Swati Joshi-Barve, Ph.D.

Swati Joshi-Barve, Ph.D.

Swati Joshi-Barve

  • Associate Professor of Medicine

502-852-6991 - Academic Office


  • B.Sc.: University of Poona (India)

  • M.Sc.: University of Poona (India)

  • Ph.D.: University of Kentucky


Research Interests

  • Mechanisms of alcoholic and nonalcoholic steatohepatitis, and hepatocellular carcinoma

  • Mechanisms of alcohol-induced immune dysfunction

  • Impact of acrolein and reactive aldehydes on liver disease

Featured Publications

  • Moghe A, Barve SS, McClain CJ, Joshi-Barve S. Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV. Cell Mol Gastroenterol Hepatol. 2017 Dec 9;5(2):163-164. doi: 10.1016/j.jcmgh.2017.11.009. eCollection 2018. PubMed PMID: 29693044; PubMed Central PMCID: PMC5904047.
  • Chen WY, Wang M, Zhang J, Barve SS, McClain CJ, Joshi-Barve S. Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability. Am J Pathol. 2017 Dec;187(12):2686-2697. doi: 10.1016/j.ajpath.2017.08.015. Epub 2017 Sep 19. PubMed PMID: 28935573; PubMed Central PMCID: PMC5818631.
  • Beier JI, Guo L, Ritzenthaler JD, Joshi-Barve S, Roman J, Arteel GE. Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice. Ann Hepatol. 2016 Sep-Oct;15(5):762-72. doi: 10.5604/16652681.1212587. PubMed PMID: 27493116; PubMed Central PMCID: PMC5081273.
  • Ghare SS, Donde H, Chen WY, Barker DF, Gobejishvilli L, McClain CJ, Barve SS, Joshi-Barve S. Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26. PubMed PMID: 27238871; PubMed Central PMCID: PMC4938746.
  • Chen WY, Zhang J, Ghare S, Barve S, McClain C, Joshi-Barve S. Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. Cell Mol Gastroenterol Hepatol. 2016 May 27;2(5):685-700. doi: 10.1016/j.jcmgh.2016.05.010. eCollection 2016 Sep. PubMed PMID: 28119953; PubMed Central PMCID: PMC5042858.
  • Kirpich IA, Miller ME, Cave MC, Joshi-Barve S, McClain CJ. Alcoholic Liver Disease: Update on the Role of Dietary Fat. Biomolecules. 2016 Jan 6;6(1):1. doi: 10.3390/biom6010001. Review. PubMed PMID: 26751488; PubMed Central PMCID: PMC4808795.
  • Joshi-Barve S, Kirpich I, Cave MC, Marsano LS, McClain CJ. Alcoholic, Nonalcoholic, and Toxicant-Associated Steatohepatitis: Mechanistic Similarities and Differences. Cell Mol Gastroenterol Hepatol. 2015 Jun 3;1(4):356-367. doi: 10.1016/j.jcmgh.2015.05.006. eCollection 2015 Jul. Review. PubMed PMID: 28210688; PubMed Central PMCID: PMC5301292.
  • Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C, Joshi-Barve S. Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol Sci. 2015 Feb;143(2):242-55. doi: 10.1093/toxsci/kfu233. Review. PubMed PMID: 25628402; PubMed Central PMCID: PMC4306719.
  • Fernandez-Botran R, Joshi-Barve S, Ghare S, Barve S, Young M, Plankey M, Bordon J. Systemic cytokine and interferon responsiveness Patterns in HIV and HCV mono and co-infections. J Interferon Cytokine Res. 2014 Nov;34(11):885-93. doi: 10.1089/jir.2014.0006. Epub 2014 Jun 23. PubMed PMID: 24955730; PubMed Central PMCID: PMC4217006.
  • Ghare SS, Joshi-Barve S, Moghe A, Patil M, Barker DF, Gobejishvili L, Brock GN, Cave M, McClain CJ, Barve SS. Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells. J Immunol. 2014 Jul 1;193(1):412-21. doi: 10.4049/jimmunol.1400055. Epub 2014 Jun 4. PubMed PMID: 24899502; PubMed Central PMCID: PMC5096587.