Maxwell M. Krem, M.D., Ph.D.

Maxwell M. Krem, M.D., Ph.D.

Maxwell Krem

Maxwell M. Krem, M.D., Ph.D.

  • Assistant Professor of Medicine

James Graham Brown Cancer Center
529 South Jackson Street
Louisville, KY 40202
502-562-4363 - Academic Office
502-562-4363 - Patient Appointments


Clinical Expertise
Blood and Bone Marrow Transplantation

 

Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Medical Oncology

Education and Training

  • Medical School: Washington University School of Medicine
  • Residency: Washington University Affiliated Hospitals
  • Fellowship: University of Washington/Fred Hutchinson Cancer Research Center

 

Featured Publications

  • Krem MM, Yan J. To b(ortezomib) or not to be: the stroma's the thing. J Pathol. 2016 Oct;240(2):123-5. doi: 10.1002/path.4763. Epub 2016 Sep 9. PubMed PMID: 27340009; PubMed Central PMCID: PMC5037003.
  • Park J, Kim S, Joh J, Remick SC, Miller DM, Yan J, Kanaan Z, Chao JH, Krem MM, Basu SK, Hagiwara S, Kenner L, Moriggl R, Bunting KD, Tse W. MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling. Oncotarget. 2016 Jul 12;7(28):43960-43973. doi: 10.18632/oncotarget.9759. PubMed PMID: 27259262; PubMed Central PMCID: PMC5190071.
  • Claudino WM, Gibson B, Tse W, Krem M, Grewal J. Methotrexate-associated primary cutaneous CD30-positive cutaneous T-cell lymphoproliferative disorder: a case illustration and a brief review. Am J Blood Res. 2016 May 18;6(1):1-5. eCollection 2016. PubMed PMID: 27335685; PubMed Central PMCID: PMC4913234.
  • Krem MM, Press OW, Horwitz MS, Tidwell T. Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy. Br J Haematol. 2015 Oct;171(1):13-28. doi: 10.1111/bjh.13507. Epub 2015 May 26. Review. PubMed PMID: 26018193.
  • Krem MM, Gopal AK. New targeted therapies for indolent B-cell malignancies in older patients. Am Soc Clin Oncol Educ Book. 2015:e365-74. doi: 10.14694/EdBook_AM.2015.35.e365. Review. PubMed PMID: 25993198.
  • Krem MM, Horwitz MS. Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma pathogenesis. Commun Integr Biol. 2013 May 1;6(3):e23544. doi: 10.4161/cib.23544. Epub 2013 May 13. PubMed PMID: 23713010; PubMed Central PMCID: PMC3656006.
  • Krem MM, Luo P, Ing BI, Horwitz MS. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. J Biol Chem. 2012 Nov 9;287(46):39083-93. doi: 10.1074/jbc.M112.390088. Epub 2012 Sep 17. PubMed PMID: 22988245; PubMed Central PMCID: PMC3493949.
  • Krem MM, Salipante SJ, Horwitz MS. Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma. Cell Cycle. 2010 Feb 15;9(4):670-5. Epub 2010 Mar 2. PubMed PMID: 20107318; PubMed Central PMCID: PMC4523393.
  • Salipante SJ, Mealiffe ME, Wechsler J, Krem MM, Liu Y, Namkoong S, Bhagat G, Kirchhoff T, Offit K, Lynch H, Wiernik PH, Roshal M, McMaster ML, Tucker M, Fromm JR, Goldin LR, Horwitz MS. Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14920-5. doi: 10.1073/pnas.0904231106. Epub 2009 Aug 12. PubMed PMID: 19706467; PubMed Central PMCID: PMC2736436.
  • Liu F, Kunter G, Krem MM, Eades WC, Cain JA, Tomasson MH, Hennighausen L, Link DC. Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest. 2008 Mar;118(3):946-55. doi: 10.1172/JCI32704. PubMed PMID: 18292815; PubMed Central PMCID: PMC2248325.