Swati Joshi-Barve, Ph.D.

Swati Joshi-Barve

  • Associate Professor of Medicine

502-852-6991 - Academic Office


Education

  • B.Sc.: University of Poona (India)

  • M.Sc.: University of Poona (India)

  • Ph.D.: University of Kentucky

 

Research Interests

  • Mechanisms of alcoholic and nonalcoholic steatohepatitis, and hepatocellular carcinoma

  • Mechanisms of alcohol-induced immune dysfunction

  • Impact of acrolein and reactive aldehydes on liver disease


Featured Publications

  • Kirpich IA, Warner DR, Feng W, Joshi-Barve S, McClain CJ, Seth D, Zhong W, Zhou Z, Osna NA, Kharbanda KK. Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition: Summary of the ISBRA 2018 Symposium. Alcohol. 2019 May 23. pii: S0741-8329(19)30069-2. doi: 10.1016/j.alcohol.2019.05.004. [Epub ahead of print] Review. PubMed PMID: 31129175.
  • Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L. PDE4 Inhibition as a therapeutic target for alcoholic liver disease: from bedside to bench. Hepatology. 2019 May 13. doi: 10.1002/hep.30761. [Epub ahead of print] PubMed PMID: 31081957.
  • Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. PubMed PMID: 30557659; PubMed Central PMCID: PMC6445388.
  • Denny JE, Powers JB, Castro HF, Zhang J, Joshi-Barve S, Campagna SR, Schmidt NW. Differential Sensitivity to Plasmodium yoelii Infection in C57BL/6 Mice Impacts Gut-Liver Axis Homeostasis. Sci Rep. 2019 Mar 5;9(1):3472. doi: 10.1038/s41598-019-40266-6. PubMed PMID: 30837607; PubMed Central PMCID: PMC6401097.
  • Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115-G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. PubMed PMID: 30234998; PubMed Central PMCID: PMC6383378.
  • Moghe A, Barve SS, McClain CJ, Joshi-Barve S. Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV. Cell Mol Gastroenterol Hepatol. 2017 Dec 9;5(2):163-164. doi: 10.1016/j.jcmgh.2017.11.009. eCollection 2018. PubMed PMID: 29693044; PubMed Central PMCID: PMC5904047.
  • Chen WY, Wang M, Zhang J, Barve SS, McClain CJ, Joshi-Barve S. Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability. Am J Pathol. 2017 Dec;187(12):2686-2697. doi: 10.1016/j.ajpath.2017.08.015. Epub 2017 Sep 19. PubMed PMID: 28935573; PubMed Central PMCID: PMC5818631.
  • Beier JI, Guo L, Ritzenthaler JD, Joshi-Barve S, Roman J, Arteel GE. Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice. Ann Hepatol. 2016 Sep-Oct;15(5):762-72. doi: 10.5604/16652681.1212587. PubMed PMID: 27493116; PubMed Central PMCID: PMC5081273.
  • Ghare SS, Donde H, Chen WY, Barker DF, Gobejishvilli L, McClain CJ, Barve SS, Joshi-Barve S. Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26. PubMed PMID: 27238871; PubMed Central PMCID: PMC4938746.
  • Chen WY, Zhang J, Ghare S, Barve S, McClain C, Joshi-Barve S. Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. Cell Mol Gastroenterol Hepatol. 2016 May 27;2(5):685-700. doi: 10.1016/j.jcmgh.2016.05.010. eCollection 2016 Sep. PubMed PMID: 28119953; PubMed Central PMCID: PMC5042858.