Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

  • Associate Professor of Medicine
  • Assistant Professor of Physiology
  • Director, Cardiac Intensive Care
  • Director, Cardiovascular Disease Prevention
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-7959 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Coronary Artery Disease; Coronary Atherothrombosis; Lipidology; Cardiac Intensive Care

Research Interests
Biomarker development for acute myocardial infarction (atherothrombotic and non-atherothrmbotic); Cardiovascular risk prediction; Plaque disruption and coronary thrombosis; Omics


Board Certifications

  • American Board of Internal Medicine -
    Cardiovascular Disease

Education and Training

  • Medical School: Georgetown University
  • Residency: Emory University Hospital
  • Fellowship: The Johns Hopkins University
  • M.Sc.: Emory University

Featured Publications

  • Berg DD, Bohula EA, van Diepen S, Katz JN, Alviar CL, Baird-Zars VM, Barnett CF, Barsness GW, Burke JA, Cremer PC, Cruz J, Daniels LB, DeFilippis AP, Haleem A, Hollenberg SM, Horowitz JM, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Ng J, Orgel R, Overgaard CB, Park JG, Phreaner N, Roswell RO, Schulman SP, Jeffrey Snell R, Solomon MA, Ternus B, Tymchak W, Vikram F, Morrow DA. Epidemiology of Shock in Contemporary Cardiac Intensive Care Units. Circ Cardiovasc Qual Outcomes. 2019 Mar;12(3):e005618. doi: 10.1161/CIRCOUTCOMES.119.005618. PubMed PMID: 30879324.
  • Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Stokes A, Bhatnagar A, Nasir K, Blaha MJ. The association between e-cigarette use and cardiovascular disease among never and current combustible cigarette smokers: BRFSS 2016 & 2017. Am J Med. 2019 Mar 7. pii: S0002-9343(19)30211-6. doi: 10.1016/j.amjmed.2019.02.016. [Epub ahead of print] PubMed PMID: 30853474.
  • Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz P, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound (VOC) metabolites in Cigarette smokers, Electronic Nicotine Device Users, Dual Users and Non- users of tobacco. Nicotine Tob Res. 2019 Feb 13. doi: 10.1093/ntr/ntz021. [Epub ahead of print] PubMed PMID: 30759242.
  • Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H801-H827. doi: 10.1152/ajpheart.00591.2018. Epub 2019 Feb 1. PubMed PMID: 30707616.
  • Clark D 3rd, Cain LR, Blaha MJ, DeFilippis AP, Mentz RJ, Kamimura D, White WB, Butler KR, Robertson RM, Bhatnagar A, Butler J, Correa A, Benjamin EJ, Hall ME. Cigarette Smoking and Subclinical Peripheral Arterial Disease in Blacks of the Jackson Heart Study. J Am Heart Assoc. 2019 Feb 5;8(3):e010674. doi: 10.1161/JAHA.118.010674. PubMed PMID: 30672360; PubMed Central PMCID: PMC6405586.
  • Yeager R, Riggs DW, DeJarnett N, Tollerud DJ, Wilson J, Conklin DJ, O'Toole TE, McCracken J, Lorkiewicz P, Xie Z, Zafar N, Krishnasamy SS, Srivastava S, Finch J, Keith RJ, DeFilippis A, Rai SN, Liu G, Bhatnagar A. Association Between Residential Greenness and Cardiovascular Disease Risk. J Am Heart Assoc. 2018 Dec 18;7(24):e009117. doi: 10.1161/JAHA.118.009117. PubMed PMID: 30561265; PubMed Central PMCID: PMC6405613.
  • Kianoush S, DeFilippis AP, Rodriguez CJ, Rifai MA, Benjamin EJ, Hall ME, Ouyang P, Allison MA, Blaha MJ. Race/Ethnicity-Specific Associations between Smoking, Serum Leptin, and Abdominal Fat: The Multi-Ethnic Study of Atherosclerosis. Ethn Dis. 2018 Oct 18;28(4):531-538. doi: 10.18865/ed.28.4.531. eCollection 2018 Fall. PubMed PMID: 30405297; PubMed Central PMCID: PMC6200307.
  • Mirbolouk M, Charkhchi P, Orimoloye OA, Uddin SMI, Kianoush S, Jaber R, Bhatnagar A, Benjamin EJ, Hall ME, DeFilippis AP, Maziak W, Nasir K, Blaha MJ. E-Cigarette Use Without a History of Combustible Cigarette Smoking Among U.S. Adults: Behavioral Risk Factor Surveillance System, 2016. Ann Intern Med. 2018 Oct 9. doi: 10.7326/M18-1826. [Epub ahead of print] PubMed PMID: 30304466.
  • Mirbolouk M, Charkhchi P, Kianoush S, Uddin SMI, Orimoloye OA, Jaber R, Bhatnagar A, Benjamin EJ, Hall ME, DeFilippis AP, Maziak W, Nasir K, Blaha MJ. Prevalence and Distribution of E-Cigarette Use Among U.S. Adults: Behavioral Risk Factor Surveillance System, 2016. Ann Intern Med. 2018 Oct 2;169(7):429-438. doi: 10.7326/M17-3440. Epub 2018 Aug 28. PubMed PMID: 30167658.
  • Jaber RM, Mirbolouk M, DeFilippis AP, Maziak W, Keith R, Payne T, Stokes A, Benjamin E, Bhatnagar A, Blankstein R, Saxena A, Blaha MJ, Nasir K. Electronic Cigarette Use Prevalence, Associated Factors, and Pattern by Cigarette Smoking Status in the United States From NHANES (National Health and Nutrition Examination Survey) 2013-2014. J Am Heart Assoc. 2018 Jul 14;7(14). pii: e008178. doi: 10.1161/JAHA.117.008178. PubMed PMID: 30007934; PubMed Central PMCID: PMC6064855.