Research Activities

Research Activities

endo-labThe focus of our research programs is on insulin signaling mechanisms, islet cell transplantation, gonadotropin gene expression, endocrine oncology, male hypogonadism, and clinical diabetes.

  • Sathya Krishnasamy, M.D. - "I am interested in clinical research in patients with the metabolic syndrome. I am currently investigating the impact of Vitamin D deficiency in obesity and cardiovascular function."
  • SriPrakash Mokshagundam, M.D. - "I am interested in clinical research in type 2 diabetes. I am presently studying glucose intolerance in patients with spinal cord injury and mechanisms of inflammation in diabetes mellitus."
  • Joseph P. Moore, Ph.D. and Stephen J. Winters, M.D. - "Our research examines the regulation of follistatin and gonadotropin subunit gene expression by pituitary adenylate cyclase-activating polypeptide (PACAP) in the fetal and newborn pituitary. This peptide differentially regulates expression of the gonadotropins LH and FSH through a novel paracrine mechanism applicable primarily in the fetus."

  • Betty C. Villafuerte, M.D. - "My laboratory studies insulin-regulated gene transcription in type 2 diabetes. We identified a novel Akt substrate that we named IRE-BP1 which binds to the insulin-response elements of insulin-like growth factor binding protein-3 and other insulin-responsive genes. We are presently examining the regulation of IRE-BP1 by insulin and its function in rat models of diabetes. We are also studying the effects of IRE-BP1 over-expression in pancreatic beta cells in the regulation of insulin secretion, and in the control of body weight and appetite."
  • Sham K. Kakar, Ph.D. - "My major research interest is to understand the molecular mechanism for the causation and prevention of hormone-related cancers. I am working on two research projects: 1) to define the molecular mechanisms for inhibition of tumor cell growth and proliferation by gonadotropin-releasing hormone receptor activation, and 2) to study the role of pituitary tumor transforming gene (PTTG) in the development of ovarian tumorigenesis and matastasis."