Roberto Bolli, M.D., FAHA

Professor of Medicine, Physiology and Biophysics; Chief, Division of Cardiovascular Medicine; Executive Vice Chair, Department of Medicine; Jewish Hospital Heart and Lung Institute Distinguished Chair in Cardiology; Distinguished University Scholar; Scientific Director, Cardiovascular Innovation Institute

Department of Medicine


401 East Chestnut St, Ste. 310, Louisville, KY 40202 502-852-7959(academic) 502-813-6500 (clinical)

Clinical Expertise

Cardiology; Cardiovascular Disease

Board Certification

  • American Board of Internal Medicine - Internal Medicine / Cardiovascular Disease

Education and Training

  • Medical School: University of Perugia, Italy

  • Residency: Baylor College of Medicine

  • Fellowship: National Institutes of Health; Baylor College of Medicine

Recent Publications

  • Madonna R, Bolli R, Rokosh G, De Caterina R. Targeting phosphatidylinositol 3-kinase-Akt through hepatocyte growth factor for cardioprotection. J Cardiovasc Med (Hagerstown). 2013 Apr;14(4):249-53. doi: 10.2459/JCM.0b013e3283542017. PubMed PMID: 22609872.

  • Loughran JH, Chugh AR, Ismail I, Bolli R. Stem cell therapy: promising treatment in heart failure? Curr Heart Fail Rep. 2013 Mar;10(1):73-80. doi: 10.1007/s11897-012-0128-2. PubMed PMID: 23354783.

  • Bolli R. The 10 most read articles published in circulation research in 2012. Circ Res. 2013 Feb 15;112(4):586-90. doi: 10.1161/CIRCRESAHA.113.300980. PubMed PMID: 23410877.

  • Bolli R. Preamble to the profile of Dr Abboud and reflections on the future of American medical education. Circ Res. 2013 Feb 1;112(3):418-20. doi: 10.1161/CIRCRESAHA.113.300884. PubMed PMID: 23371899.

  • Loughran JH, Elmore JB, Waqar M, Chugh AR, Bolli R. Cardiac stem cells in patients with ischemic cardiomyopathy: discovery, translation, and clinical investigation. Curr Atheroscler Rep. 2012 Oct;14(5):491-503. doi: 10.1007/s11883-012-0273-9. PubMed PMID: 22847771.

  • Cai C, Teng L, Vu D, He JQ, Guo Y, Li Q, Tang XL, Rokosh G, Bhatnagar A, Bolli R. The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against  apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release. J Biol Chem. 2012 Sep 28;287(40):33720-32. Epub 2012 Aug 9. PubMed PMID: 22879597; PubMed Central PMCID: PMC3460469.

  • Chugh AR, Beache GM, Loughran JH, Mewton N, Elmore JB, Kajstura J, Pappas P, Tatooles A, Stoddard MF, Lima JA, Slaughter MS, Anversa P, Bolli R. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation. 2012 Sep 11;126(11 Suppl 1):S54-64. PubMed PMID: 22965994; PubMed Central PMCID: PMC3448934.

  • Guo Y, Flaherty MP, Wu WJ, Tan W, Zhu X, Li Q, Bolli R. Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice. Basic Res Cardiol. 2012 Sep;107(5):288. doi: 10.1007/s00395-012-0288-y. Epub 2012 Aug 3. PubMed PMID: 22864681.

  • Madonna R, Bolli R, Rokosh G, De Caterina R. Long-Term Engraftment and Angiogenic Properties of Lentivirally Transduced Adipose Tissue-Derived Stromal Cells. Mol Biotechnol. 2012 Apr 11. [Epub ahead of print] PubMed PMID: 22492300.

  • Zafir A, Readnower R, Long BW, McCracken J, Aird A, Alvarez A, Cummins TD, Li Q, Hill BG, Bhatnagar A, Prabhu SD, Bolli R, Jones SP. Protein O-GlcNAcylation Is a Novel Cytoprotective Signal in Cardiac Stem Cells. Stem Cells. 2012 Apr;31(4):765-75. doi: 10.1002/stem.1325. PubMed PMID: 23335157.

  • Guo Y, Sanganalmath SK, Wu W, Zhu X, Huang Y, Tan W, Ildstad ST, Li Q, Bolli R. Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2012 Mar;107(2):253. doi: 10.1007/s00395-012-0253-9. Epub 2012 Feb 21. PubMed PMID: 22351077.

  • Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, Beache GM, Wagner SG, Leri A, Hosoda T, Sanada F, Elmore JB, Goichberg P, Cappetta D, Solankhi NK, Fahsah I, Rokosh DG, Slaughter MS, Kajstura J, Anversa P. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011 Nov 26;378(9806):1847-57. doi: 10.1016/S0140-6736(11)61590-0. Epub 2011 Nov 14. PubMed PMID: 22088800.