Wenke Feng, Ph.D.

Professor of Medicine


502-852-2912 E-mail

Education and Training

B.Sc.: Shaanxi Normal University (Xi'an, China)
M.Sc.: Northwest University (Xi'an, China)
Ph.D.: University of Natural Resources and Life Sciences (Vienna, Austria)


Research Interests

    • Mechanisms of Alcoholic Liver Disease
    • Mechanisms of Non-alcoholic Steatohepatitis
    • Tissue Hypoxia and Diabetic Complications

Featured Publications

    • Kirpich IA, Warner DR, Feng W, Joshi-Barve S, McClain CJ, Seth D, Zhong W, Zhou Z, Osna NA, Kharbanda KK. Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium. Alcohol. 2020 Mar;83:105-114. doi: 10.1016/j.alcohol.2019.05.004. Epub 2019 May 23. Review. PubMed PMID: 31129175; PubMed Central PMCID: PMC7043088.
    • Xu H, Wang X, Feng W, Liu Q, Zhou S, Liu Q, Cai L. The gut microbiota and its interactions with cardiovascular disease. Microb Biotechnol. 2020 Jan 26. doi: 10.1111/1751-7915.13524. [Epub ahead of print] Review. PubMed PMID: 31984651.
    • Liu Q, Liu Y, Li F, Gu Z, Liu M, Shao T, Zhang L, Zhou G, Pan C, He L, Cai J, Zhang X, Barve S, McClain CJ, Chen Y, Feng W. Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. J Nutr Biochem. 2020 Jan;75:108256. doi: 10.1016/j.jnutbio.2019.108256. Epub 2019 Oct 24. PubMed PMID: 31760308.
    • Ren L, Song Q, Liu Y, Zhang L, Hao Z, Feng W. Probiotic Lactobacillus rhamnosus GG prevents progesterone metabolite epiallaopregnanolone sulfate-induced hepatic bile acid accumulation and liver injury. Biochem Biophys Res Commun. 2019 Nov 26;520(1):67-72. doi: 10.1016/j.bbrc.2019.09.103. Epub 2019 Sep 28. PubMed PMID: 31575408; PubMed Central PMCID: PMC6876860.
    • Zhao C, Liu L, Liu Q, Li F, Zhang L, Zhu F, Shao T, Barve S, Chen Y, Li X, McClain CJ, Feng W. Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice. Mol Metab. 2019 Nov;29:145-157. doi: 10.1016/j.molmet.2019.08.020. Epub 2019 Sep 3. PubMed PMID: 31668386; PubMed Central PMCID: PMC6812038.
    • Li Y, Yuan F, Wu T, Lu L, Liu J, Feng W, Chen SY. Sulforaphane protects against ethanol-induced apoptosis in neural crest cells through restoring epithelial-mesenchymal transition by epigenetically modulating the expression of Snail1. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2586-2594. doi: 10.1016/j.bbadis.2019.07.002. Epub 2019 Jul 8. PubMed PMID: 31295528; PubMed Central PMCID: PMC6708741.
    • Fan H, Yuan F, Yun Y, Wu T, Lu L, Liu J, Feng W, Chen SY. MicroRNA-34a mediates ethanol-induced impairment of neural differentiation of neural crest cells by targeting autophagy-related gene 9a. Exp Neurol. 2019 Oct;320:112981. doi: 10.1016/j.expneurol.2019.112981. Epub 2019 Jun 24. PubMed PMID: 31247197; PubMed Central PMCID: PMC6708457.
    • Liu Y, Chen K, Li F, Gu Z, Liu Q, He L, Shao T, Song Q, Zhu F, Zhang L, Jiang M, Zhou Y, Barve S, Zhang X, McClain CJ, Feng W. Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice. Hepatology. 2019 Sep 30. doi: 10.1002/hep.30975. [Epub ahead of print] PubMed PMID: 31571251.
    • Xu H, Wang J, Cai J, Feng W, Wang Y, Liu Q, Cai L. Protective Effect of Lactobacillus rhamnosus GG and its Supernatant against Myocardial Dysfunction in Obese Mice Exposed to Intermittent Hypoxia is Associated with the Activation of Nrf2 Pathway. Int J Biol Sci. 2019 Sep 7;15(11):2471-2483. doi: 10.7150/ijbs.36465. eCollection 2019. PubMed PMID: 31595164; PubMed Central PMCID: PMC6775312.
    • Kong X, Wu G, Chen S, Zhang L, Li F, Shao T, Ren L, Chen SY, Zhang H, McClain CJ, Feng W. Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation. Alcohol Clin Exp Res. 2019 Aug;43(8):1662-1671. doi: 10.1111/acer.14120. Epub 2019 Jun 30. PubMed PMID: 31162673; PubMed Central PMCID: PMC6790986.