Craig McClain

Craig McClain

Craig J. McClain, M.D.

Craig J. McClain, M.D.

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Translational Research
  • Associate Vice President for Health Affairs/Research
  • Associate Director, Fellowship Training Program
  • Distinguished University Scholar
  • Chief GI - Robley Rex VAMC
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments

Clinical Expertise

General Hepatology, Transplant Hepatology, Nutrition, Alcoholic Liver Disease, Non-Alcoholic Steatohepatitis

Board Certifications

  • American Board of Internal Medicine - Internal Medicine / Gastroenterology

  • Certification Board for Nutrition Specialists

  • American Board of Physician Nutrition Specialists




Education and Training

  • Medical School: University of Tennessee

  • Residency: University of Pittsburgh Hospitals

  • Fellowship: University of Minnesota Hospitals

Recent Publications

    1.        Kirpich IA, Petrosino J, Ajami N, Feng W, Wang Y, Liu Y, Beier JI, Barve SS, Yin X, Wei X, Zhang X, McClain CJ.  Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease.  Am J Pathol. 2016; 85(4):765–776. PMID:  27012191; DOI: 10.1016/j.ajpath.2015.11.017  


    2.          Mitchell MC, Friedman LS, McClain CJ. Medical Management of Severe Alcoholic Hepatitis: Expert Review from the Clinical Practice Updates Committee of the AGA Institute.  Clinical Gastroenterology and Hepatology. 2017 Jan;15(1):5-12. Doi:10.1016/j.cgh.2016.08.047. PMID: 27979049; PMCID: PMC5172399; DOI: 10.1016/j.cgh.2016.08.047


    3.        Carithers RL Jr, McClain C: Alcoholic liver disease. In: Feldman M, Sleisenger MH, Friedman LS, eds.  In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 2016. Vol 2, Chapter 86, p 1409-1427, 11th Edition, 2016, Philadelphia: Saunders Elsevier.


    4.        Barve S, Chen S-Y, Kirpich I, Watson WH, McClain CJ. Development and Prevention/Treatment of Alcohol-Induced Organ Injury: The Role of Nutrition. Alcohol Research: Current Reviews 2017 38(2):289-302. PMID:  28988580; PMCID:  PMC5513692


    5.       McClain CJ,Kirpich IA, Smart L.  Malnutrition and Liver Diseases. Chapter 19, In: Schiff’s Diseases of the Liver, 12th Edition. Schiff ER, Maddrey WC, Sorrell MF, Eds. 2017 Schiff's Diseases of the Liver, 12th Edition.  Wiley, 2017. ISBN: 978-1-119-25122-4



    Underlined investigator is a resident, fellow, graduate student or NIH mentored faculty in Dr. McClain’s laboratory.