Shirish S. Barve, Ph.D.

Shirish S. Barve, Ph.D.

  • Professor of Medicine
  • Distinguished University Scholar

502-852-6991 - Academic Office


Education

  • B.Sc.: University of Bombay

  • M.Sc.: University of Bombay

  • Ph.D.: University of Kentucky

 

Featured Publications

  • Chichetto NE, Kundu S, Freiberg MS, Butt AA, Crystal S, So-Armah KA, Cook RL, Braithwaite RS, Fiellin DA, Khan MR, Bryant KJ, Gaither JR, Barve SS, Crothers K, Bedimo RJ, Warner AL, Tindle HA; Veterans Aging Cohort Study. Association of Syndemic Unhealthy Alcohol Use, Cigarette Use, and Depression With All-Cause Mortality Among Adults Living With and Without HIV Infection: Veterans Aging Cohort Study. Open Forum Infect Dis. 2019 May 16;6(6):ofz188. doi: 10.1093/ofid/ofz188. eCollection 2019 Jun. PubMed PMID: 31211153; PubMed Central PMCID: PMC6559272.
  • Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L. PDE4 Inhibition as a therapeutic target for alcoholic liver disease: from bedside to bench. Hepatology. 2019 May 13. doi: 10.1002/hep.30761. [Epub ahead of print] PubMed PMID: 31081957.
  • Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. PubMed PMID: 30557659; PubMed Central PMCID: PMC6445388.
  • Vatsalya V, Cave MC, Kumar R, Srivastava S, Khanal S, Jenson AB, Schwandt ML, Barve SS, Ramchandani VA, McClain CJ. Alterations in Serum Zinc and Polyunsaturated Fatty Acid Concentrations in Treatment-Naive HIV-Diagnosed Alcohol-Dependent Subjects with Liver Injury. AIDS Res Hum Retroviruses. 2019 Jan;35(1):92-99. doi: 10.1089/AID.2018.0124. Epub 2018 Dec 11. PubMed PMID: 30280905; PubMed Central PMCID: PMC6343188.
  • Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115-G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. PubMed PMID: 30234998; PubMed Central PMCID: PMC6383378.
  • Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W. Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction. J Hepatol. 2018 Oct;69(4):886-895. doi: 10.1016/j.jhep.2018.05.021. Epub 2018 May 25. PubMed PMID: 29803899.
  • Wahlang B, McClain C, Barve S, Gobejishvili L. Role of cAMP and phosphodiesterase signaling in liver health and disease. Cell Signal. 2018 Sep;49:105-115. doi: 10.1016/j.cellsig.2018.06.005. Epub 2018 Jun 11. Erratum in: Cell Signal. 2019 Jan;53:414. PubMed PMID: 29902522; PubMed Central PMCID: PMC6445381.
  • Jones DZ, Schmidt ML, Suman S, Hobbing KR, Barve SS, Gobejishvili L, Brock G, Klinge CM, Rai SN, Park J, Clark GJ, Agarwal R, Kidd LR. Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells. BMC Cancer. 2018 Apr 13;18(1):421. doi: 10.1186/s12885-018-4258-0. PubMed PMID: 29653561; PubMed Central PMCID: PMC5899400.
  • Moghe A, Barve SS, McClain CJ, Joshi-Barve S. Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV. Cell Mol Gastroenterol Hepatol. 2017 Dec 9;5(2):163-164. doi: 10.1016/j.jcmgh.2017.11.009. eCollection 2018. PubMed PMID: 29693044; PubMed Central PMCID: PMC5904047.
  • Chen WY, Wang M, Zhang J, Barve SS, McClain CJ, Joshi-Barve S. Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability. Am J Pathol. 2017 Dec;187(12):2686-2697. doi: 10.1016/j.ajpath.2017.08.015. Epub 2017 Sep 19. PubMed PMID: 28935573; PubMed Central PMCID: PMC5818631.