Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

  • Associate Professor of Medicine
  • Director, Cardiovascular Disease Prevention
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-7959 - Academic Office
502-588-4600 - Patient Appointments

Clinical Expertise
Coronary Artery Disease; Coronary Atherothrombosis; Lipidology; Cardiac Intensive Care

Research Interests
Biomarker development for acute myocardial infarction (atherothrombotic and non-atherothrmbotic); Cardiovascular risk prediction; Plaque disruption and coronary thrombosis; Omics


Board Certifications

  • American Board of Internal Medicine -
    Cardiovascular Disease

Education and Training

  • Medical School: Georgetown University
  • Residency: Emory University Hospital
  • Fellowship: The Johns Hopkins University
  • M.Sc.: Emory University


Featured Publications

  • Keith RJ, Fetterman JL, Riggs DW, O'Toole T, Nystoriak JL, Holbrook M, Lorkiewicz P, Bhatnagar A, DeFilippis AP, Hamburg NM. Protocol to assess the impact of tobacco-induced volatile organic compounds on cardiovascular risk in a cross- sectional cohort: Cardiovascular Injury due to Tobacco Use study. BMJ Open. 2018 Mar 30;8(3):e019850. doi: 10.1136/bmjopen-2017-019850. PubMed PMID: 29602846; PubMed Central PMCID: PMC5884372.
  • Trainor PJ, Yampolskiy RV, DeFilippis AP. Wisdom of artificial crowds feature selection in untargeted metabolomics: An application to the development of a blood-based diagnostic test for thrombotic myocardial infarction. J Biomed Inform. 2018 Mar 22. pii: S1532-0464(18)30049-2. doi: 10.1016/j.jbi.2018.03.007. [Epub ahead of print] PubMed PMID: 29578100.
  • Tibuakuu M, Kianoush S, DeFilippis AP, McEvoy JW, Zhao D, Guallar E, Ballantyne CM, Hoogeveen RC, Blaha MJ, Michos ED. Usefulness of Lipoprotein-Associated Phospholipase A(2) Activity and C-Reactive Protein in Identifying High-Risk Smokers for Atherosclerotic Cardiovascular Disease (from the Atherosclerosis Risk in Communities Study). Am J Cardiol. 2018 Feb 6. pii: S0002-9149(18)30162-0. doi: 10.1016/j.amjcard.2018.01.020. [Epub ahead of print] PubMed PMID: 29525060.
  • White WB, Cain LR, Benjamin EJ, DeFilippis AP, Blaha MJ, Wang W, Okhomina V, Keith RJ, Al Rifai M, Kianoush S, Winniford MD, Robertson RM, Bhatnagar A, Correa A, Hall ME. High-Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2018 Jan 12;7(2). pii: e007413. doi: 10.1161/JAHA.117.007413. PubMed PMID: 29330255; PubMed Central PMCID: PMC5850161.
  • Kianoush S, Al Rifai M, Cainzos-Achirica M, Al-Mallah MH, Tison GH, Yeboah J, Miedema MD, Allison MA, Wong ND, DeFilippis AP, Longstreth W, Nasir K, Budoff MJ, Matsushita K, Blaha MJ. Thoracic extra-coronary calcification for the prediction of stroke: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2017 Dec;267:61-67. doi: 10.1016/j.atherosclerosis.2017.10.010. Epub 2017 Oct 7. PubMed PMID: 29100062; PubMed Central PMCID: PMC5705470.
  • Amraotkar AR, Song DD, Otero D, Trainor PJ, Ismail I, Kothari V, Singh A, Moore JB 4th, Rai SN, DeFilippis AP. Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction. Clin Appl Thromb Hemost. 2017 Nov;23(8):1052-1059. doi: 10.1177/1076029616683804. Epub 2016 Dec 21. PubMed PMID: 28294633; PubMed Central PMCID: PMC5572529.
  • Keith RJ, Riggs DW, Conklin DJ, Lorkiewicz P, Srivastava S, Bhatnagar A, DeFilippis AP. Nicotine Metabolism in Adults with Type 2 Diabetes. Nicotine Tob Res. 2017 Sep 27. doi: 10.1093/ntr/ntx214. [Epub ahead of print] PubMed PMID: 29059414.
  • Tibuakuu M, Kamimura D, Kianoush S, DeFilippis AP, Al Rifai M, Reynolds LM, White WB, Butler KR, Mosley TH, Turner ST, Kullo IJ, Hall ME, Blaha MJ. The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study. PLoS One. 2017 Sep 18;12(9):e0184914. doi: 10.1371/journal.pone.0184914. eCollection 2017. PubMed PMID: 28922371; PubMed Central PMCID: PMC5602636.
  • Kianoush S, Bittencourt MS, Lotufo PA, Bensenor IM, Jones SR, DeFilippis AP, Toth PP, Otvos JD, Tibuakuu M, Hall ME, Harada PHN, Blaha MJ. Association Between Smoking and Serum GlycA and High-Sensitivity C-Reactive Protein Levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of  Adult Health (ELSA-Brasil). J Am Heart Assoc. 2017 Aug 23;6(8). pii: e006545. doi: 10.1161/JAHA.117.006545. Erratum in: J Am Heart Assoc. 2017 Dec 2;6(12 ):. PubMed PMID: 28838917; PubMed Central PMCID: PMC5586473.
  • Sultan A, Zheng Y, Trainor PJ, Siow Y, Amraotkar AR, Hill BG, DeFilippis AP. Circulating Prolidase Activity in Patients with Myocardial Infarction. Front Cardiovasc Med. 2017 Jul 31;4:50. doi: 10.3389/fcvm.2017.00050. eCollection 2017. PubMed PMID: 28824924; PubMed Central PMCID: PMC5535509.