Walter H. Watson

Walter H. Watson


Walter H. Watson, Ph.D.

Walter H. Watson, Ph.D.

  • Assistant Professor of Medicine

502-852-6991 - Academic Office


Education

  • B.A. (Chemistry): Emory University

  • Ph.D. (Toxicology): University of Kentucky

 

Research Interests

  • Oxidative stress and redox signaling

  • Mechanistic toxicology

  • Alcoholic and nonalcoholic fatty liver disease


Recent Publications

  • Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR. Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radic Biol Med. 2012 Jan 15;52(2):436-43.

  • Tan M, Schmidt RH, Beier JI, Watson WH, Zhong H, States JC, Arteel GE. Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice. Toxicol Appl Pharmacol. 2011 Dec 15;257(3):356-64.

  • Lai IK, Chai Y, Simmons D, Watson WH, Tan R, Haschek WM, Wang K, Wang B, Ludewig G, Robertson LW. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci. 2011 Nov;124(1):202-14.

  • Heilman JM, Burke TJ, McClain CJ, Watson WH. Transactivation of gene expression by NF-κB is dependent on thioredoxin reductase activity. Free Radic Biol Med. 2011 Oct 15;51(8):1533-42.

  • Stanley BA, Sivakumaran V, Shi S, McDonald I, Lloyd D, Watson WH, Aon MA, Paolocci N. Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria. J Biol Chem. 2011 Sep 23;286(38):33669-77.