Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

  • Associate Professor of Medicine
  • Director, Cardiovascular Disease Prevention
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-7959 - Academic Office
502-588-4600 - Patient Appointments

Clinical Expertise
Coronary Artery Disease; Coronary Atherothrombosis; Lipidology; Cardiac Intensive Care

Research Interests
Biomarker development for acute myocardial infarction (atherothrombotic and non-atherothrmbotic); Cardiovascular risk prediction; Plaque disruption and coronary thrombosis; Omics


Board Certifications

  • American Board of Internal Medicine -
    Cardiovascular Disease

Education and Training

  • Medical School: Georgetown University
  • Residency: Emory University Hospital
  • Fellowship: The Johns Hopkins University
  • M.Sc.: Emory University


Featured Publications

  • DeFilippis AP, Trainor PJ, Hill BG, Amraotkar AR, Rai SN, Hirsch GA, Rouchka EC, Bhatnagar A. Identification of a plasma metabolomic signature of thrombotic myocardial infarction that is distinct from non-thrombotic myocardial infarction and stable coronary artery disease. PLoS One. 2017 Apr 17;12(4):e0175591. doi: 10.1371/journal.pone.0175591. eCollection 2017. PubMed PMID: 28414761.
  • Trainor PJ, Hill BG, Carlisle SM, Rouchka EC, Rai SN, Bhatnagar A, DeFilippis AP. Systems characterization of differential plasma metabolome perturbations following thrombotic and non-thrombotic myocardial infarction. J Proteomics. 2017 Mar 22. pii: S1874-3919(17)30098-2. doi: 10.1016/j.jprot.2017.03.014. [Epub ahead of print] PubMed PMID: 28341595.
  • DeFilippis AP, Young R, McEvoy JW, Michos ED, Sandfort V, Kronmal RA, McClelland RL, Blaha MJ. Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern multi-ethnic cohort. Eur Heart J. 2017 Feb 21;38(8):598-608. doi: 10.1093/eurheartj/ehw301. PubMed PMID: 27436865.
  • Shah JS, Rai SN, DeFilippis AP, Hill BG, Bhatnagar A, Brock GN. Distribution based nearest neighbor imputation for truncated high dimensional data with applications to pre-clinical and clinical metabolomics studies. BMC Bioinformatics. 2017 Feb 20;18(1):114. doi: 10.1186/s12859-017-1547-6. PubMed PMID: 28219348; PubMed Central PMCID: PMC5319174.
  • Loughran J, Puthawala T, Sutton BS, Brown LE, Pronovost PJ, DeFilippis AP. The Cardiovascular Intensive Care Unit-An Evolving Model for Health Care Delivery. J Intensive Care Med. 2017 Feb;32(2):116-123. doi: 10.1177/0885066615624664. Epub 2016 Jul 8. PubMed PMID: 26768424.
  • Amraotkar AR, Ghafghazi S, Trainor PJ, Hargis CW, Irfan AB, Rai SN, Bhatnagar A, DeFilippis AP. Presence of multiple coronary angiographic characteristics for the diagnosis of acute coronary thrombus. Cardiol J. 2017;24(1):25-34. doi: 10.5603/CJ.a2017.0004. Epub 2017 Feb 2. PubMed PMID: 28150291.
  • DeFilippis AP, Chernyavskiy I, Amraotkar AR, Trainor PJ, Kothari S, Ismail I, Hargis CW, Korley FK, Leibundgut G, Tsimikas S, Rai SN, Bhatnagar A. Circulating levels of plasminogen and oxidized phospholipids bound to plasminogen distinguish between atherothrombotic and non-atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2016 Jul;42(1):61-76. doi: 10.1007/s11239-015-1292-5. PubMed PMID: 26510751.
  • Keith RJ, Al Rifai M, Carruba C, De Jarnett N, McEvoy JW, Bhatnagar A, Blaha MJ, Defilippis AP. Tobacco Use, Insulin Resistance, and Risk of Type 2 Diabetes: Results from the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2016 Jun 20;11(6):e0157592. doi: 10.1371/journal.pone.0157592. eCollection 2016. PubMed PMID: 27322410; PubMed Central PMCID: PMC4913922.
  • Feldman DI, Cainzos-Achirica M, Billups KL, DeFilippis AP, Chitaley K, Greenland P, Stein JH, Budoff MJ, Dardari Z, Miner M, Blumenthal RS, Nasir K, Blaha MJ. Subclinical Vascular Disease and Subsequent Erectile Dysfunction: The Multiethnic Study of Atherosclerosis (MESA). Clin Cardiol. 2016 May;39(5):291-8. doi: 10.1002/clc.22530. Epub 2016 May 3. PubMed PMID: 27145089; PubMed Central PMCID: PMC4879072.
  • Amraotkar AR, Pachika A, Grubb KJ, DeFilippis AP. Rapid Extracorporeal Membrane Oxygenation Overcomes Fulminant Myocarditis Induced by 5‑Fluorouracil. Tex Heart Inst J. 2016 Apr 1;43(2):178-82. doi: 10.14503/THIJ-15-5100. eCollection 2016 Apr. PubMed PMID: 27127440; PubMed Central PMCID: PMC4845572.