Leila Gobejishvili, Ph.D.

Leila Gobejishvili

Leila Gobejishvili, Ph.D.

  • Associate Professor of Medicine

502-852-6911 - Academic Office


Education

  • B.Sc.: Tblisi State University (Republic of Georgia)

  • M.Sc.: Tblisi State University (Republic of Georgia)

  • Ph.D.: Institute of Physiology, Georgian Academy of Sciences (Republic of Georgia)

 

Research Interests

  • Alcohol induced changes in innate immunity

  • Alcohol mediated epigenetic changes of pro-inflammatory cytokines

  • Role of phosphodiesterases in priming of monocytes and development of liver injury/fibrosis


Featured Publications

  • Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L. PDE4 Inhibition as a therapeutic target for alcoholic liver disease: from bedside to bench. Hepatology. 2019 May 13. doi: 10.1002/hep.30761. [Epub ahead of print] PubMed PMID: 31081957.
  • Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. PubMed PMID: 30557659; PubMed Central PMCID: PMC6445388.
  • Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115-G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. PubMed PMID: 30234998; PubMed Central PMCID: PMC6383378.
  • Zhou Y, Vatsalya V, Gobejishvili L, Lamont RJ, McClain CJ, Feng W. Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis. Hepatol Commun. 2018 Dec 14;3(2):293-304. doi: 10.1002/hep4.1296. eCollection 2019 Feb. PubMed PMID: 30766965; PubMed Central PMCID: PMC6357836.
  • Wahlang B, McClain C, Barve S, Gobejishvili L. Role of cAMP and phosphodiesterase signaling in liver health and disease. Cell Signal. 2018 Sep;49:105-115. doi: 10.1016/j.cellsig.2018.06.005. Epub 2018 Jun 11. Erratum in: Cell Signal. 2019 Jan;53:414. PubMed PMID: 29902522; PubMed Central PMCID: PMC6445381.
  • Jones DZ, Schmidt ML, Suman S, Hobbing KR, Barve SS, Gobejishvili L, Brock G, Klinge CM, Rai SN, Park J, Clark GJ, Agarwal R, Kidd LR. Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells. BMC Cancer. 2018 Apr 13;18(1):421. doi: 10.1186/s12885-018-4258-0. PubMed PMID: 29653561; PubMed Central PMCID: PMC5899400.
  • Avila DV, Myers SA, Zhang J, Kharebava G, McClain CJ, Kim HY, Whittemore SR, Gobejishvili L, Barve S. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology. 2017 Oct;125:376-385. doi: 10.1016/j.neuropharm.2017.08.011. Epub 2017 Aug 12. PubMed PMID: 28807677; PubMed Central PMCID: PMC5797427.
  • Avila DV, Barker DF, Zhang J, McClain CJ, Barve S, Gobejishvili L. Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis. J Pathol. 2016 Sep;240(1):96-107. doi: 10.1002/path.4760. PubMed PMID: 27287961; PubMed Central PMCID: PMC4993672.
  • Vatsalya V, Avila D, Frimodig JC, Barve SS, McClain CJ, Gobejishvili L. Liver Injury Assessment by Vetscan VS2 Analyzer and Most Frequently Used ALT/GTP Reagent. Gastroenterol Hepatol (Bartlesville). 2016;4(4). pii: 107. Epub 2016 Apr 13. PubMed PMID: 27275009; PubMed Central PMCID: PMC4890971.
  • Gobejishvili L, Ghare S, Khan R, Cambon A, Barker DF, Barve S, McClain C, Hill D. Misoprostol modulates cytokine expression through a cAMP pathway: Potential therapeutic implication for liver disease. Clin Immunol. 2015 Dec;161(2):291-9. doi: 10.1016/j.clim.2015.09.008. Epub 2015 Sep 25. PubMed PMID: 26408955; PubMed Central PMCID: PMC4658275.