Craig McClain

Craig McClain

Craig J. McClain, M.D.

Craig J. McClain, M.D.

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Translational Research
  • Associate Vice President for Health Affairs/Research
  • Associate Director, Fellowship Training Program
  • Distinguished University Scholar
  • Chief GI - Robley Rex VAMC
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments

Clinical Expertise

General Hepatology, Transplant Hepatology, Nutrition, Alcoholic Liver Disease, Non-Alcoholic Steatohepatitis

Board Certifications

  • American Board of Internal Medicine - Internal Medicine / Gastroenterology

  • Certification Board for Nutrition Specialists

  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee

  • Residency: University of Pittsburgh Hospitals

  • Fellowship: University of Minnesota Hospitals

Recent Publications

    1.         Bull-Otterson L, Feng W, Kirpich I, Wang Y, Qin X, Liu Y, Gobejishvili L, Joshi-Barve S, Ayvaz T, Petrosino J, Kong M, Barker D, McClain C, Barve S.  Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosis GG treatment.  PLOS One, 2013, 8(1):e53028. doi:10.1371/journal.pone.0053028. PMID: 23326376; PMCID: PMC3541399


    2.          Kirpich I, Feng W, Wang Y, Liu Y, Beier JI, Arteel GE, Falkner KC, Barve SS, McClain CJ.  Ethanol and Dietary Unsaturated Fat (Corn Oil/Linoleic Acid Enriched) Cause Intestinal Inflammation and Impaired Intestinal Barrier Defense in Mice Chronically Fed Alcohol. Alcohol 2013 May;47(3):257-64. Doi:10.1016/j.alcohol.2013.01.005. E-pub 2013 Feb 26.  PMID: 23665587; PMCID:PMC3617059


    3.          Song M, Schuschke DA, Zhou Z, Chen T, Shi X, Zhang J, Zhang X, Pierce WM Jr, Johnson WT, McClain CJ. Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats.  Obesity (Silver Spring) 2013 Mar 20 doi:10.1002/oby.2038 [E-pub ahead of print]  PMID: 23512597; PMCID: PMC3695073


    4.         Carithers RL Jr, McClain C: Alcoholic liver disease. In: Feldman M, Friedman LS, Sleisenger MH, eds.  In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 2016. 11th Edition, 2015, Philadelphia: Saunders Elsevier


    5.         Kirpich IA, Marsano L, McClain CJ. Gut-Liver Axis, Nutrition, and Non Alcoholic Fatty Liver Disease.  Clin Biochem. 2015 Jul 4. pii: S0009-9120(15)00261-1. doi: 10.1016/j.clinbiochem.2015.06.023. [Epub ahead of print. PMID: 26151226


    Underlined is a trainee