Irina A. Kirpich, Ph.D.

Irina A. Kirpich, Ph.D.

Irina A. Kirpich, Ph.D.

  • Associate Professor of Medicine

502-852-1127 - Academic Office

Educational Background

  • B.Sc.: Lugansk State University (Ukraine)
  • M.Sc.: Lugansk State University (Ukraine)
  • Ph.D.: Pomor State University (Russia)
  • D.Biol.Sc.: Northern State University (Russia)


Research Interests

  • Gut-Liver interactions in alcoholic and nonalcoholic liver disease
  • Alcohol and dietary fat mediated intestinal and liver injury
  • Gut barrier, microbiome, probiotics
  • Epigenetics and hepatic steatosis
  • Oxidized metabolites of linoleic acid (OXLAMs)

Featured Publications

  • Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA. Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules. 2018 Mar 26;8(2). pii: E16. doi: 10.3390/biom8020016. PubMed PMID: 29587455.
  • Ghosh Dastidar S, Warner JB, Warner DR, McClain CJ, Kirpich IA. Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration. Biomolecules. 2018 Jan 13;8(1). pii: E3. doi: 10.3390/biom8010003. Review. PubMed PMID: 29342874; PubMed Central PMCID: PMC5871972.
  • Kirpich I, McClain C. More Alcohol, More Liver Injury: Not Always True. Alcohol Alcohol. 2017 Nov 1;52(6):627-628. doi: 10.1093/alcalc/agx064. PubMed PMID: 29036522.
  • Warner DR, Liu H, Miller ME, Ramsden CE, Gao B, Feldstein AE, Schuster S, McClain CJ, Kirpich IA. Dietary Linoleic Acid and Its Oxidized Metabolites Exacerbate Liver Injury Caused by Ethanol via Induction of Hepatic Proinflammatory Response in Mice. Am J Pathol. 2017 Oct;187(10):2232-2245. doi: 10.1016/j.ajpath.2017.06.008. PubMed PMID: 28923202; PubMed Central PMCID: PMC5808136.
  • Kirpich IA, McClain CJ, Vatsalya V, Schwandt M, Phillips M, Falkner KC, Zhang L, Harwell C, George DT, Umhau JC. Liver Injury and Endotoxemia in Male and Female Alcohol-Dependent Individuals Admitted to an Alcohol Treatment Program. Alcohol Clin Exp Res. 2017 Apr;41(4):747-757. doi: 10.1111/acer.13346. Epub 2017 Mar 2. PubMed PMID: 28166367; PubMed Central PMCID: PMC5378598.
  • Neuman MG, French SW, Zakhari S, Malnick S, Seitz HK, Cohen LB, Salaspuro M, Voinea-Griffin A, Barasch A, Kirpich IA, Thomes PG, Schrum LW, Donohue TM Jr, Kharbanda KK, Cruz M, Opris M. Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage. Exp Mol Pathol. 2017 Feb;102(1):162-180. doi: 10.1016/j.yexmp.2017.01.003. Epub 2017 Jan 7. Review. PubMed PMID: 28077318.
  • Barve S, Chen SY, Kirpich I, Watson WH, Mcclain C. Development, Prevention, and Treatment of Alcohol-Induced Organ Injury: The Role of Nutrition. Alcohol Res. 2017;38(2):289-302. Review. PubMed PMID: 28988580; PubMed Central PMCID: PMC5513692.
  • Osna NA, Carter WG, Ganesan M, Kirpich IA, McClain CJ, Petersen DR, Shearn CT, Tomasi ML, Kharbanda KK. Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World J Gastroenterol. 2016 Jul 21;22(27):6192-200. doi: 10.3748/wjg.v22.i27.6192. Review. PubMed PMID: 27468209; PubMed Central PMCID: PMC4945978.
  • Kirpich IA, Petrosino J, Ajami N, Feng W, Wang Y, Liu Y, Beier JI, Barve SS, Yin X, Wei X, Zhang X, McClain CJ. Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease. Am J Pathol. 2016 Apr;186(4):765-76. doi: 10.1016/j.ajpath.2015.11.017. PubMed PMID: 27012191; PubMed Central PMCID: PMC5808146.
  • Kirpich IA, Miller ME, Cave MC, Joshi-Barve S, McClain CJ. Alcoholic Liver Disease: Update on the Role of Dietary Fat. Biomolecules. 2016 Jan 6;6(1):1. doi: 10.3390/biom6010001. Review. PubMed PMID: 26751488; PubMed Central PMCID: PMC4808795.