Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

Andrew P. DeFilippis, M.D., M.Sc.

  • Associate Professor of Medicine
  • Assistant Professor of Physiology
  • Interim Division Chief, Division of Cardiovascular Medicine
  • Director, Cardiac Intensive Care
  • Director, Cardiovascular Disease Prevention
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-7959 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Coronary Artery Disease; Coronary Atherothrombosis; Lipidology; Cardiac Intensive Care

Research Interests
Biomarker development for acute myocardial infarction (atherothrombotic and non-atherothrmbotic); Cardiovascular risk prediction; Plaque disruption and coronary thrombosis; Omics


Board Certifications

  • American Board of Internal Medicine -
    Cardiovascular Disease

Education and Training

  • Medical School: Georgetown University
  • Residency: Emory University Hospital
  • Fellowship: The Johns Hopkins University
  • M.Sc.: Emory University

Featured Publications

  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MHEM, Zafar N, Krishnasamy S, DeFilippis A, Turner J, Rai SN, Bhatnagar A. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ. 2020 Mar 10;707:135435. doi: 10.1016/j.scitotenv.2019.135435. Epub 2019 Nov 23. PubMed PMID: 31865083.
  • Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Bhatnagar A, Biswal SS, Blaha MJ. Association Between E-Cigarette Use and Chronic Obstructive Pulmonary Disease by Smoking Status: Behavioral Risk Factor Surveillance System 2016 and 2017. Am J Prev Med. 2020 Mar;58(3):336-342. doi: 10.1016/j.amepre.2019.10.014. Epub 2020 Jan 2. PubMed PMID: 31902685.
  • Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz PK, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco. Nicotine Tob Res. 2020 Feb 6;22(2):264-272. doi: 10.1093/ntr/ntz021. PubMed PMID: 30759242.
  • Owolabi US, Amraotkar AR, Coulter AR, Singam NSV, Aladili BN, Singh A, Trainor PJ, Mitra R, DeFilippis AP. Change in matrix metalloproteinase 2, 3, and 9 levels at the time of and after acute atherothrombotic myocardial infarction. J Thromb Thrombolysis. 2020 Feb;49(2):235-244. doi: 10.1007/s11239-019-02004-7. PubMed PMID: 31808123.
  • van Diepen S, Tymchak W, Bohula EA, Park JG, Daniels LB, Phreaner N, Barnett CF, Kenigsberg BB, DeFilippis A, Singam NS, Barsness GW, Jentzer JC, Ternus B, Morrow DA, Katz JN; Critical Care Cardiology Trials Network Investigators. Incidence, underlying conditions, and outcomes of patients receiving acute renal replacement therapies in tertiary cardiac intensive care units: An analysis from the Critical Care Cardiology Trials Network Registry. Am Heart J. 2020 Jan 15;222:8-14. doi: 10.1016/j.ahj.2020.01.005. [Epub ahead of print] PubMed PMID: 32006910.
  • Obisesan OH, Mirbolouk M, Osei AD, Orimoloye OA, Uddin SMI, Dzaye O, El Shahawy O, Al Rifai M, Bhatnagar A, Stokes A, Benjamin EJ, DeFilippis AP, Blaha MJ. Association Between e-Cigarette Use and Depression in the Behavioral Risk Factor Surveillance System, 2016-2017. JAMA Netw Open. 2019 Dec 2;2(12):e1916800. doi: 10.1001/jamanetworkopen.2019.16800. PubMed PMID: 31800073; PubMed Central PMCID: PMC6902792.
  • DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA. Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury. Circulation. 2019 Nov 12;140(20):1661-1678. doi: 10.1161/CIRCULATIONAHA.119.040631. Epub 2019 Aug 16. PubMed PMID: 31416350; PubMed Central PMCID: PMC6855329.
  • Berg DD, Barnett CF, Kenigsberg BB, Papolos A, Alviar CL, Baird-Zars VM, Barsness GW, Bohula EA, Brennan J, Burke JA, Carnicelli AP, Chaudhry SP, Cremer PC, Daniels LB, DeFilippis AP, Gerber DA, Granger CB, Hollenberg S, Horowitz JM, Gladden JD, Katz JN, Keeley EC, Keller N, Kontos MC, Lawler PR, Menon V, Metkus TS, Miller PE, Nativi-Nicolau J, Newby LK, Park JG, Phreaner N, Roswell RO, Schulman SP, Sinha SS, Snell RJ, Solomon MA, Teuteberg JJ, Tymchak W, van Diepen S, Morrow DA. Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry. Circ Heart Fail. 2019 Nov;12(11):e006635. doi: 10.1161/CIRCHEARTFAILURE.119.006635. Epub 2019 Nov 11. PubMed PMID: 31707801; PubMed Central PMCID: PMC7008928.
  • Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Dardari ZA, DeFilippis AP, Bhatnagar A, Blaha MJ. The association between e-cigarette use and asthma among never combustible cigarette smokers: behavioral risk factor surveillance system (BRFSS) 2016 & 2017. BMC Pulm Med. 2019 Oct 16;19(1):180. doi: 10.1186/s12890-019-0950-3. PubMed PMID: 31619218; PubMed Central PMCID: PMC6796489.
  • Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Stokes A, Bhatnagar A, Nasir K, Blaha MJ. Association Between E-Cigarette Use and Cardiovascular Disease Among Never and Current Combustible-Cigarette Smokers. Am J Med. 2019 Aug;132(8):949-954.e2. doi: 10.1016/j.amjmed.2019.02.016. Epub 2019 Mar 8. PubMed PMID: 30853474.