal. Nat Immunol. 2012 Jan 19;13(2):105-8. doi: 10.1038/ni.2183. PubMed PMID: 22261956.