Bradford G. Hill, Ph.D.

Assistant Professor of Medicine

Department of Medicine, Division of Cardiovascular Medicine, Center for Diabetes and Obesity Research

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Synopsis of Research:

The broad theme of my research entails understanding how changes in metabolism contribute to cardio-metabolic health and disease. This involves the critical examination of glycolysis, mitochondria, and other pathways of intermediary metabolism and the development of causal relationships between metabolic defects or signatures and (patho)physiology.

Selected Publications:

  • Salabei JK, Lorkiewicz PK, Holden CR, Li Q, Hong KU, Bolli R, Bhatnagar A, Hill BG. Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation. Stem Cells. 2015 Aug;33(8):2613-27. doi: 10.1002/stem.2047. Epub 2015 May 26. PubMed PMID: 25917428.
  • Conklin DJ, Guo Y, Jagatheesan G, Kilfoil PJ, Haberzettl P, Hill BG, Baba SP, Guo L, Wetzelberger K, Obal D, Rokosh G, Prough RA, Prabhu SD, Velayutham M, Zweier JL, Hoetker JD, Riggs D, Srivastava S, Bolli R, Bhatnagar A. Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury. Circ Res. 2015 Jul 13. pii: CIRCRESAHA.114.305518. [Epub ahead of print] PubMed PMID: 26169370.
  • Dassanayaka S, Readnower RD, Long BW, Aird AL, Zheng YT, Salabei JK, Facundo H, Hill BG*, and Jones SP*. High glucose induces mitochondrial dysfunction independent of protein O-GlcNAcylation. Biochem J 467(2): 115-126, 2015. *co-corresponding authors.
  • Sansbury BE, De Martino AM, Brooks AC, Brainard RE, Watson LJ, Holden CR, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, and Hill BG. Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail 7:634-642, 2014. PMCID:PMC4102656.
  • Salabei JK, Gibb AA, and Hill BG. Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. Nat Protoc 9(2): 421-438, 2014. PMCID: PMC4063296.
  • Watson LJ, Long BL, De Martino AM, Brittian KR, Readnower RD, Brainard RE, Cummins TD, Annamalai L, Hill BG, and Jones SP. Cardiomyocyte Ogt is essential for postnatal viability. Am J Physiol Heart Circ Physiol 306(1):H142-53, 2014. PMCID: PMC3920156.
  • Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, and Hill BG. Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab 307:E262-E277, 2014. PMCID: PMC4121575.
  • Sansbury BE and Hill BG. Regulation of obesity and insulin resistance by nitric oxide. Free Radic Biol Med 79: 383-399, 2014. PMCID: PMC4112002.
  • Sato S, Ogura Y, Shin J, Mishra V, Bhatnagar S, Hill BG, and Kumar A. TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity.  Skelet Muscle 3(1):18. 2013. PMCID: PMC3711790.
  • Salabei JK, Cummins TD, Singh M, Jones SP, Bhatnagar A, and Hill BG. PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype transition and resistance to oxidative stress.  Biochem J 451(3):375–388, 2013. PMCID: PMC4040966.
  • Zafir A, Readnower R, Long BW, McCracken J, Aird A, Alvarez A, Cummins TD, Li Q, Hill BG, Bhatnagar A, Prabhu SD, Bolli R, and Jones SP. Protein O-GlcNAcylation is a novel cytoprotective signal in cardiac stem cells. Stem Cells 31(4):765–75, 2012. PMCID: PMC3606688.
  • Sansbury BE, Cummins TD, Tang Y, Hellman J, Holden CR, Harbeson M, Chen T, Patel RP, Spite M, Bhatnagar A, and Hill BG. Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipose tissue phenotype. Circ Res 111: 1176–1189, 2012. PMCID: PMC3707504.
  • Readnower R, Brainard R, Hill BG, and Jones SP. Standardized Bioenergetic Profiling of Adult Mouse Cardiomyocytes. Physiol Genomics 44:1208-13, 2012. PMCID: PMC3544486.
  • Sansbury BE, Riggs DW, Salabei JK, Jones SP, and Hill BG. Responses of hypertrophied myocytes to stress: Implications for glycolysis and electrophile metabolism.  Biochem J 435:519–528, 2011. PMCID: PMC4072126.
  • Sansbury BE, Jones SP, Riggs DW, Darley-Usmar VM and Hill BG. Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation. Chem Biol Interact 191:288–295, 2011. PMCID: PMC3090710.
  • Hill BG, Dranka BP, Bailey SM, Lancaster Jr JR, and Darley-Usmar VM. What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology. J Biol Chem 285:19699–19704, 2010. PMCID: PMC2888379.
  • Hill BG, Dranka BP, Zou LY, Chatham JC, and Darley-Usmar VM. Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. Biochem J 424(1):99–107, 2009. PMCID: PMC2872628.
  • Hill BG, Awe SO, Vladykovskaya E, Ahmed Y, Liu SQ, Bhatnagar A, and Srivastava S. Myocardial ischemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal. Biochem J 417(2): 513–524, 2009. PMCID: PMC3463957.
  • West MB, Rokosh G, Obal D, Velayutham M, Xuan YT, Hill BG, Keith R, Schrader J, Guo Y, Conklin DJ, Prabhu SD, Zweier JL, Bolli R, and Bhatnagar A. Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition.  Circulation 118(19): 1970–1978, 2008. PMCID: PMC2763350.
  • Jones SP, Zachara NE, Ngoh GA, Hill BG, Teshima Y, Bhatnagar A, Hart GW, and Marban E. Cardioprotection by N-acetylglucosamine linkage to cellular proteins.  Circulation 117:1172–1182, 2008.