Education and Training:
Ph.D.: University of Louisville, Biochemistry and Molecular Biology
Postdoctoral Fellowship: Johns Hopkins University School of Medicine, Pediatric Oncology
Dr. Moore’s laboratory focuses on the use of biochemical and developmental programming strategies to investigate the genetic and molecular mechanisms modulating the survival and cardiac tissue regenerative properties of resident c-Kit+ cardiac stem cells (CSCs). The long term goal of such work is to identify molecular pathways that could be exploited, through genetic modification or pharmacological pretreatment, to enhance the therapeutic efficacy of autologous CSC infusion in patients with ischemic cardiac injury.
- Hong KU, Moore IV JB. Recent Advances in Cardiac Myocyte Biology and Function.Circulation research. 2013 Dec 6; 113(12):e121-4. doi: 10.1161/CIRCRESAHA.113.302990. Epub 2013 Dec 6.
- Henson AL, Moore IV JB, Alard P, Liu JM, Ellis SR: Mitochondrial function is impaired in yeast and human cellular models of Shwachman Diamond syndrome. Biochem Biophys Res Commun. 2013 Jul 19; 437(1):29-34. doi: 10.1016/j.bbrc.2013.06.028. Epub 2013 Jun 19.
- Moore IV JB, Farrar JE, Arceci RJ, Liu JM, and Ellis SR: Distinct Ribosome Maturation Defects in Yeast Models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome. Haematologica. 2010 Jan; 95(1):57-64. doi: 10.3324/haematol.2009.012450. Epub 2009 Aug 27.