Selected Recent Papers 


1: Ohri SS, Hetman M, Whittemore SR. Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury. Neurobiol Dis. 2013 Oct;58:29-37. doi: 10.1016/j.nbd.2013.04.021. Epub 2013 May 6. PubMed PMID: 23659896; PubMed Central PMCID: PMC3748169.

2: Smith SC, Robinson AR, Niedernhofer LJ, Hetman M. Downregulation ofcholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice. Neurobiol Dis. 2012 Mar;45(3):1136-44. doi: 10.1016/j.nbd.2011.12.036. Epub 2011 Dec 29. PubMed PMID: 22245387; PubMed Central PMCID: PMC3345809.

3: Pietrzak M, Rempala G, Nelson PT, Zheng JJ, Hetman M. Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease. PLoS One. 2011;6(7):e22585. doi: 10.1371/journal.pone.0022585. Epub 2011 Jul 22. PubMed PMID: 21799908; PubMedCentral PMCID: PMC3142181.

4: Ohri SS, Maddie MA, Zhao Y, Qiu MS, Hetman M, Whittemore SR. Attenuating theendoplasmic reticulum stress response improves functional recovery after spinalcord injury. Glia. 2011 Oct;59(10):1489-502. doi: 10.1002/glia.21191. Epub 2011Jun 2. PubMed PMID: 21638341; PubMed Central PMCID: PMC3391751.

5: Pietrzak M, Smith SC, Geralds JT, Hagg T, Gomes C, Hetman M. Nucleolardisruption and apoptosis are distinct neuronal responses to etoposide-induced DNA damage. J Neurochem. 2011 Jun;117(6):1033-46. doi: 10.1111/j.1471-4159.2011.07279.x. Epub 2011 May 13. PubMed PMID: 21517844; PubMedCentral PMCID: PMC3107349.

6: Gomes C, Smith SC, Youssef MN, Zheng JJ, Hagg T, Hetman M. RNA polymerase 1-driven transcription as a mediator of BDNF-induced neurite outgrowth. J Biol Chem. 2011 Feb 11;286(6):4357-63. Epub 2010 Nov 23.

7: Vashishta A, Habas A, Pruunsild P, Zheng JJ, Timmusk T, Hetman M. Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci. 2009 Dec 2;29(48):15331-40.

8: Kharebava G, Makonchuk D, Kalita KB, Zheng JJ, Hetman M. Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival. J Neurosci. 2008 Oct 29;28(44):11409-20.

9: Gozdz A, Vashishta A, Kalita K, Szatmari E, Zheng JJ, Tamiya S, Delamere NA, Hetman M. Cisplatin-mediated activation of extracellular signal-regulated kinases 1/2 (ERK1/2) by inhibition of ERK1/2 phosphatases. J Neurochem. 2008 Sep;106(5):2056-67. 

10: Kalita K, Makonchuk D, Gomes C, Zheng JJ, Hetman M. Inhibition of nucleolar transcription as a trigger for neuronal apoptosis. J Neurochem. 2008 Jun 1;105(6):2286-99.



1: Hetman M, Pietrzak M. Emerging roles of the neuronal nucleolus. Trends Neurosci. 2012 May;35(5):305-314. PMID: 22305768; PubMed Central PMCID: PMC3348388.

2: Hetman M, Vashishta A, Rempala G. Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition. J Neurochem. 2010 Sep;114(6):1537-49.

3: Hetman M, Kharebava G. Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem. 2006;6(8):787-99. (click here to download a pdf file containing the manuscript)

4: Hetman M, Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem. 2004 Jun;271(11):2050-5.


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