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Theo Hagg, M.D., Ph.D.

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Theo Hagg, M.D., Ph.D.
Endowed Chair Professor

 

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Research Description

 

The Hagg lab investigates how novel neurotrophic mechanisms and endogenous stem cells might be used to develop CNS repair strategies.  We are currently investigating how small molecules that activate neuroprotective mechanisms might be used to reduce axon and myelin loss after a contusive spinal cord injury.  We also investigate how vascular-related mechanisms could be utilized to reduce degeneration after such injuries.  Lastly, we are identifying molecular regulators of endogenous neural precursors in adult rodents which can be targeted for enhancing neurogenesis and redirect neuroblast migration.  The long term goal of these studies is to provide information that would lead to better treatment strategies for a variety of human neurological disorders, including spinal cord injury. Techniques used routinely include various refined microsurgical procedures in the brain and spinal cord of adult rats and mice, regular and confocal immunohistochemistry, Western blotting and real-time PCR.  We are members of the world-class Kentucky Spinal Cord Injury Research Center, and collaborate with many other laboratories and biotechnology companies in Canada, U.S.A. and Europe.

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