Shirish S. Barve, Ph.D.

Professor of Medicine
Distinguished University Scholar


502-852-5245 E-mail

Education and Training

B.Sc.: University of Bombay
M.Sc.: University of Bombay
Ph.D.: University of Kentucky


Featured Publications

  • Wang M, Chen WY, Zhang J, Gobejishvili L, Barve SS, McClain CJ, Joshi-Barve S. Elevated fructose and uric acid via aldose reductase contribute to experimental and human alcoholic liver disease. Hepatology. 2020 Feb 22. doi: 10.1002/hep.31197. [Epub ahead of print] PubMed PMID: 32086945.
  • Liu Q, Liu Y, Li F, Gu Z, Liu M, Shao T, Zhang L, Zhou G, Pan C, He L, Cai J, Zhang X, Barve S, McClain CJ, Chen Y, Feng W. Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. J Nutr Biochem. 2020 Jan;75:108256. doi: 10.1016/j.jnutbio.2019.108256. Epub 2019 Oct 24. PubMed PMID: 31760308.
  • Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L. Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench. Hepatology. 2019 Dec;70(6):1958-1971. doi: 10.1002/hep.30761. Epub 2019 Jun 25. PubMed PMID: 31081957; PubMed Central PMCID: PMC6851418.
  • Zhao C, Liu L, Liu Q, Li F, Zhang L, Zhu F, Shao T, Barve S, Chen Y, Li X, McClain CJ, Feng W. Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice. Mol Metab. 2019 Nov;29:145-157. doi: 10.1016/j.molmet.2019.08.020. Epub 2019 Sep 3. PubMed PMID: 31668386; PubMed Central PMCID: PMC6812038.
  • Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol. 2019 Oct 22;9(4):569-585. doi: 10.1016/j.jcmgh.2019.10.005. [Epub ahead of print] PubMed PMID: 31654770; PubMed Central PMCID: PMC7078548.
  • Liu Y, Chen K, Li F, Gu Z, Liu Q, He L, Shao T, Song Q, Zhu F, Zhang L, Jiang M, Zhou Y, Barve S, Zhang X, McClain CJ, Feng W. Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice. Hepatology. 2019 Sep 30. doi: 10.1002/hep.30975. [Epub ahead of print] PubMed PMID: 31571251.
  • Chichetto NE, Kundu S, Freiberg MS, Butt AA, Crystal S, So-Armah KA, Cook RL, Braithwaite RS, Fiellin DA, Khan MR, Bryant KJ, Gaither JR, Barve SS, Crothers K, Bedimo RJ, Warner AL, Tindle HA; Veterans Aging Cohort Study. Association of Syndemic Unhealthy Alcohol Use, Cigarette Use, and Depression With All-Cause Mortality Among Adults Living With and Without HIV Infection: Veterans Aging Cohort Study. Open Forum Infect Dis. 2019 May 16;6(6):ofz188. doi: 10.1093/ofid/ofz188. eCollection 2019 Jun. PubMed PMID: 31211153; PubMed Central PMCID: PMC6559272.
  • Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Neurobiol Dis. 2019 Apr;124:353-363. doi: 10.1016/j.nbd.2018.12.008. Epub 2018 Dec 14. PubMed PMID: 30557659; PubMed Central PMCID: PMC6445388.
  • Vatsalya V, Cave MC, Kumar R, Srivastava S, Khanal S, Jenson AB, Schwandt ML, Barve SS, Ramchandani VA, McClain CJ. Alterations in Serum Zinc and Polyunsaturated Fatty Acid Concentrations in Treatment-Naive HIV-Diagnosed Alcohol-Dependent Subjects with Liver Injury. AIDS Res Hum Retroviruses. 2019 Jan;35(1):92-99. doi: 10.1089/AID.2018.0124. Epub 2018 Dec 11. PubMed PMID: 30280905; PubMed Central PMCID: PMC6343188.
  • Vatsalya V, Kong M, Gobejishvili L, Chen WY, Srivastava S, Barve S, McClain C, Joshi-Barve S. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G115-G122. doi: 10.1152/ajpgi.00209.2018. Epub 2018 Sep 20. PubMed PMID: 30234998; PubMed Central PMCID: PMC6383378.