U of L GI well represented at AASLD

U of L GI well represented at AASLD

U of L GI well represented at AASLD

Craig J. McClain, M.D., discusses the similarities and key differences in alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) during a postgraduate course session at the AASLD Liver Meeting.

Postgraduate course examines inflammation and steatohepatitis

Members of the University of Louisville Division of Gastroenterology, Hepatology & Nutrition and their collaborators presented the following abstracts at the 2014 American Association for the Study of Liver Disease (AASLD) Liver Meeting held November 7-11, 2014 in Boston:

  • Transient Receptor Potential Vanilloid 1 Gene Deficiency Ameliorates Hepatic Injury in a Mouse Model of Chronic-Binge-Induced Alcoholic Liver Disease - Irina Kirpich, Huilin Liu, K. Cameron Falkner, Juliane I. Beier, Gavin E. Arteel, Christopher Ramsden, Ariel E. Feldstein, Craig McClain
  • Post-Transplant Hepatitis C Reinfection Following Prolonged Pre-transplant Viral Suppression with Sofosbuvir Plus Ribavirin in a Hepatocellular Carcinoma Patient Wait-Listed For Orthotopic Liver Transplantation - Eric Davis, Neil Crittenden, Barbra Goshko, Matt Cave
  • Single Center Experience with Simeprevir/Sofosbuvir Combination Therapy for Recurrent Hepatitis C Virus Infection in Liver Transplant Recipients - Neil Crittenden, Eric Davis, Luis Marsano, Craig McClain, Ashutosh Barve, Barbra Goshko, Rob Tatum, Mike Hughes, Chris Jones, Michael R Marvin, Matt Cave
  • The protective role of CAR and PXR in Aroclor 1260-induced Steatohepatitis - B. Wahlang,  K.C. Falkner, M. Song, H. Clair, R. Prough, and M. Cave
  • Suspected Toxicant Associated Steatohepatitis (TASH) in Residents Living Near an Abandoned Chemical Manufacturing Complex - I.Kirpich, M.Mohammad, K.C.Falkner, H.B. Clair, G.E. Arteel, R.A. Prough, M.Cave
  • Phosphodiesterase 4 (PDE4) plays a significant role in alcohol induced dysregulation of lipid metabolism and development of hepatic steatosis - D. V. Avila, J. Zhang, C. J. McClain, S. Barve, and L.Gobejishvili
  • Lipid-derived aldehyde, acrolein, is a critical mediator of alcohol-induced gut-liver injury in alcoholic liver disease - Wei-Yang Chen, Jingwen Zhang, Shirish Barve, Craig McClain, and Swati Joshi-BarveExposure to Vinyl Chloride Metabolites Exacerbates Liver Injury Caused by High Fat Diet in Mice - Lisanne C Anders, Amanda N Douglas, Adrienne M Bushau, Keith C Falkner, Gavin E Arteel, Matt Cave, Craig J McClain and Juliane I Beier
  • 9(S)-hydroxy-octadecadienoic acid (HODE) enhances interleukin-1β production of PBMCs from alcoholic liver cirrhosis patients by activation of TRPV1 - Qifa Xie, Mohammad Mohammad, Matthew Cave, Shirish Barve, Irina Kirpich, Craig McClain
  • Oral Administration of Tributyrin Attenuates Chronic Ethanol-Induced Hepatic Steatosis, Inflammation and Injury - H. Donde, J. Zhang, S. Ghare, L. Gobejishvili, S. Joshi-Barve, V. Vatsalya, C.J. McClain and S. Barve
  • Interactions between the gut permeability, blood endotoxemia and liver injury in alcoholic patients during detoxification - Irina A.Kirpich, John Umhau, Vatsalya Vatsalya, Melanie Schwandt, Monte Phillips, Timothy Lionetti,  K.Cameron Falkner, Lucy Zhang, Catey Harwell, David T.George, Markus A. Heilig, Craig J. McClain
  • Fibroblast Growth Factor 21 Deficiency Exacerbates Chronic Alcohol-Induced Hepatic Steatosis and Injury in Mice - Cuiqing Zhao, Liming Liu, Fengyuan Li, Craig McClain, Wenke Feng
  • Serum fibroblast growth factor 19 levels are increased in subjects with alcoholic cirrhosis and positively associated with serum total bile acid levels - Cuiqing Zhao, Mohammad Mohammad, Liming Liu, Keith C. Falkner, Zhanxiang Zhou, Craig J. McClain, Wenke Feng, Matthew C. Cave
  • Zinc Sulfate for Alcoholic Cirrhosis (ZAC) Clinical Trial-Interim Analysis of Clinical Parameters, Intestinal Permeability and Liver Fibrosis Biomarkers - Ming Song, Mohammad K. Mohammad, Cam Falkner, Craig J. McClain, Matthew C. Cave
  • Zinc Sulfate for Alcoholic Cirrhosis (ZAC) Clinical Trial-Interim Analysis of Liver Injury/Inflammation Biomarkers - Mohammad K. Mohammad, Ming Song, Falkner K.C., Craig J. McClain, Matthew C. Cave
  • Elevated biomarker-indicated liver disease and pro-inflammatory cytokines are associated with environmental PCB exposure in Anniston, Alabama - H.B. Clair, K.C. Falkner, B. Wahlang, R.A. Prough, and M. Cave
  • Proteomics analysis of liver from mice with high fat diet-induced fatty liver disease identifies inhibition of HNF4a as a mechanism by which arsenic promotes progression to steatohepatitis - Walter H. Watson, Tom J. Burke, Veronica L. Massey, Gavin E. Arteel, Michael L. Merchant
  • Quetiapine Fumarate XR showed better clinical management in elevated liver injury during titration phase in very heavy drinkers - H. Donde, V. Vatsalya, C. J. McClain, S. S. Barve
  • Lack of antiviral therapy response is associated with elevated circulating levels of cytokeratin-18 and inflammatory cytokine IL-8 in patients with chronic hepatitis C - Bryan Lamoreau, Smita Ghare, Shirish Barve, Craig McClain, and Swati Joshi-Barve