Craig McClain

Craig McClain


Craig J. McClain, M.D.






Craig J. McClain, M.D.

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Translational Research
  • Associate Director, Fellowship Training Program
  • Distinguished University Scholar
  • Chief GI - Robley Rex VAMC
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-813-6500 - Patient Appointments


Clinical Expertise

General Hepatology, Transplant Hepatology, Nutrition, Alcoholic Liver Disease, Non-Alcoholic Steatohepatitis


Board Certifications

  • American Board of Internal Medicine - Internal Medicine / Gastroenterology

  • Certification Board for Nutrition Specialists

  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee

  • Residency: University of Pittsburgh Hospitals

  • Fellowship: University of Minnesota Hospitals


Recent Publications

  • McClain CJ, Cohen DA: Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9:349-351, 1989. Second most cited liver pathobiology article in Hepatology. PMID: 2920991.
  • McClain CJ, Hill DB, Marsano L. Nutrition Liver Disease, Present Knowledge in Nutrition, Erdman JW, Macdonald IA, Zeisel SH (eds) Vol 2. (International Life Sciences Institute, Washington, DC) 2012. 10th Ed. Chapter 54, pp 889-911.
  • Bull-Otterson L, Feng W, Kirpich I, Wang Y, Qin X, Liu Y, Gobejishvili L, Joshi-Barve S, Ayvaz T, Petrosino J, McClain C, Barve S. Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosis GG treatment. PLOS One, 2013, 8(1):e53028. doi:10.1371/journal.pone.0053028. PMID: 23326376; PMCID: PMC3541399
  • Song M, Schuschke DA, Zhou Z, Chen T, Shi X, Zhang J, Zhang X, Pierce WM Jr, Johnson WT, McClain CJ. Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats. Obesity (Silver Spring) 2013 Mar 20 doi:10.1002/oby.2038 [E-pub ahead of print] PMID: 23512597
  • Gobejishvili L, Barve S, Breitkopf-Heinlein K, Li Y, Zhang J, Avila D, Dooley S, McClain, CJ. Development of liver inflammation and fibrosis is critically regulated by phosphodiesterase 4 sub-family. J Pharmacol Exp Ther 2013 Jul 25 [Epub ahead of print]. PMID: 23887098