Alan Cheng, Ph.D.

Assistant Professor

Department of Biochemistry and Molecular Biology

319 Abraham Flexner Way, HSC-A, Room 715 502-852-3572

Research Interests

Diabetes, Obesity and Metabolism

Laboratory Personnel

Amber R. Kelly (Research Tech I)

Yuanqi Zhu (Postdoctoral Scholar)

Selected Publications

Al-Rayyan N, Litchfield LM, Ivanova MM, Radde BN, Cheng A, Elbedewy A and Klinge CM (2014) 5-aza-2-deoxycytidine and Trichostatin A increase COUP-TFII expression in anti-estrogen-resistant breast cancer cell lines, Cancer Letters, pii: S0304-3835(14)00092-5. doi: 10.1016/j.canlet.2014.02.001. [Epub ahead of print]

Andres SA, Wittliff JL and Cheng A. (2013) Protein Tyrosine Phosphatase 4A2 Expression Predicts Overall and Disease-Free Survival of Human Breast Cancer and Is Associated with Estrogen and Progestin Receptor Status, Hormones and Cancer, 4(4):208-21. doi: 10.1007/s12672-013-0141-2. Epub 2013 Apr 9.

Cheng A, Zhang M, Okubo M, Omichi K and Saltiel AR. (2009) Distinct mutations in the glycogen debranching enzyme found in Glycogen Storage Disease Type III lead to impairment in diverse cellular functions. Human Molecular Genetics, doi: 10.1093/hmg/ddp128.

Cheng A and Saltiel AR. (2009) Von Gierke’s disease adopts an orphan (and its partner). Science Signaling, 2(58): pe8

Cheng A, Zhang M, Gentry MS, Worby CA, Dixon, JE and Saltiel AR. (2007) A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori’s disease. Genes andDevelopment, 21(19):2399-409

*Cheng A, *Zhang M, Crosson SM, Bao ZQ, and Saltiel AR (2006) Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3’,5’-cyclic adenosine 5’-monophosphate in H4IIE hepatoma cells. Endocrinology 147(7):3606-12

Cheng A and Saltiel AR. (2006) More TORC for the gluconeogenic engine. Bioessays 28(3):231-4

Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, and Saltiel AR (2005) Changes in integrin expression during adipocyte differentiation. Cell Metabolism 2(3):165-177

Cheng A, Uetani N, Simoncic PD, Chaubey VP, Lee-Loy A, McGlade CJ, Kennedy BP, and Tremblay ML (2002) Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B. Developmental Cell 2(4):497-503

Tsukiyama-Kohara K., Poulin P., Kohara M., DeMaria CT., Cheng A., Wu Z., Gingras A-C., Katsume A., Elchebly M., Spiegelman BM., Harper M-E., Tremblay ML., and Sonenberg N. (2001) Adipose tissue reduction in mice lacking the translation inhibitor 4E-BP1. Nature Medicine. 7:1128-32

Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283(5407):1544-8