Michael H. Nantz, Ph. D.

Professor & Chair of Chemistry

Distinguished University Scholar

Phone Number: (502) 852 8069 (Office)
Fax Number: (502)-852-7214
Email michael.nantz@louisville.edu

Address: Department of Chemistry
University of Louisville
Louisville, KY 40292


Additional Appointments:

  • Professor, Chemistry Department, University of Louisville

Education:

  • Ph. D. 1987, Purdue University

Laboratory Team Members:

Graduate Students:

Stephanie Mattingly
Ralph Knipp
Sadakatali Gori
Sara Biladeau
Mumiye Ogunawale

 

Undergraduate Students:

Joseph Moore [present position: graduate student, Dept. of Chemistry, Univ. of Wisconsin]
Corey Brown [present position: student, School of Pharmacy, Univ. of Kentucky]
Clayton J Peace [present position: graduate student, Dept. of Chemistry, Univ. of Iowa]
Leah M Johannes [present position: student, College of Pharmacy, Sullivan University]
Kelly A Beglin [present position: student, School of Dentistry, Univ. of Louisville]
Tyler E Geers [present position: student, School of Medicine, Univ. of Louisville]
Daniel Ehringer [present position: postbac student, Univ. of Louisville]
Michael E Parsons [present position: postbac student, Univ. of Louisville]
Olivetta Uradu [present position: undergraduate student, Univ. of Louisville]
Erica James [present position: undergraduate student, Univ. of Louisville]

 

Research Focus:

Cationic Lipids and Polymers for Gene Delivery

Peptide-Based Prodrugs for Cancer Chemotheraputics

Applications of Nanoparticle-peptide conjugates

 

Selected Publications:

  • O'Toole MG, Soucy PA, Chauhan R, Raju MV, Patel DN, Nunn BM, Keynton MA, Ehringer WD, Nantz MH, Keynton RS, Gobin AS. Release-Modulated Antioxidant Activity of a Composite Curcumin-Chitosan Polymer. Biomacromolecules. 2016 Apr 11;17(4):1253-60. doi: 10.1021/acs.biomac.5b01019. Epub 2016 Mar 4. PubMed PMID: 26908114.
  • Li M, Yang D, Brock G, Knipp RJ, Bousamra M, Nantz MH, Fu XA. Breath carbonyl compounds as biomarkers of lung cancer. Lung Cancer. 2015 Oct;90(1):92-7. doi: 10.1016/j.lungcan.2015.07.005. Epub 2015 Jul 19. PubMed PMID: 26233567.
  • Lane AN, Arumugam S, Lorkiewicz PK, Higashi RM, Laulhé S, Nantz MH, Moseley HN, Fan TW. Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance. Magn Reson Chem. 2015 May;53(5):337-43. doi: 10.1002/mrc.4199. Epub 2015 Jan 23. PubMed PMID: 25616249; PubMed Central PMCID: PMC4409496.
  • Mattingly SJ, O'Toole MG, James KT, Clark GJ, Nantz MH. Magnetic nanoparticle-supported lipid bilayers for drug delivery. Langmuir. 2015 Mar 24;31(11):3326-32. doi: 10.1021/la504830z. Epub 2015 Mar 11. PubMed PMID: 25714501.
  • Grodzki AC, Poola B, Pasupuleti N, Nantz MH, Lein PJ, Gorin F. A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor α and interleukin-1β expression. J Pharmacol Exp Ther. 2015 Mar;352(3):438-47. doi: 10.1124/jpet.114.220186. Epub 2014 Dec 23. PubMed PMID: 25538105; PubMed Central PMCID: PMC4352593.
  • Gupta K, Mattingly SJ, Knipp RJ, Afonin KA, Viard M, Bergman JT, Stepler M, Nantz MH, Puri A, Shapiro BA. Oxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts. Nanomedicine (Lond). 2015;10(18):2805-18. doi: 10.2217/nnm.15.105. Epub 2015 Jun 24. PubMed PMID: 26107486; PubMed Central PMCID: PMC4636123.
  • Bousamra M 2nd, Schumer E, Li M, Knipp RJ, Nantz MH, van Berkel V, Fu XA. Quantitative analysis of exhaled carbonyl compounds distinguishes benign from malignant pulmonary disease. J Thorac Cardiovasc Surg. 2014 Sep;148(3):1074-80; discussion 1080-1. doi: 10.1016/j.jtcvs.2014.06.006. Epub 2014 Jun 8. PubMed PMID: 25129599.
  • Gori SS, Lorkiewicz P, Ehringer DS, Belshoff AC, Higashi RM, Fan TW, Nantz MH. Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry. Anal Bioanal Chem. 2014 Jul;406(18):4371-9. doi: 10.1007/s00216-014-7810-z. Epub 2014 May 25. PubMed PMID: 24858467; PubMed Central PMCID: PMC4144182.
  • Knipp RJ, Estrada R, Sethu P, Nantz MH. Thermally-Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates. Tetrahedron. 2014 May 1;70(21):3422-3429. PubMed PMID: 25061237; PubMed Central PMCID: PMC4104717.
  • Fu XA, Li M, Knipp RJ, Nantz MH, Bousamra M. Noninvasive detection of lung cancer using exhaled breath. Cancer Med. 2014 Feb;3(1):174-81. doi: 10.1002/cam4.162. Epub 2013 Nov 20. PubMed PMID: 24402867; PubMed Central PMCID: PMC3930402.
  • Laulhé S, Geers TE, Shi X, Zhang X, Nantz MH. Electron Ionization-Induced Release of Coded Isotopic Reporter Ions in an <i>m/z</i> Zone of Minimal Interference for Quantifiable, Multiplexed GC-MS Analyses. Anal Methods. 2013 Sep 21;5(18). doi: 10.1039/C3AY41124A. PubMed PMID: 24235976; PubMed Central PMCID: PMC3822575.
  • Mattingly SJ, Xu T, Nantz MH, Higashi RM, Fan TW. A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts. Metabolomics. 2012;8(6):989-996. Epub 2012 Jan 19. PubMed PMID: 23175637; PubMed Central PMCID: PMC3501132.

 

Recent Patents & Licenses:

  • P1. MH Nantz, MJ Bennett and RW Malone, Cationic Transport Reagents, Filed: September 30, 1994; Issued: June 18, 1996, United States Patent No. 5,527,928, Patent licensed to Promega Corporation, Madison, WI.
  • P2. MH Nantz, MJ Bennett and RW Malone, Cationic Transport Reagents (Divisional), Filed: May 16, 1996; Issued: April 28, 1998, United States Patent No. 5,744,625, Patent licensed to Promega Corporation, Madison, WI.
  • P3. MH Nantz, MJ Bennett, RP Balasubramaniam, AM Aberle and RW Malone, Polyfunctional Cationic Cytofectins, Formulations and Methods for Generating Active Cytofectin–Polynucleotide Transfection Complexes, Filed: September 17, 1996; Issued: October 20, 1998, United States Patent No. 5,824,812, Patent licensed to Promega Corporation, Madison, WI.
  • P4. MH Nantz, MJ Bennett and RP Balasubramaniam, Polyfunctional Cationic Cytofectins, Filed: September 27, 1995; Issued: February 9, 1999, United States Patent No. 5,869,715, Patent licensed to Promega Corporation, Madison, WI.
  • P5. MH Nantz, MJ Bennett and RW Malone, Cationic Transport Reagents (CIP), Filed: September 15, 1995; Issued: April 6, 1999, United States Patent No. 5,892,071, Patent licensed to Promega Corporation, Madison, WI.
  • P6. MH Nantz, MJ Bennett, RP Balasubramaniam, AM Aberle and RW Malone, Formulations and Methods for Generating Active Cytofectin–Polynucleotide Transfection Complexes, Filed: July 15, 1996; Issued: July 20, 1999, United States Patent No. 5,925,623, Patent licensed to Promega Corporation, Madison, WI.
  • P7. MH Nantz and AM Aberle, Pentaerythritol Lipid Derivatives, Filed: April 3, 1998; Issued: March 28, 2000, United States Patent No. 6,043,390
  • P8. MH Nantz and J Zhu, Ortho Ester Lipids, Filed: October 7, 1999; Issued: March 13, 2001, United States Patent No. 6,200,599
  • P9. MH Nantz and AM Aberle, Pentaerythritol Lipid Derivatives (Divisional), Filed: March 27, 2000; Issued: November 13, 2001, United States Patent No. 6,316,421
  • P10. MJ Bennett, MH Nantz and SS Rothman, Method for Nucleic Acid Transfection of Cells, Filed: January 20, 2000; Issued: April 16, 2002, United States Patent No. 6,372,722
  • P11. MJ Bennett, SS Rothman and MH Nantz, Method for Nucleic Acid Transfection of Cells (Divisional), Filed: January 18, 2001; Issued: September 23, 2003, United States Patent No. 6,624,149
  • P12.    FA Gorin and MH Nantz, Amino Acid and Peptide Conjugates of Amiloride and Methods of Use Thereof, Filed: January 21, 2005; Issued: January 4, 2011, United States Patent No. 7,863,415
  • P13.    FA Gorin and MH Nantz, Inhibitors of Intracellular Urokinase Plasminogen Activator and Methods of Use Thereof, Filed: January 13, 2012; Issued: October 1, 2013, United States Patent No. 8,546,322
  • PENDING    MH Nantz and S Biswas, Nanoparticles for Drug Delivery, Filed October 19, 2010, US Patent Application 13/502941 (published November 29, 2012), Priority: US Provisional Application 61/252,934; Filed October 19, 2009
  • PENDING    X-A Fu, R Higashi and MH Nantz, Pre-Concentrator and Method of Using the Same, Filed March 27, 2012, US Patent Application 13/431054 (published October 4, 2012),       Priority: US Provisional Application 61/468,436; Filed March 28, 2011
  • PENDING    MH Nantz and RJ Knipp, Therapeutic Nanoparticles, US Provisional Application 61/762,832; Filed February 8, 2013