Corey Watson, Ph.D.

Associate Professor

Department of Biochemistry and Molecular Biology

319 Abraham Flexner Way, HSC-A, Room 604 502-852-8008 502-852-5694 (lab)


PhD, University of VancouverTexas



Research Interests

Mechanisms and Applications of Steroid & Peptide Hormone Action in Disease

Biochemical Techniques & Concepts for Detection and Treatment of Cancer

Laser Capture Microdissection and Its Use in Proteomics & Genomics



Research Interests

I am a geneticist with broad interests in molecular, population, and evolutionary genetics as applied to human and animal model systems. My work is generally centered on exploring the roles of genetic and epigenetic variation in functional phenotypes. Past projects have involved the analysis of candidate gene, genome-, epigenome- and transcriptome-wide datasets in the context of disease risk/progression and treatment.

Current research in the lab is focused on characterizing and cataloguing antibody genetic diversity among human populations and laboratory mouse strains, and understanding how genetic/epigenetic variation influences antibody function and development. Importantly, our ultimate aims are to explore how this information can be leveraged to inform our understanding of disease susceptibility and clinical health outcomes, such as an individual’s personalized response to infection or vaccination.

Selected Publications (All)

Joshi R., Garg P., Zaitlen N., Lappalainen T., Watson C.T., Azam N., Ho D.J., Antonarakis S.E., Brunner H.G., Buiting K., Cheung S.W., Coffee B., Eggermann T, Francis D., Geraedts J.P., Gimelli G., Jacobson S.G., Le Caignec C., de Leeuw N., Liehr T., Mackay D.J., Montgomery S.B., Pagnamenta A.T., Papenhausen P., Robinson D.O., Ruivenkamp C., Schwartz C., Steiner B., Stevenson D.A., Surti U., Wassink T. and A.J. Sharp. 2016. DNA methylation profiling of uniparental disomy cases reveals novel imprinted loci in the human genome. Am J Hum Genet. doi: 10.1016/j.ajhg.2016.06.032.

Avnir Y., Watson C.T., Glanville J., Peterson E.C., Tallarico A.S., Bennett A.S., Qin K., Fu Y., Huang C-Y, Beigel J.H., Breden F., Quan Z., and W.A. Marasco. 2016. IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity. Sci Rep. 6:20842

Watson C.T., Roussos P., Garg P., Ho D.J., Azam N., Haroutunian V., and A.J. Sharp. 2016. DNA methylation profiling in the superior temporal gyrus of Alzheimer’s disease patients reveals epigenetic patterns associated with disease pathology. Genome Med. 8(1):5

Watson C.T., Steinberg K.M., Warren R.L., Malig M., Schein J., Graves T., Wilson R.K., Holt R.A., Eichler E.E. and F. Breden. 2015. Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity. Genes Immun.16(1):24-34

Watson C.T., Marques-Bonet T., Sharp A.J. and H.C. Mefford. 2014. The Genetics of Microdeletion and Microduplication Syndromes: An Update. Annu Rev Genomics Hum Genet. 15:215-44

Watson C.T., Steinberg K.M., Huddleston J., Sudmant P., Warren R.L., Malig M., Schein J., Willsey J.A., Joy J.B., Scott J.K., Graves T., Wilson R.K., Holt R.A., Eichler E.E. and F. Breden. 2013. Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain V, D, and J Genes and Characterization of Allelic and Copy-Number Variants. Am J Hum Genet. 92(4):530-46 *Co-first authors

Watson C.T., Garg P. and A.J. Sharp. 2013. Comment on: “Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome”. PLoS Genet. 9(2): e1003332

 Watson C.T., Disanto G., Breden F., Giovannoni G. and S.V. Ramagopalan. 2012. Estimating the proportion of variation in susceptibility to multiple sclerosis captured by common SNPs. Sci Rep. 22:770

 Watson C.T. and F. Breden. 2012. The human immunoglobulin heavy chain locus: genetic diversity, missing data and implications for human disease. Genes Immun.13:363-73

 Watson C.T., Para A.E., Lincoln M.R., Ramagopalan S.V., Orton S.M., Morrison K.M., Handunnetthi L., Handel A.E., Chao M.J., Morahan J., Sadovnick A.D., Breden F. and G.C. Ebers.2011. Revisiting the T cell receptor alpha/delta locus and possible associations with multiple sclerosis. Genes Immun. 12:59-66