Dr. Srivastava has a Ph.D. from Lucknow University, Lucknow, India. He is working to delineate the mechanisms by which oxidized lipids and environmental pollutants that induce oxidative stress, such as arsenic, induce/propagate atherogenesis (supported by NIH projects R01 projects and ES17260 and HL-95593). Ongoing studies in his laboratory suggest aldehydes generated by oxidative stress crosslink with the protein in the endoplasmic reticulm (ER). The aldehyde-modified proteins are not folded properly and accumulate in the ER, leading to ER-stress, which in turn exacerbates vascular inflammation and atherogenesis.
Dr. Srivastava serves as an ad-hoc reviewer on several NIH study sections, including Atherosclerosis and Inflammation in Cardiovascular Systems, Vascular Cell and Molecular Biology, and Clinical and Integrated Cardiovascular Sciences.
Dr. Srivastava was inducted as a Fellow of American Heart Association in 2010. He also serves on the editorial board of Circulation Research.
- Srivastava S., Vladykovskaya E., Barski O.A., Spite M., Kaiserova K., Petrash J.M., Chung S.S., Hunt G., Dawn B., and Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ. Res. 105:793-802, 2009.
- Baba S.P., Barski O.A., Ahmed Y., O’Toole T.E., Conklin D.J., Bhatnagar A. and Srivastava S. Role of aldose reductase in the metabolism of the precursors of advanced glycation end products. Diabetes 58:2486-97, 2009
- Srivastava S, Sithu SD, D'Souza SE, Vladykovskaya E, Haberzettl P, Hoetker DJ, Siddiqui MA, Conklin DJ, and Aruni Bhatnagar. Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice. Atherosclerosis 215: 301-308, 2011.