Kirpich, Irina

Kirpich, Irina

Irina A. Kirpich, Ph.D.
Assistant Professor
Division of Gastroenterology, Hepatology and Nutrition
University of Louisville School of Medicine
Louisville, Kentucky 40202
502 852-1127
Photo - Irina Kirpich

Educational Background

  • B.Sc.: Lugansk State University (Lugansk, Ukraine)
  • M.Sc.: Lugansk State University (Lugansk, Ukraine)
  • Ph.D.: Pomor State University (Arkhangelsk, Russia)
  • D.Biol.Sc. Northern State University (Arkhangelsk, Russia)


Research Interests

  • Gut-Liver interactions in alcoholic and nonalcoholic liver disease
  • Alcohol and dietary fat mediated intestinal and liver injury
  • Gut barrier, microbiome, probiotics
  • Epigenetics and hepatic steatosis
  • Oxidized metabolites of linoleic acid (OXLAMs)

Recent Publications


  • I.Kirpich, J.Zhang, L.Gobejishvili, G.Kharebava, D.Barker, S.Ghare, S. Joshi Barve, C.J.McClain, S.Barve Ethanol induced hepatic steatosis involves epigenetic down regulation of CPT1α expression in mice. Alcoholism, Clinical and Experimental Research, 2013, Jul 26. doi: 10.1111/acer.12172. [Epub ahead of print]PMID: 23905631
  • I.Kirpich, W.Feng, Y.Wang, Y.Liu, J.Beier, G.Arteel, K.Falkner, S. Barve, C.J.McClain Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. Alcohol, 2013, May;47(3):257-64. PMID: 23453163
  • Y.Wang; Y.Liu; I.Kirpich; Z.Ma; C.Wang; M.Zhang; Jill Suttles; C.McClain, W.Feng Lactobacillus rhamnosus GG reduces hepatic TNF-alpha production and inflammation in chronic alcohol-induced liver injury. Journal of Nutritional Biochemistry, 2013 Apr 22. doi:pii: S0955-2863(13)00039-9. 10.1016/j.jnutbio.2013.02.001. [Epub ahead of print], PMID: 23618528; NIHMS510181
  • Bull-Otterson L, Feng W, Kirpich I, Wang Y, Qin X, Liu Y, Gobejishvili L, Joshi-Barve S, Ayvaz T, Petrosino J, Kong M, Barker D, McClain C, Barve S. Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment. PLoS One. 2013;8(1):e53028. PMID: 23326376; PMCID: PMC3541399
  • I.Kirpich, C.McClain Probiotics in the treatment of the liver diseases. Journal of American College of Nutrition. 2012, Feb;31(1):14-23. PMID: 22661622