Dr. Wang's research has involved investigating the molecular mechanisms controlling the process of aging, at both cellular and organismic levels. Her recent work involves investigating gene-directed programs regulating the ontogeny of age-dependent diseases, and how genetic action, specifically those of the noncoding RNA, controls longevity, integrating knowledge gained from study of extreme long-lived mouse strains to identify key microRNAs for extended life span.
Bates, D. J., Li, N., Liang, R., Sarojini, H., An, J., Masternak, M. M., Bartke, A., and Wang, E. MicroRNA regulation in Ames dwarf mouse liver is linked to delayed ageing. Aging Cell 9(1):1 - 18. (2010). PMID: 19878148; NIHMSID: 158218.
Khanna, A., Muthusamy, S., Liang, R., Sarojini, H., and Wang, E. Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice. Aging 3(3): 223 - 236 (2011). PMID: 21415464.
Li, N., Bates, D. J., An, J., and Wang, E. Up-regulation of key microRNAs and the inverse down-regulation of their potential target genes of oxidative phosphorylation during aging in mouse brains. Neurobiology of Aging 32: 944–955 (2011). PMID: 19487051.
Liang, R., Khanna, A., Muthusamy, S., Li, N., Sarojini, H., Kopchick, J., Masternak, M.M., Bartke, A., and Wang, E. Posttranscriptional regulation of IGF1R by key microRNAs in longlived mutant mice. Aging Cell. 10(6): 1080-1088 (2011). PMID:21967153.
Liang, R. and Wang E. Full-length 3' Un-Translated Region reporter construction with recombineering. Analytical Biochemistry. 424: 162-167 (2012) PMID: 22366478