Igor Zelko, Ph.D.

Igor Zelko, Ph.D.

Igor Zelko, Ph.D.

Igor N. Zelko, Ph.D.

  • Assistant Professor of Medicine

Donald Baxter Building, Ste. 221E
Louisville, KY 40202

502-852-5841- Academic Office
502-852-7632- Research Office


Areas of Research Interest

  • Gene Regulation
  • Bleomycin-Induced Pulmonary Fibrosis

 

Recent Publications

    • Stepp MW, Folz RJ, Yu J, Zelko IN. The c10orf10 gene product is a new link between oxidative stress and autophagy. Biochim Biophys Acta. 2014 Feb 14;1843(6):1076-1088. doi: 10.1016/j.bbamcr.2014.02.003. [Epub ahead of print] PubMed PMID: 24530860.
    • Zelko IN, Stepp MW, Folz RJ. A bioluminescent transgenic mouse model: real-time in vivo imaging of antioxidant EC-SOD gene expression and regulation by interferon gamma. Gene. 2013 Nov 1;530(1):75-82. doi: 10.1016/j.gene.2013.07.012. Epub 2013 Jul 22. PubMed PMID: 23886589.
    • Zelko IN, Stepp MW, Vorst AL, Folz RJ. Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. Am J Respir Cell Mol Biol. 2011 Nov;45(5):953-61. doi: 10.1165/rcmb.2011-0012OC. Epub 2011 Apr 14. PubMed PMID: 21493784; PubMed Central PMCID: PMC3262691.
    • Zelko IN, Folz RJ. Extracellular superoxide dismutase attenuates release of pulmonary hyaluronan from the extracellular matrix following bleomycin exposure. FEBS Lett. 2010 Jul 2;584(13):2947-52. doi: 10.1016/j.febslet.2010.05.025. Epub 2010 May 21. PubMed PMID: 20493858; PubMed Central PMCID: PMC2892677.
    • Zelko IN, Mueller MR, Folz RJ. CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression. Free Radic Biol Med. 2010 Apr 1;48(7):895-904. doi: 10.1016/j.freeradbiomed.2010.01.007. Epub 2010 Jan 14. PubMed PMID: 20079429; PubMed Central PMCID: PMC2838251.
    • Itoh S, Ozumi K, Kim HW, Nakagawa O, McKinney RD, Folz RJ, Zelko IN, Ushio-Fukai M, Fukai T. Novel mechanism for regulation of extracellular SOD transcription and activity by copper: role of antioxidant-1. Free Radic Biol Med. 2009 Jan 1;46(1):95-104. doi: 10.1016/j.freeradbiomed.2008.09.039. Epub 2008 Oct 21. PubMed PMID: 18977292; PubMed Central PMCID: PMC2630370.
    • Zelko IN, Mueller MR, Folz RJ. Transcription factors sp1 and sp3 regulate expression of human extracellular superoxide dismutase in lung fibroblasts. Am J Respir Cell Mol Biol. 2008 Aug;39(2):243-51. doi: 10.1165/rcmb.2007-0378OC. Epub 2008 Feb 28. PubMed PMID: 18314536; PubMed Central PMCID: PMC2542458.
    • Liu JQ, Zelko IN, Erbynn EM, Sham JS, Folz RJ. Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox). Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L2-10. Epub 2005 Aug 5. PubMed PMID: 16085672.
    • Park JW, Qi WN, Cai Y, Zelko I, Liu JQ, Chen LE, Urbaniak JR, Folz RJ. Skeletal muscle reperfusion injury is enhanced in extracellular superoxide dismutase knockout mouse. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H181-7. Epub 2005 Mar 18. PubMed PMID: 15778274.
    • Zelko IN, Folz RJ. Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression. Endocrinology. 2005 Jan;146(1):332-40. Epub 2004 Sep 16. PubMed PMID: 15375030.