Kenneth Ramos, M.D., Ph.D.

Professor

Department of Biochemistry and Molecular Biology


Baxter Biomedical Research Bldg, Suite 221, 580 S. Preston St 502-852-7340 502-852-3659 (fax) karamo01@louisville.edu

Education

Ph.D., 1983 University of Texas

M.D., 2011 University of Louisville

Research Interests

Dr. Ramos is a leading expert in the study of molecular mechanisms of environmental injury and genetic and epigenetic determinants of environmental disease.  A major thrust in his laboratory is the study of mammalian retroelements and endogenous retroviral-like sequences and their role in human disease.

Lab Personnel

Diego E. Montoya-Durango

Pasano Bojang

Alexis Hand

Selected Publications

Partridge, C.R, He, Qiang and Ramos, K.S. Genetic networks of cooperative redox regulation of osteopontin.  Matrix Biology 27(5), 462-474, Jun 2008. Epub 2008 Apr 18. PMID: 18378437.

Lu, Z., Mofang, L., Stribinskis, V., Kling, C.M., Ramos, K.S., Colburn, N.H. and Yong, Li. MicroRNA-21 Promotes Cell Transformation by Targeting the Programmed Cell Death 4 Gene.  Oncogene 27(31), 4373-4379, Jul 2008. Epub 2008 Mar 31. PMID: 18372920.

Yong, Z. and Ramos, K.S. The development of abdominal aortic aneurysms in mice is enhanced by benzo(a)pyrene.  Vascular Health and Risk Management 4(5), 1095-1102, 2008.  PMID:  19183758.

Montoya-Durango, D.E, Liu, Y. and Ramos, K.S. Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins.  Mutation Research 665(1-2), 20-28, Jun 2009. Epub 2009 Mar 9. PMID: 19427507.

Ramos, K.S. Unraveling genetic regulatory networks of mammalian retroelements.  BMC Proceedings 3, 1-3, 2009.

Ramos, K.S.  H-ras controls phenotypic profiles of vascular smooth muscle cells and the pathogenesis of vascular proliferative disorders.  Circulation Research 104, 1139-1141, 2009.

Ramos, K.S. and Nanez, A. Genetic regulatory networks of nephrogenesis:  deregulation of WT1 splicing by benzo(a)pyrene.  Birth Defects Res. Embryo Today 87:192-197, 2009.

Montoya, D.E. and Ramos, K.S.  L1 retrotransposon and retinoblastoma: Molecular linkages between epigenetics and cancer.  Current Molecular Medicine, 10, 511-521, 2010.

Rouchka, E., Montoya, D., Stribinskis,V., Ramos, K. and Kalbfleisch, T.  Assessment of genetic variation for the LINE1 retrotransposon from next generation sequence data.  BMC:  Bioinformatics, 11:S9-12, 2010.  PMID 2967742.

Lu, Z., Kumar, M., Takwi, A. Chen, W, Callander, N.S., Ramos, K.S., Young, K.H. and Li, Y.  Inactivation of tumor suppressor p53 microRNAs in multiple myeloma.  Oncogene 30, 843-853, 2011.  PMID: 20935678

Teneng, I.; Montoya-Durango, D.E.; Quertermous, J.; Lacy, M.E.; Ramos, K.S. Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulation.  Epigenetics 6, 355-367, 2011. PMID 21150308.

Ramos, K.S., Montoya,-Durango, D.E., Teneng, I., Nanez, A. and Stribinskis, V.  Epigenetic control of embryonic renal cell differentiation by L1 retrotransposon.  Birth Defects Research:  Clinical and Molecular Teratology 91, 682-692, 2011. PMID 21384534.

Bojang, P., Jr. and Ramos, K.S.  Epigenetic therapies for cancer treatment.  Cancer Treatment:  Book 1, In Tech Open Access, 2011.

Montoya, D.W and Ramos, K.S.  Retinoblastoma family of proteins and chromatin epigenetics:  A repetitive story in a few LINEs.  BioMolecular Concepts 2, 233-245,2011.

Falahatpisheh, M.H., Nanez, A. and Ramos, K.S. AHR regulates WT1 genetic programming during murine nephrogenesis.  Molecular Medicine 17, 1275-1284, 2011. PMID 21863216.

Nanez, A., Ramos, I.N. and Ramos, KS. A mutant allele of AHR protects the embryonic kidney from hydrocarbon-induced deficits in fetal programming.  Environmental Health Perspectives 119, 1745-1753, 2011.  PMID 21803694.

Montoya, D.E. and Ramos, K.S. HPV E7 viral oncoprotein disrupts transcriptional regulation of L1Md retrotransposon.  FEBS Letters 586, 102-106, 2012. PMID:  22172279.

Gao, H., Steffen, M.C. and Ramos, K.S.  Osteopontin regulates α-smooth muscle actin and calponin in vascular smooth muscle cells.  Cell Biology International 36, 155-162, 2012.  PMID: 22032345.

Ramos, I.N., He, Q. and Ramos, K.S.  Improvements in environmental health literacy following a community-wide public health educational intervention.  Environmental Justice 5, 32-37, 2012.

Williams, E.S., Partridge, C.R., Wilson, E. and Ramos, K.S.  NF-kB and matrix-dependent regulation of osteopontin promoter activity in allylamine-activated vascular smooth muscle cells.  Oxidative Medicine and Cellular Longevity 2012, 496540, 2012. PMID:  22315656.

Ramos, K.S., Stribinskis, V., Steffen, M.C., Nanez, A., and He, Q.  Albumin-like proteins are critical regulators of vascular redox signaling.  Oxidative Medicine and Longevity, 2012.