Education and Training

M.D.: Beijing University of Chinese Medicine
Ph.D.: Beijing University of Chinese Medicine
Postdoctoral Fellowship: University of Louisville, Cardiology

Research Interests

Dr. Nong leads the Surgery and Cardiac Function Core in the Center for Cardiometabolic Science. The mission of the Core is to develop and implement in vivo models to support the needs of investigators in the Center, as well as others on campus. We perform a growing list of surgeries and cardiac function measurements on small animals.

Animal Models

• Myocardial infarction (MI) with/without reperfusion
• Transverse aortic constriction (TAC)
• Apical resection on neonatal mouse
• Intracardiac and intraventricular administrations of test substances/cells/virus (Echo-guided/Open-chest)
• Vascular anastomosis
• Splenic transplantation
• ECG/EEG/EMG telemetry implants

We also provide consultation on new animal model development.

Cardiac Function Measurements

• Conventional echocardiography: M-mode, B-mode, Doppler and strain analysis
• 3D and 4D echocardiography
• Contrast ultrasound, especially using microbubble as contrast agent to measure blood flow in the heart and other organs
• Pressure-volume loops
• Electrophysiology study and cardiac pacing

In addition to measuring cardiac functions by individual method listed above, we are proud to provide integrative measurements, such as contrast echo blood flow + PV loops, cardiac pacing + PV loops, to better support the cutting-edge research needs.

Featured Publications

View a complete list of published works in MyBibliography

• Nong Y, Guo Y, Ou Q, Gumpert A, Tomlin A, Zhu X, Bolli R. PU.1 inhibition does not attenuate cardiac function deterioration or fibrosis in a murine model of myocardial infarction. Mol Cell Biochem. 2023 Apr;478(4):927-937. doi: 10.1007/s11010-022-04561-7. Epub 2022 Sep 17. PMID: 36114991; PMCID: PMC10091869.
• Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, Elbaz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. Circulation. 2022 Apr 26;145(17):1339-1355. doi: 10.1161/CIRCULATIONAHA.121.057641. Epub 2022 Jan 21. PMID: 35061545; PMCID: PMC9038650.
• Nong Y, Guo Y, Gumpert A, Li Q, Tomlin A, Zhu X, Bolli R. Single dose of synthetic microRNA-199a or microRNA-149 mimic does not improve cardiac function in a murine model of myocardial infarction. Mol Cell Biochem. 2021 Nov;476(11):4093-4106. doi: 10.1007/s11010-021-04227-w. Epub 2021 Jul 21. PMID: 34287784; PMCID: PMC8478849.
• Bolli RAR, Arshia A, Hassan SA, Dasari C, Nong Y, Guo Y, Tomlin AA, Li Q. Cardiac Mesenchymal Cells Cultured at Physiologic Oxygen Tension Have Superior Therapeutic Efficacy in Heart Failure Caused by Myocardial Infarction. Front Cell Dev Biol. 2021 May 26;9:662415. doi: 10.3389/fcell.2021.662415. PMID: 34124043; PMCID: PMC8189180.
• Nong Y, Guo Y, Tomlin A, Zhu X, Wysoczynski M, Li Q, Bolli R. Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice. Mol Cell Biochem. 2021 May;476(5):2135-2148. doi: 10.1007/s11010-021-04077-6. Epub 2021 Feb 5. PMID: 33547546; PMCID: PMC8252912.
• Guo Y, Nong Y, Li Q, Tomlin A, Kahlon A, Gumpert A, Slezak J, Zhu X, Bolli R. Comparison of One and Three Intraventricular Injections of Cardiac Progenitor Cells in a Murine Model of Chronic Ischemic Cardiomyopathy. Stem Cell Rev Rep. 2021 Apr;17(2):604-615. doi: 10.1007/s12015-020-10063-0. Epub 2020 Oct 28. PMID: 33118146; PMCID: PMC8043991.
• Li Q, Guo Y, Nong Y, Tomlin A, Gumpert A, Zhu X, Hassan SA, Bolli R. Comparison of Repeated Doses of C-kit-Positive Cardiac Cells versus a Single Equivalent Combined Dose in a Murine Model of Chronic Ischemic Cardiomyopathy. Int J Mol Sci. 2021 Mar 19;22(6):3145. doi: 10.3390/ijms22063145. PMID: 33808720; PMCID: PMC8003463.
• Audam TN, Nong Y, Tomlin A, Jurkovic A, Li H, Zhu X, Long BW, Zheng YW, Weirick T, Brittian KR, Riggs DW, Gumpert A, Uchida S, Guo Y, Wysoczynski M, Jones SP. Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H109-H122. doi: 10.1152/ajpheart.00114.2020. Epub 2020 May 22. PMID: 32442025; PMCID: PMC7474443.
• Guo Y, Nong Y, Tukaye DN, Rokosh G, Du J, Zhu X, Book M, Tomlin A, Li Q, Bolli R. Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injury. Basic Res Cardiol. 2019 Jul 5;114(5):32. doi: 10.1007/s00395-019-0741-2. PMID: 31278427.
• Mehra P, Guo Y, Nong Y, Lorkiewicz P, Nasr M, Li Q, Muthusamy S, Bradley JA, Bhatnagar A, Wysoczynski M, Bolli R, Hill BG. Cardiac mesenchymal cells from diabetic mice are ineffective for cell therapy-mediated myocardial repair. Basic Res Cardiol. 2018 Oct 23;113(6):46. doi: 10.1007/s00395-018-0703-0. PMID: 30353243; PMCID: PMC6314032.