Irina A. Kirpich, Ph.D.

Irina A. Kirpich, Ph.D.

  • Associate Professor of Medicine

502-852-1127 - Academic Office

Educational Background

  • B.Sc.: Lugansk State University (Ukraine)
  • M.Sc.: Lugansk State University (Ukraine)
  • Ph.D.: Pomor State University (Russia)
  • D.Biol.Sc.: Northern State University (Russia)


Research Interests

  • Gut-Liver interactions in alcoholic and nonalcoholic liver disease
  • Alcohol and dietary fat mediated intestinal and liver injury
  • Gut barrier, microbiome, probiotics
  • Epigenetics and hepatic steatosis
  • Oxidized metabolites of linoleic acid (OXLAMs)

Featured Publications

  • Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. Mechanisms of Environmental Contributions to Fatty Liver Disease. Curr Environ Health Rep. 2019 May 27. doi: 10.1007/s40572-019-00232-w. [Epub ahead of print] Review. PubMed PMID: 31134516.
  • Kirpich IA, Warner DR, Feng W, Joshi-Barve S, McClain CJ, Seth D, Zhong W, Zhou Z, Osna NA, Kharbanda KK. Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition: Summary of the ISBRA 2018 Symposium. Alcohol. 2019 May 23. pii: S0741-8329(19)30069-2. doi: 10.1016/j.alcohol.2019.05.004. [Epub ahead of print] Review. PubMed PMID: 31129175.
  • Kirpich IA, McClain CJ. Introduction to the Virtual Issue "Translational Studies in AUD: Liver Disease". Alcohol Clin Exp Res. 2019 Apr;43(4):593-596. doi: 10.1111/acer.13967. Epub 2019 Feb 27. PubMed PMID: 30694554; PubMed Central PMCID: PMC6443476.
  • Ramsden CE, Hennebelle M, Schuster S, Keyes GS, Johnson CD, Kirpich IA, Dahlen JE, Horowitz MS, Zamora D, Feldstein AE, McClain CJ, Muhlhausler BS, Makrides M, Gibson RA, Taha AY. Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1206-1213. doi: 10.1016/j.bbalip.2018.07.007. Epub 2018 Jul 25. PubMed PMID: 30053599; PubMed Central PMCID: PMC6180905.
  • Warner DR, Liu H, Ghosh Dastidar S, Warner JB, Prodhan MAI, Yin X, Zhang X, Feldstein AE, Gao B, Prough RA, McClain CJ, Kirpich IA. Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease. PLoS One. 2018 Sep 26;13(9):e0204119. doi: 10.1371/journal.pone.0204119. eCollection 2018. PubMed PMID: 30256818; PubMed Central PMCID: PMC6157879.
  • Schuster S, Johnson CD, Hennebelle M, Holtmann T, Taha AY, Kirpich IA, Eguchi A, Ramsden CE, Papouchado BG, McClain CJ, Feldstein AE. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. J Lipid Res. 2018 Sep;59(9):1597-1609. doi: 10.1194/jlr.M083741. Epub 2018 Jul 3. PubMed PMID: 30084831; PubMed Central PMCID: PMC6121934.
  • Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA. Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules. 2018 Mar 26;8(2). pii: E16. doi: 10.3390/biom8020016. PubMed PMID: 29587455; PubMed Central PMCID: PMC6022870.
  • Ghosh Dastidar S, Warner JB, Warner DR, McClain CJ, Kirpich IA. Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration. Biomolecules. 2018 Jan 13;8(1). pii: E3. doi: 10.3390/biom8010003. Review. PubMed PMID: 29342874; PubMed Central PMCID: PMC5871972.
  • Kirpich I, McClain C. More Alcohol, More Liver Injury: Not Always True. Alcohol Alcohol. 2017 Nov 1;52(6):627-628. doi: 10.1093/alcalc/agx064. Review. PubMed PMID: 29036522; PubMed Central PMCID: PMC6355099.
  • Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA. Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice. Am J Pathol. 2017 Oct;187(10):2232-2245. doi: 10.1016/j.ajpath.2017.06.008. PubMed PMID: 28923202; PubMed Central PMCID: PMC5808136.