Wenke Feng, Ph.D.

Wenke Feng, Ph.D.

Wenke Feng, M.D.

Wenke Feng, Ph.D.

  • Associate Professor of Medicine

502-852-6991 - Academic Office


  • B.Sc.: Shaanxi Normal University (Xi'an, China)
  • M.Sc.: Northwest University (Xi'an, China)
  • Ph.D.: University of Natural Resources and Life Sciences (Vienna, Austria)


Research Interests

  • Mechanisms of Alcoholic Liver Disease
  • Mechanisms of Non-alcoholic Steatohepatitis
  • Tissue Hypoxia and Diabetic Complications


Featured Publications

  • Yuan F, Chen X, Liu J, Feng W, Cai L, Wu X, Chen SY. Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos. Exp Neurol. 2018 Feb;300:60-66. doi: 10.1016/j.expneurol.2017.10.020. Epub 2017 Oct 22. PubMed PMID: 29069573; PubMed Central PMCID: PMC5745274.
  • Kong X, Yang Y, Ren L, Shao T, Li F, Zhao C, Liu L, Zhang H, McClain CJ, Feng W. Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling. Sci Rep. 2017 Aug 24;7(1):9292. doi: 10.1038/s41598-017-09045-z. PubMed PMID: 28839246; PubMed Central PMCID: PMC5571015.
  • Yuan F, Chen X, Liu J, Feng W, Wu X, Chen SY. Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway. Arch Toxicol. 2017 Feb;91(2):775-784. doi: 10.1007/s00204-016-1746-3. Epub 2016 Jun 8. PubMed PMID: 27270636; PubMed Central PMCID: PMC5428080.
  • Liu L, Zhao C, Yang Y, Kong X, Shao T, Ren L, Zhuang X, Yin B, Dryden G, McClain C, Luan W, Feng W. Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis. Gastroenterol Res Pract. 2017;2017:3089378. doi: 10.1155/2017/3089378. Epub 2017 May 11. PubMed PMID: 28584524; PubMed Central PMCID: PMC5444037.
  • Cave MC, Clair HB, Hardesty JE, Falkner KC, Feng W, Clark BJ, Sidey J, Shi H, Aqel BA, McClain CJ, Prough RA. Nuclear receptors and nonalcoholic fatty liver disease. Biochim Biophys Acta. 2016 Sep;1859(9):1083-99. doi: 10.1016/j.bbagrm.2016.03.002. Epub 2016 Mar 4. Review. PubMed PMID: 26962021; PubMed Central PMCID: PMC5149456.
  • Liu Y, Zhao C, Xiao J, Liu L, Zhang M, Wang C, Wu G, Zheng MH, Xu LM, Chen YP, Mohammadi M, Chen SY, Cave M, McClain C, Li X, Feng W. Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. Sci Rep. 2016 Aug 8;6:31026. doi: 10.1038/srep31026. PubMed PMID: 27498701; PubMed Central PMCID: PMC4976373.
  • Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Kronenberg M, Zhang HG. Correction: Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells. J Immunol. 2016 Jun 1;196(11):4832. doi: 10.4049/jimmunol.1600479. PubMed PMID: 27207807.
  • Kirpich IA, Petrosino J, Ajami N, Feng W, Wang Y, Liu Y, Beier JI, Barve SS, Yin X, Wei X, Zhang X, McClain CJ. Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease. Am J Pathol. 2016 Apr;186(4):765-76. doi: 10.1016/j.ajpath.2015.11.017. PubMed PMID: 27012191.
  • Zhang J, Cheng Y, Gu J, Wang S, Zhou S, Wang Y, Tan Y, Feng W, Fu Y, Mellen N, Cheng R, Ma J, Zhang C, Li Z, Cai L. Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice. Clin Sci (Lond). 2016 Apr;130(8):625-41. doi: 10.1042/CS20150623. Epub 2016 Jan 21. PubMed PMID: 26795437.
  • Cheng Y, Zhang J, Guo W, Li F, Sun W, Chen J, Zhang C, Lu X, Tan Y, Feng W, Fu Y, Liu GC, Xu Z, Cai L. Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy. Free Radic Biol Med. 2016 Apr;93:94-109. doi: 10.1016/j.freeradbiomed.2016.02.002. Epub 2016 Feb 2. PubMed PMID: 26849944.