Wenke Feng, Ph.D.

Wenke Feng, M.D.

  • Associate Professor of Medicine

502-852-6991 - Academic Office


  • B.Sc.: Shaanxi Normal University (Xi'an, China)
  • M.Sc.: Northwest University (Xi'an, China)
  • Ph.D.: University of Natural Resources and Life Sciences (Vienna, Austria)


Research Interests

  • Mechanisms of Alcoholic Liver Disease
  • Mechanisms of Non-alcoholic Steatohepatitis
  • Tissue Hypoxia and Diabetic Complications


Featured Publications

  • He L, Li F, Yin X, Bohman P, Kim S, McClain CJ, Feng W, Zhang X. Profiling of Polar Metabolites in Mouse Feces Using Four Analytical Platforms to Study the Effects Of Cathelicidin-Related Antimicrobial Peptide in Alcoholic Liver Disease. J Proteome Res. 2019 Jun 12. doi: 10.1021/acs.jproteome.9b00181. [Epub ahead of print] PubMed PMID: 31188604.
  • Kong X, Wu G, Chen S, Zhang L, Li F, Shao T, Ren L, Chen S, Zhang H, McClain CJ, Feng W. Chalcone Derivative L6H21 Reduces EtOH+LPS-induced Liver Injury through Inhibition of NLRP3 Inflammasome Activation. Alcohol Clin Exp Res. 2019 Jun 4. doi: 10.1111/acer.14120. [Epub ahead of print] PubMed PMID: 31162673.
  • Kirpich IA, Warner DR, Feng W, Joshi-Barve S, McClain CJ, Seth D, Zhong W, Zhou Z, Osna NA, Kharbanda KK. Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition: Summary of the ISBRA 2018 Symposium. Alcohol. 2019 May 23. pii: S0741-8329(19)30069-2. doi: 10.1016/j.alcohol.2019.05.004. [Epub ahead of print] Review. PubMed PMID: 31129175.
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey DW, Merchant ML, Watson CT, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis. J Proteome Res. 2019 Apr 5;18(4):1582-1594. doi: 10.1021/acs.jproteome.8b00886. Epub 2019 Mar 15. PubMed PMID: 30807179.
  • Fang P, Xiang L, Chen W, Li S, Huang S, Li J, Zhuge L, Jin L, Feng W, Chen Y, Pan C. LncRNA GAS5 enhanced the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3. Innate Immun. 2019 Feb;25(2):99-109. doi: 10.1177/1753425919827632. PubMed PMID: 30774011.
  • Zhou Y, Vatsalya V, Gobejishvili L, Lamont RJ, McClain CJ, Feng W. Porphyromonas gingivalis as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis. Hepatol Commun. 2018 Dec 14;3(2):293-304. doi: 10.1002/hep4.1296. eCollection 2019 Feb. PubMed PMID: 30766965; PubMed Central PMCID: PMC6357836.
  • Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W. Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction. J Hepatol. 2018 Oct;69(4):886-895. doi: 10.1016/j.jhep.2018.05.021. Epub 2018 May 25. PubMed PMID: 29803899.
  • He L, Prodhan MAI, Yuan F, Yin X, Lorkiewicz PK, Wei X, Feng W, McClain C, Zhang X. Simultaneous quantification of straight-chain and branched-chain short chain fatty acids by gas chromatography mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:359-367. doi: 10.1016/j.jchromb.2018.06.028. Epub 2018 Jun 18. PubMed PMID: 29936372; PubMed Central PMCID: PMC6190712.
  • Wu G, Liu Y, Liu Y, Zhang L, Zhao H, Liu L, Zhao C, Feng W. FGF 21 deficiency slows gastric emptying and reduces initial blood alcohol concentration in mice exposed to acute alcohol in fasting state. Biochem Biophys Res Commun. 2018 Feb 26;497(1):46-50. doi: 10.1016/j.bbrc.2018.01.189. Epub 2018 Feb 12. PubMed PMID: 29448103; PubMed Central PMCID: PMC6044432.
  • Yuan F, Chen X, Liu J, Feng W, Cai L, Wu X, Chen SY. Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos. Exp Neurol. 2018 Feb;300:60-66. doi: 10.1016/j.expneurol.2017.10.020. Epub 2017 Oct 22. PubMed PMID: 29069573; PubMed Central PMCID: PMC5745274.