Eleanor D. Lederer, M.D., FACP, FASN

Eleanor D. Lederer, M.D., FACP, FASN

Eleanor D. Lederer, M.D., FASN

Eleanor D. Lederer, M.D., FACP, FASN

  • Professor of Medicine
  • Interim Chair, Department of Medicine
  • Chief, Division of Nephrology & Hypertension
  • Director, Nephrology Fellowship Training Program
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-588-4710 - Patient Appointments

Clinical Expertise
Nephrology; Transplant; Kidney Stones; Genetic Kidney Disease; High Risk Pregnancy


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology


Education and Training

  • Medical School: Baylor University College of Medicine
  • Residency: Baylor University Affiliated Hospitals
  • Fellowship: Baylor University College of Medicine


    Featured Publications

    • Lederer E. Why would serum phosphorus correlate with cardiovascular risk, and how is the clinician supposed to use this information? Clin Nephrol. 2017 Jan;87 (2017)(1):1-10. Review. PubMed PMID: 27841147.
    • Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ. Low dose ouabain stimulates NaK ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells. Biochim Biophys Acta. 2016 Nov;1863(11):2624-2636. doi: 10.1016/j.bbamcr.2016.07.008. Epub 2016 Aug 3. PubMed PMID: 27496272; PubMed Central PMCID: PMC5206903.
    • Khundmiri SJ, Murray RD, Lederer E. PTH and Vitamin D. Compr Physiol. 2016 Mar 15;6(2):561-601. doi: 10.1002/cphy.c140071. Review. PubMed PMID: 27065162.
    • Murray RD, Merchant ML, Hardin E, Clark B, Khundmiri SJ, Lederer ED. Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA. Am J Physiol Cell Physiol. 2016 Feb 1;310(3):C205-15. doi: 10.1152/ajpcell.00192.2015. Epub 2015 Nov 25. PubMed PMID: 26834145.
    • Clark BJ, Murray RD, Salyer SA, Tyagi SC, Arumugam C, Khundmiri SJ, Lederer ED. Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1. Cell Physiol Biochem. 2016;39(1):1-12. doi: 10.1159/000445601. Epub 2016 Jun 20. PubMed PMID: 27322746.
    • Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED. Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter. Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F109-19. PubMed PMID: 25995109; PubMed Central PMCID: PMC4504931.
    • Jin S, Merchant ML, Ritzenthaler JD, McLeish KR, Lederer ED, Torres-Gonzalez E, Fraig M, Barati MT, Lentsch AB, Roman J, Klein JB, Rane MJ. Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators. PLoS One. 2015 Apr 7;10(4):e0121637. doi: 10.1371/journal.pone.0121637. eCollection 2015. PubMed PMID: 25848767; PubMed Central PMCID: PMC4388838.
    • Lederer E. Regulation of serum phosphate. J Physiol. 2014 Sep 15;592(18):3985-95. doi: 10.1113/jphysiol.2014.273979. Epub 2014 Jun 27. Review. PubMed PMID: 24973411; PubMed Central PMCID: PMC4198009.
    • Lederer E. Renal phosphate transporters. Curr Opin Nephrol Hypertens. 2014 Sep;23(5):502-6. doi: 10.1097/MNH.0000000000000053. Review. PubMed PMID: 25028980; PubMed Central PMCID: PMC4361807.
    • Khundmiri SJ, Salyer SA, Farmer B, Qipshidze-Kelm N, Murray RD, Clark BJ, Xie Z, Pressley TA, Lederer ED. Structural determinants for the ouabain-stimulated increase in Na-K ATPase activity. Biochim Biophys Acta. 2014 Jun;1843(6):1089-102. doi: 10.1016/j.bbamcr.2014.02.005. Epub 2014 Feb 22. PubMed PMID: 24566089.