Smita S. Ghare, Ph.D.

Smita Ghare

  • Instructor in Medicine

502-852-6991 - Academic Office


  • B.Sc.: Wilson College, University of Mumbai (India)
  • M.Sc.: LTMM College, University of Mumbai (India)
  • Ph.D.: University of Louisville


Research Interests

  • Epigenetics
  • HIV and Liver Disease


Featured Publications

  • Ghare SS, Donde H, Chen WY, Barker DF, Gobejishvilli L, McClain CJ, Barve SS, Joshi-Barve S. Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26. PubMed PMID: 27238871; PubMed Central PMCID: PMC4938746.
  • Chen WY, Zhang J, Ghare S, Barve S, McClain C, Joshi-Barve S. Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. Cell Mol Gastroenterol Hepatol. 2016 May 27;2(5):685-700. doi: 10.1016/j.jcmgh.2016.05.010. eCollection 2016 Sep. PubMed PMID: 28119953; PubMed Central PMCID: PMC5042858.
  • Gobejishvili L, Ghare S, Khan R, Cambon A, Barker DF, Barve S, McClain C, Hill D. Misoprostol modulates cytokine expression through a cAMP pathway: Potential therapeutic implication for liver disease. Clin Immunol. 2015 Dec;161(2):291-9. doi: 10.1016/j.clim.2015.09.008. Epub 2015 Sep 25. PubMed PMID: 26408955; PubMed Central PMCID: PMC4658275.
  • Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C, Joshi-Barve S. Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol Sci. 2015 Feb;143(2):242-55. doi: 10.1093/toxsci/kfu233. Review. PubMed PMID: 25628402; PubMed Central PMCID: PMC4306719.
  • Fernandez-Botran R, Joshi-Barve S, Ghare S, Barve S, Young M, Plankey M, Bordon J. Systemic cytokine and interferon responsiveness Patterns in HIV and HCV mono and co-infections. J Interferon Cytokine Res. 2014 Nov;34(11):885-93. doi: 10.1089/jir.2014.0006. Epub 2014 Jun 23. PubMed PMID: 24955730; PubMed Central PMCID: PMC4217006.
  • Ghare SS, Joshi-Barve S, Moghe A, Patil M, Barker DF, Gobejishvili L, Brock GN, Cave M, McClain CJ, Barve SS. Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells. J Immunol. 2014 Jul 1;193(1):412-21. doi: 10.4049/jimmunol.1400055. Epub 2014 Jun 4. PubMed PMID: 24899502; PubMed Central PMCID: PMC5096587.
  • Kirpich I, Zhang J, Gobejishvili L, Kharebava G, Barker D, Ghare S, Joshi-Barve S, McClain CJ, Barve S. Binge ethanol-induced HDAC3 down-regulates Cpt1α expression leading to hepatic steatosis and injury. Alcohol Clin Exp Res. 2013 Nov;37(11):1920-9. doi: 10.1111/acer.12172. Epub 2013 Jul 26. PubMed PMID: 23905631; PubMed Central PMCID: PMC3975907.
  • Kirpich I, Ghare S, Zhang J, Gobejishvili L, Kharebava G, Barve SJ, Barker D, Moghe A, McClain CJ, Barve S. Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3. Alcohol Clin Exp Res. 2012 Sep;36(9):1578-86. doi: 10.1111/j.1530-0277.2012.01751.x. Epub 2012 Feb 29. PubMed PMID: 22375794; PubMed Central PMCID: PMC4867116.
  • Ghare S, Patil M, Hote P, Suttles J, McClain C, Barve S, Joshi-Barve S. Ethanol inhibits lipid raft-mediated TCR signaling and IL-2 expression: potential mechanism of alcohol-induced immune suppression. Alcohol Clin Exp Res. 2011 Aug;35(8):1435-44. doi: 10.1111/j.1530-0277.2011.01479.x. Epub 2011 Apr 4. PubMed PMID: 21463338; PubMed Central PMCID: PMC3143276.
  • Moghe A, Joshi-Barve S, Ghare S, Gobejishvili L, Kirpich I, McClain CJ, Barve S. Histone modifications and alcohol-induced liver disease: are altered nutrients the missing link? World J Gastroenterol. 2011 May 28;17(20):2465-72. doi: 10.3748/wjg.v17.i20.2465. Review. PubMed PMID: 21633651; PubMed Central PMCID: PMC3103804.