Leila Gobejishvili, Ph.D.

Associate Professor of Medicine

502-852-0361 E-mail

Education and Training

B.Sc.: Tblisi State University
M.Sc.: Tblisi State University
Ph.D.: Institute of Physiology, Georgian Academy of Sciences

Research Interests

  • cAMP signaling in modulating systemic and hepatic inflammatory responses in alcoholic and non-alcoholic liver disease
  • Role of cAMP effector molecules in the activation of hepatic stellate cells and hepatic fibrosis
  • Therapeutic potential of phosphodiesterase 4 inhibitors for the treatment of alcoholic and non-alcoholic liver disease
  • Mechanisms of dysregulated cAMP homeostasis in hepatic parenchymal and non-parenchymal cells during liver injury

Featured Publications

  • Wang M, Chen WY, Zhang J, Gobejishvili L, Barve SS, McClain CJ, Joshi-Barve S. Elevated fructose and uric acid via aldose reductase contribute to experimental and human alcoholic liver disease. Hepatology. 2020 Feb 22. doi: 10.1002/hep.31197. [Epub ahead of print] PubMed PMID: 32086945.
  • Vatsalya V, Cave MC, Kong M, Gobejishvili L, Falkner KC, Craycroft J, Mitchell M, Szabo G, McCullough A, Dasarathy S, Radaeva S, Barton B, McClain CJ. Keratin 18 is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2019 Dec 4. pii: S1542-3565(19)31390-4. doi: 10.1016/j.cgh.2019.11.050. [Epub ahead of print] PubMed PMID: 31811953.
  • Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L. Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench. Hepatology. 2019 Dec;70(6):1958-1971. doi: 10.1002/hep.30761. Epub 2019 Jun 25. PubMed PMID: 31081957; PubMed Central PMCID: PMC6851418.
  • Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol. 2019 Oct 22;9(4):569-585. doi: 10.1016/j.jcmgh.2019.10.005. [Epub ahead of print] PubMed PMID: 31654770; PubMed Central PMCID: PMC7078548.
  • Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. PubMed PMID: 30557659; PubMed Central PMCID: PMC6445388.
  • Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115-G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. PubMed PMID: 30234998; PubMed Central PMCID: PMC6383378.
  • Zhou Y, Vatsalya V, Gobejishvili L, Lamont RJ, McClain CJ, Feng W. Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis. Hepatol Commun. 2018 Dec 14;3(2):293-304. doi: 10.1002/hep4.1296. eCollection 2019 Feb. PubMed PMID: 30766965; PubMed Central PMCID: PMC6357836.
  • Wahlang B, McClain C, Barve S, Gobejishvili L. Role of cAMP and phosphodiesterase signaling in liver health and disease. Cell Signal. 2018 Sep;49:105-115. doi: 10.1016/j.cellsig.2018.06.005. Epub 2018 Jun 11. Review. Erratum in: Cell Signal. 2019 Jan;53:414. PubMed PMID: 29902522; PubMed Central PMCID: PMC6445381.
  • Jones DZ, Schmidt ML, Suman S, Hobbing KR, Barve SS, Gobejishvili L, Brock G, Klinge CM, Rai SN, Park J, Clark GJ, Agarwal R, Kidd LR. Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells. BMC Cancer. 2018 Apr 13;18(1):421. doi: 10.1186/s12885-018-4258-0. PubMed PMID: 29653561; PubMed Central PMCID: PMC5899400.
  • Avila DV, Myers SA, Zhang J, Kharebava G, McClain CJ, Kim HY, Whittemore SR, Gobejishvili L, Barve S. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology. 2017 Oct;125:376-385. doi: 10.1016/j.neuropharm.2017.08.011. Epub 2017 Aug 12. PubMed PMID: 28807677; PubMed Central PMCID: PMC5797427.