Dr. Guo directs the Murine Physiology Core in the Institute of Molecular Cardiology of the University of Louisville – a state-of-the-art laboratory that performs the most advanced and technically challenging operations in murine models of disease and that serves as the supporting core facility for almost 20 NIH grants. He has developed the first mouse model of early and late phase of ischemic preconditioning with Dr. Bolli's full support. This model represents a major advance and will be very useful for elucidating the cellular mechanisms of myocardial protection by making it possible to apply molecular biology techniques to intact animal preparations to dissect the precise roles of individual proteins. Using this reliable and physiologically-relevant mouse model, Dr. Guo has identified a specific protein, iNOS, that is responsible for the cardioprotective effects of ischemic preconditioning, one of the most powerful cardioprotective phenomenon discovered thus far. Dr. Guo possesses extensive expertise in the area of cardio-thoracic and vascular surgery, physiology, and pharmacology. His research focuses on: (i) elucidating the mechanisms of ischemic- pharmacologic- and exercise-induced preconditioning by using the ischemia/reperfusion model in genetically engineered animals, (ii) studying protection of ischemic myocardium by using gene and/or cell therapy, and (iii) elucidating adaptations to ischemia/reperfusion injury in the aging heart. Dr. Guo has published more than 44 peer-reviewed papers, three book chapters, and 80 abstracts since 1997. Dr. Guo is currently supported by seven NIH grants including one where he serves as PI.
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