Novel Therapies in Alcoholic Hepatitis: Defeat Alcoholic Steatohepatitis (DASH)

Novel Therapies in Alcoholic Hepatitis: Defeat Alcoholic Steatohepatitis (DASH)

The DASH-Clinical and Translational U01 Consortium was very well represented at the Research Society on Alcoholism meeting June 20-24, 2015, in San Antonio. There were a total of 17 abstract presentations.

Dr. Laura Nagy presented two talks: "Adipose Tissue and Complement: Contribution to Alcohol-Induced Inflammation" in the session on Novel Insights into Inflammatory Mechanisms of Alcohol-Induced tissue Injury, and "Inflammation and Cell Death in ALD" at the 3rd Alcohol and Cancer Conference.

See list of DASH presentations

 

Investigators for the DASH Consortium presented the following abstracts at the 38th annual Research Society on Alcoholism Scientific Meeting held June 20-24, 2015:

  • PDE4B Inhibition Significantly Attenuates Alcohol-Induced Hepatic Lipid Peroxidation and Prevent Inactivation of AmpK - Diana Avila

  • Oral Administration of Tributyrin Targets The "Gut-Liver" Axis and Attenuates Alcoholic Liver Disease (ALD) - Shirish Barve, Hridgandh Donde

  • Embryonic Exposure to Ethanol Increases The Susceptibility of Larval Zebrafish to Chemically Induced Seizures - Shao-Yu Chen, Keling Wang

  • Sulforaphane Protects Against Ethanol-Induced Apoptosis in Neural Crest Cells by Epigenetic Modulation of BCL2 Gene Expression - Shao-Yu Chen, Xiaopan Chen

  • Up-Regulation of Siah1 by Ethanol Triggers Apoptosis in Neural Crest Cells Through P38 MapK-Mediated Activation of P53 Signaling Pathway - Shao-Yu Chen, Fuqiang Yuan

  • Lipid-Derived Aldehyde, Acrolein, is a Critical Mediator of Alcohol-Induced Gut-Liver Injury in Alcoholic Liver Disease - Wei-Yang Chen, Swati Joshi-Barve

  • FGF21 Mediates Alcohol-Induced Adipose Tissue Lipolysis by Activation of Systemic Release of Catecholamine in Mice - Wenke Feng

  • Ethanol Inhibits Transcriptionally Permissive Promoter Histone Modifications and Decreases Il-2 Expression in Activated Human CD4+ T Lymphocytes

  • Alcohol-Induced Neuro-Inflammation is Critically Regulated by Phosphodiesterase 4B (PDE4B) - Leila Gobejishvili

  • Lipoxygenase Inhibition Ameliorates Alcohol-Induced Liver Injury and Inflammation in a Mouse Model of Alcoholic Liver Disease - Huillin Liu, Irina A Kirpich

  • Improvement of Inflammatory Biomarkers, Liver Fibrosis & Clinical Parameters With 3 Months Zinc Sulfate For Alcoholic Cirrhosis-Zac Clinical Trial - Mohammad Mohammad

  • Role of Drinking History and Sex-Differences in Metabolites Involved in Inflammation in Alcohol Dependents - Vatsalya Vatsalya

  • Role of Family History of Alcoholism and Recent Drinking on Subjective & Objective Responses to Acute IV Alcohol: Clamp and Biphasic Exposure Profiles - Vatsalya Vatsalya

  • Association of Liver Injury Exacerbation and Fatty Acids of W-6 and W-3 Inflammatory Pathways in Early-Stage HIV-Diagnosed Alcoholic Patients - Vatsalya Vatsalya

  • Mixed Lineage Protein Kinase 3 Contributes to Ethanol-Induced Liver Injury - Sanjoy Roychowdhury, Megan R. McMullen, Laura E. Nagy

  • Specific-Sized Hyaluronan Fragments Differentially Regulate LPS Signal Transduction in Kupffer Cells After Ethanol Feeding to Rats - Paramananda Saikia, Katherine A. Pollard, Megan R. McMullen, Laura E. Nagy

  • Factor D Contributes to Hepatoprotection from Chronic Ethanol-Induced Liver Injury in Mice - R.L. Smathers McCullough, S. Roychowdhury, M.R. McMullen, Laura E. Nagy