Swati Joshi-Barve, Ph.D.

Associate Professor of Medicine

502-852-5244 E-mail

Education and Training

B.Sc.: University of Poona
M.Sc.: University of Poona
Ph.D.: University of Kentucky

Research Interests

  • Mechanisms of alcoholic and nonalcoholic steatohepatitis, and hepatocellular carcinoma
  • Mechanisms of alcohol-induced immune dysfunction
  • Impact of acrolein and reactive aldehydes on liver disease

Featured Publications

  • Kirpich IA, Warner DR, Feng W, Joshi-Barve S, McClain CJ, Seth D, Zhong W, Zhou Z, Osna NA, Kharbanda KK. Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium. Alcohol. 2020 Mar;83:105-114. doi: 10.1016/j.alcohol.2019.05.004. Epub 2019 May 23. Review. PubMed PMID: 31129175; PubMed Central PMCID: PMC7043088.
  • Wang M, Chen WY, Zhang J, Gobejishvili L, Barve SS, McClain CJ, Joshi-Barve S. Elevated fructose and uric acid via aldose reductase contribute to experimental and human alcoholic liver disease. Hepatology. 2020 Feb 22. doi: 10.1002/hep.31197. [Epub ahead of print] PubMed PMID: 32086945.
  • Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L. Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench. Hepatology. 2019 Dec;70(6):1958-1971. doi: 10.1002/hep.30761. Epub 2019 Jun 25. PubMed PMID: 31081957; PubMed Central PMCID: PMC6851418.
  • Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol. 2019 Oct 22;9(4):569-585. doi: 10.1016/j.jcmgh.2019.10.005. [Epub ahead of print] PubMed PMID: 31654770; PubMed Central PMCID: PMC7078548.
  • Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. PubMed PMID: 30557659; PubMed Central PMCID: PMC6445388.
  • Denny JE, Powers JB, Castro HF, Zhang J, Joshi-Barve S, Campagna SR, Schmidt NW. Differential Sensitivity to Plasmodium yoelii Infection in C57BL/6 Mice Impacts Gut-Liver Axis Homeostasis. Sci Rep. 2019 Mar 5;9(1):3472. doi: 10.1038/s41598-019-40266-6. PubMed PMID: 30837607; PubMed Central PMCID: PMC6401097.
  • Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115-G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. PubMed PMID: 30234998; PubMed Central PMCID: PMC6383378.
  • Moghe A, Barve SS, McClain CJ, Joshi-Barve S. Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV. Cell Mol Gastroenterol Hepatol. 2017 Dec 9;5(2):163-164. doi: 10.1016/j.jcmgh.2017.11.009. eCollection 2018. PubMed PMID: 29693044; PubMed Central PMCID: PMC5904047.
  • Chen WY, Wang M, Zhang J, Barve SS, McClain CJ, Joshi-Barve S. Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability. Am J Pathol. 2017 Dec;187(12):2686-2697. doi: 10.1016/j.ajpath.2017.08.015. Epub 2017 Sep 19. PubMed PMID: 28935573; PubMed Central PMCID: PMC5818631.
  • Beier JI, Guo L, Ritzenthaler JD, Joshi-Barve S, Roman J, Arteel GE. Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice. Ann Hepatol. 2016 Sep-Oct;15(5):762-72. doi: 10.5604/16652681.1212587. PubMed PMID: 27493116; PubMed Central PMCID: PMC5081273.