Leila Gobejishvili

Leila Gobejishvili


Leila Gobejishvili, Ph.D.






Leila Gobejishvili, Ph.D.

  • Assistant Professor of Medicine

502-852-6991 - Academic Office


Education

  • B.Sc.: Tblisi State University (Republic of Georgia)

  • M.Sc.: Tblisi State University (Republic of Georgia)

  • Ph.D.: Institute of Physiology, Georgian Academy of Sciences (Republic of Georgia)

 

Research Interests

  • Alcohol induced changes in innate immunity

  • Alcohol mediated epigenetic changes of pro-inflammatory cytokines

  • Role of phosphodiesterases in priming of monocytes and development of liver injury/fibrosis


Recent Publications

  • Gobejishvili L, Barve S, Breitkopf-Heinlein K, Li Y, Zhang J, Avila DV, Dooley S, McClain CJ. Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4. J Pharmacol Exp Ther. 2013 Jul 25. [Epub ahead of print]

  • Kirpich I, Zhang J, Gobejishvili L, Kharebava G, Barker D, Ghare S, Joshi-Barve S, McClain CJ, Barve S. Binge Ethanol-Induced HDAC3 Down-Regulates Cpt1α Expression Leading to Hepatic Steatosis and Injury. Alcohol Clin Exp Res. 2013 Jul 26. doi: 10.1111/acer.12172. [Epub ahead of print]

  • Smart L, Gobejishvili L, Crittenden N, Barve S, McClain CJ. Alcoholic Hepatitis: Steroids vs. Pentoxifylline. Curr Hepat Rep. 2013 Mar 1;12(1):59-65.

  • Kirpich I, Ghare S, Zhang J, Gobejishvili L, Kharebava G, Barve SJ, Barker D, Moghe A, McClain CJ, Barve S. Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3. Alcohol Clin Exp Res. 2012 Sep;36(9):1578-86. doi: 10.1111/j.1530-0277.2012.01751.x. Epub 2012 Feb 29.

  • Gobejishvili L, Avila DV, Barker DF, Ghare S, Henderson D, Brock GN, Kirpich IA, Joshi-Barve S, Mokshagundam SP, McClain CJ, Barve S. S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway. J Pharmacol Exp Ther. 2011 May;337(2):433-43.