Kentucky Spinal Cord Injury Research Center

Selected Recent Papers 

1: Pietrzak M, Smith SC, Geralds JT, Hagg T, Gomes C, Hetman M. Nucleolar disruption and apoptosis are distinct neuronal responses to etoposide-induced DNA damage. J Neurochem. 2011 Apr 21. doi: 10.1111/j.1471-4159.2011.07279.x. [Epub ahead of print] PubMed PMID: 21517844.

2: Gomes C, Smith SC, Youssef MN, Zheng JJ, Hagg T, Hetman M. RNA polymerase 1-driven transcription as a mediator of BDNF-induced neurite outgrowth. J Biol Chem. 2011 Feb 11;286(6):4357-63. Epub 2010 Nov 23.

3: Vashishta A, Habas A, Pruunsild P, Zheng JJ, Timmusk T, Hetman M. Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci. 2009 Dec 2;29(48):15331-40.

4: Kharebava G, Makonchuk D, Kalita KB, Zheng JJ, Hetman M. Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival. J Neurosci. 2008 Oct 29;28(44):11409-20.

5: Gozdz A, Vashishta A, Kalita K, Szatmari E, Zheng JJ, Tamiya S, Delamere NA, Hetman M. Cisplatin-mediated activation of extracellular signal-regulated kinases 1/2 (ERK1/2) by inhibition of ERK1/2 phosphatases. J Neurochem. 2008 Sep;106(5):2056-67. 

6: Kalita K, Makonchuk D, Gomes C, Zheng JJ, Hetman M. Inhibition of nucleolar transcription as a trigger for neuronal apoptosis. J Neurochem. 2008 Jun 1;105(6):2286-99.

7: Szatmari E, Kalita KB, Kharebava G, Hetman M. Role of kinase suppressor of Ras-1 in neuronal survival signaling by extracellular signal-regulated kinase 1/2. J Neurosci. 2007 Oct 17;27(42):11389-400.

8: Kalita K, Kharebava G, Zheng JJ, Hetman M. Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity. J Neurosci. 2006 Sep 27;26(39):10020-32.

9: Habas A, Kharebava G, Szatmari E, Hetman M. NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis. J Neurochem. 2006 Jan;96(2):335-48.

REVIEWS:

1: Hetman M, Vashishta A, Rempala G. Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition. J Neurochem. 2010 Sep;114(6):1537-49.

2: Hetman M, Kharebava G. Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem. 2006;6(8):787-99. (click here to download a pdf file containing the manuscript)

3: Hetman M, Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem. 2004 Jun;271(11):2050-5.