Walter H. "Bert" Watson, Ph.D.

Walter H. "Bert" Watson, Ph.D.

Walter Watson

  • Assistant Professor of Medicine
550 South Jackson Street, Ste. A3K00
Louisville, KY 40202

502-852-7944 - Academic Office


  • B.A. (Chemistry): Emory University

  • Ph.D. (Toxicology): University of Kentucky


Research Interests

  • Oxidative stress and redox signaling

  • Mechanistic toxicology

  • Alcoholic and nonalcoholic fatty liver disease

Featured Publications

  • Zheng Y, Ritzenthaler JD, Burke TJ, Otero J, Roman J, Watson WH. Age-dependent oxidation of extracellular cysteine/cystine redox state (E(h)(Cys/CySS)) in mouse lung fibroblasts is mediated by a decline in Slc7a11 expression. Free Radic Biol Med. 2018 Apr;118:13-22. doi: 10.1016/j.freeradbiomed.2018.02.026. Epub 2018 Feb 16. PubMed PMID: 29458149; PubMed Central PMCID: PMC5884717.
  • Tyo KM, Vuong HR, Malik DA, Sims LB, Alatassi H, Duan J, Watson WH, Steinbach-Rankins JM. Multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of HIV-1 and HSV-2 infections in vitro. Int J Pharm. 2017 Oct 5;531(1):118-133. doi: 10.1016/j.ijpharm.2017.08.061. Epub 2017 Aug 7. PubMed PMID: 28797967; PubMed Central PMCID: PMC5812024.
  • Barve S, Chen SY, Kirpich I, Watson WH, Mcclain C. Development, Prevention, and Treatment of Alcohol-Induced Organ Injury: The Role of Nutrition. Alcohol Res. 2017;38(2):289-302. Review. PubMed PMID: 28988580; PubMed Central PMCID: PMC5513692.
  • Watson WH, Ritzenthaler JD, Roman J. Lung extracellular matrix and redox regulation. Redox Biol. 2016 Aug;8:305-15. doi: 10.1016/j.redox.2016.02.005. Epub 2016 Feb 18. Review. PubMed PMID: 26938939; PubMed Central PMCID: PMC4777985.
  • Watson WH, Burke TJ, Zelko IN, Torres-González E, Ritzenthaler JD, Roman J. Differential Regulation of the Extracellular Cysteine/Cystine Redox State (EhCySS) by Lung Fibroblasts from Young and Old Mice. Oxid Med Cell Longev. 2016;2016:1561305. doi: 10.1155/2016/1561305. Epub 2016 Aug 25. PubMed PMID: 27642492; PubMed Central PMCID: PMC5014973.
  • Li L, Fath MA, Scarbrough PM, Watson WH, Spitz DR. Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer. Redox Biol. 2015;4:127-35. doi: 10.1016/j.redox.2014.12.001. Epub 2014 Dec 10. PubMed PMID: 25560241; PubMed Central PMCID: PMC4309850.
  • Watson WH, Burke TJ, Doll MA, McClain CJ. S-adenosylhomocysteine inhibits NF-κB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity. Alcohol Clin Exp Res. 2014 Apr;38(4):889-96. doi: 10.1111/acer.12315. Epub 2013 Nov 13. PubMed PMID: 24224954; PubMed Central PMCID: PMC4035050.
  • Shi X, Wei X, Koo I, Schmidt RH, Yin X, Kim SH, Vaughn A, McClain CJ, Arteel GE, Zhang X, Watson WH. Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced Fatty liver disease. J Proteome Res. 2014 Feb 7;13(2):547-554. doi: 10.1021/pr400719u. Epub 2013 Dec 17. PubMed PMID: 24328084; PubMed Central PMCID: PMC3946282.
  • Wei X, Shi X, Koo I, Kim S, Schmidt RH, Arteel GE, Watson WH, McClain C, Zhang X. MetPP: a computational platform for comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry-based metabolomics. Bioinformatics. 2013 Jul 15;29(14):1786-92. doi: 10.1093/bioinformatics/btt275. Epub 2013 May 11. PubMed PMID: 23665844; PubMed Central PMCID: PMC3702250.
  • Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O'Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA. GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice. Diabetes. 2012 Dec;61(12):3094-105. doi: 10.2337/db12-0072. Epub 2012 Jul 17. PubMed PMID: 22807033; PubMed Central PMCID: PMC3501888.