Eleanor D. Lederer, M.D., FASN, FACP

Eleanor D. Lederer, M.D., FASN, FACP

Eleanor D. Lederer, M.D., FASN

Eleanor D. Lederer, M.D., FASN, FACP

  • Professor of Medicine
  • Chief, Division of Nephrology & Hypertension
  • Director, Nephrology Training Program
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757 - Academic Office
502-813-6699 - Patient Appointments


Clinical Expertise
Nephrology; Transplant; Kidney Stones; Genetic Kidney Disease; High Risk Pregnancy

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

 

Education and Training

  • Medical School: Baylor University College of Medicine
  • Residency: Baylor University Affiliated Hospitals
  • Fellowship: Baylor University College of Medicine

 

    Recent Publications

    • Khundmiri SJ, Salyer SA, Farmer B, Qipshidze-Kelm N, Murray RD, Clark BJ, Xie Z, Pressley TA, Lederer ED. Structural determinants for the ouabain-stimulated increase in Na-K ATPase activity. Biochim Biophys Acta. 2014 Feb 22;1843(6):1089-1102. doi: 10.1016/j.bbamcr.2014.02.005. [Epub ahead of print] PubMed PMID: 24566089.
    • Pushpakumar S, Kundu S, Pryor T, Givvimani S, Lederer E, Tyagi SC, Sen U. Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice. J Hypertens. 2013 Nov;31(11):2270-81; discussion 2281. doi: 10.1097/HJH.0b013e3283649b33. PubMed PMID: 24077247.
    • Salyer SA, Parks J, Barati MT, Lederer ED, Clark BJ, Klein JD, Khundmiri SJ. Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor. Biochim Biophys Acta. 2013 Oct;1833(10):2143-52. doi: 10.1016/j.bbamcr.2013.05.009. Epub 2013 May 16. PubMed PMID: 23684706.
    • Salyer SA, Olberding JR, Distler AA, Lederer ED, Clark BJ, Delamere NA, Khundmiri SJ. Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells. Biochim Biophys Acta. 2013 Oct;1832(10):1734-43. doi: 10.1016/j.bbadis.2013.04.023. Epub 2013 Apr 29. PubMed PMID: 23639630.
    • Murray RD, Holthouser K, Clark BJ, Salyer SA, Barati MT, Khundmiri SJ, Lederer ED. Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability. Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1076-85. doi: 10.1152/ajprenal.00632.2012. Epub 2013 Jan 23. PubMed PMID: 23344572.
    • Lederer ED, Klein JB. New treatments for CKD--new insights into pathogenesis. J Am Soc Nephrol. 2012 Oct;23(10):1601-3. Epub 2012 Sep 13. PubMed PMID: 22975668; PubMed Central PMCID: PMC3458472.
    • Weinman EJ, Lederer ED. NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones. Am J Physiol Renal Physiol. 2012 Aug 1;303(3):F321-7. doi: 10.1152/ajprenal.00093.2012. Epub 2012 Apr 25. PubMed PMID: 22535796; PubMed Central PMCID: PMC3433861.
    • Lederer E, Miyamoto K. Clinical consequences of mutations in sodium phosphate cotransporters. Clin J Am Soc Nephrol. 2012 Jul;7(7):1179-87. doi: 10.2215/CJN.09090911. Epub 2012 Apr 19. Review. PubMed PMID: 22516291.
    • Weinman EJ, Lederer ED. PTH-mediated inhibition of the renal transport of phosphate. Exp Cell Res. 2012 May 15;318(9):1027-32. doi: 10.1016/j.yexcr.2012.02.037. Epub 2012 Mar 5. Review. PubMed PMID: 22417892; PubMed Central PMCID: PMC3334409.
    • Lederer E, Levi M. The flux of phosphate: rapid evolution. Adv Chronic Kidney Dis. 2011 Mar;18(2):61-2. doi: 10.1053/j.ackd.2011.02.001. PubMed PMID: 21406289.