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Teresa Fan, Ph.D.

by Wittliff,James L. last modified Dec 07, 2009 12:20 PM

Associate Professor of Chemistry & Brown Cancer Center

FanEmail Teresa Fan
Phone Number: (502) 852-6448 (Office)
Fax Number: (502) 852-8149
Ph. D. 1983, University of California, Davis

 


 

 

 

Research Interests:

  • Use of metabolomics and transcriptomics for probing metabolic regulation and adaptation in response to environmental perturbations.
  •  Molecular mechanism of Se chemoprevention in human cancers
  • Translation of basic metabolic knowledge into functional diagnostic markers and molecular targets for cancers.

 

Investigators:

  • Tim Colmer, Ph. D in Plant Biology, Univ. of California, Davis
  • Liese Schultz, Ph. D, Soil Science Graduate group, Univ. of California, Davis
  • Mike Carriere, Ph. D, Plant Biology Graduate group, Univ. of California, Davis
  • Steven Detwiler, Ph. D, Ecology Graduate group, Univ. of California, Davis
  • Sarah Norris, M.S., Soil Science Graduate group
  • Robert Kaufman, Ph.D student, Pharmacology & Toxicology Graduate group, Univ. of California, Davis
  • Dan Curda, Ph. D student, Agricultural Chemistry Graduate group, Univ. of California, Davis
  • Wendy Rose, Ph.D., Pharmacology & Toxicology, Univ. of California, Davis
  • Steven Xu, M.S., Department of Pharmacology and Toxicology, Univ. of Louisville
  • Alan Brroks, medical student, Univ. of Louisville
  • Ricky Woofter, Ph.D student, Univ. of Louisville

 

Selected Publications:

  1. Lane AN, Fan TW, Higashi RM, Tan J, Bousamra M, Miller DM; Prospects for clinical cancer metabolomics using stable isotope tracers. Exp. Mol. Pathol. 86 (3):165-173, 2009
  2. Fan, TW, Higashi RM, Bousamra, M, Kloecker, G, Miller, DM; Metabolic Profiling Identifies Lung Cancer Responsiveness to Erlotinib. Exp. Mol. Pathol, 2009, 87(1):83-86.
  3. Fan TW, Lane AN, Higashi RM, Farag MA, Gao H, Bousamra M, Miller DM. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 2009 8:41.
  4. “Sensitivity to Sodium Arsenite Depends upon Susceptibility to Arsenite-Induced Mitotic Arrest”, McNeely, S.C., Belshoff, A.C., Frazier, B.T., Fan, T.W., McCabe, Jr, M.J., Pinhas, A.R., and States, J. C., Toxicology & Applied Pharmacology, 229(2), 252-261 (2008).
  5. “Proposed Minimum Reporting Standards for Chemical Analysis”, Sumner, L.W., Amberg, A., Barrett, D., Beger, R., Beale, M.H., Daykin, C, Fan, T.W.-M., Fiehn, O, Goodacre, R., Griffin, J.L., Higashi, R., Kopka, J., Lindon, J.C., Lane, A.N., Marriott, P, Nicholls, A.W., Reily, M.D., and Mark, Viant, Metabolomics Journal, 3, 211-221 (2007).
  6. “The Metabolomics Standards Initiative (MSI)”, Sansone, S., Nikolau, B., van Ommen, B., Kristal, B., Taylor, C., Robertson, D., Lindon, J., Griffin, J., Sumner, L., van der Werf, M., Hardy, N., Morrison, N., Mendes, P., Kaddurah-Daouk, R., Goodacre, R., Fan, T., and Fiehn, O., Nature Biotechnology, 25(8), 2-4 (2007).
  7. “Quantification and Identification of Isotopomer Distributions of Metabolites in Crude Cell Extracts Using 1H TOCSY”, Lane, A. N and Fan, T.W.-M., Metabolomics, 3, 79-86 (2007).
  8. Podrabsky, J. E., Lopez, J. P., Fan, T. W., Higashi, R. and Somero, G. N. (2007) Extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus: insights from a metabolomics analysis. J Exp Biol. 210, 2253-2266.
  9. “Relationships between Sediment Microbial Communities and Pollutants in Two California Salt Marshes”, YiP.I.ng Cao, Gary N. Cherr, Ana Lucía Córdova, Teresa W.-M. Fan, Rick M. Higashi, Michael G. LaMontagne, Kate M. Scow, Jiacheng Yuan, and Patricia A. Holden, Microbial Ecology, 52(4), 619-633 (2006).
  10. “Using an integrated approach to link biomarker responses and physiological stress to growth impairment of cadmium-exposed larval topsmelt”, Rose, W.L., Nisbet, R.M., Green, P.G., Norris, S., Fan, T., Smith, E.H., Cherr, G.N. and Anderson, S.L., Aquatic Toxicology, 80, 298-308 (2006).
  11. "Metabolomics-Edited Transcriptomics Analysis of Se Anticancer Action in human lung cancer cells", Fan, T.W-M, Bandura, L., Higashi, R.M., Lane, A.N., Metabolomics Journal, 1(4), 325-339 (2006).
  12. “13C-Tracer Studies of Soil Humic Substructuresthat Reduce Heavy Metal Leaching”, Richard M. Higashi, Teresa Cassel, Peter G. Green, and Teresa W.-M. Fan In: Subsurface Contamination Remediation, Symposium Series No. 904, eds. Edgar Berkey and Tiffany Zachry, American Chemical Society, 138-157, 2005.
  13. “Interactive effect of cadmium and soil humates on metal acquisition and sequestration in wheat, Baraud, F., Fan, T.W-M., and Higashi, R.M. Environmental Chemistry, E. Lichtfouse, S. Dudd, D. Robert, eds., pp. 205-214, Springer, 2005.
  14. “Chronic Effects of Dietary Selenium on Juvenile Sacramento Splittail (Pogonichthys macroleP.I.dotus)”, Teh, S.J., Deng, X., Deng, D.-F,.Teh, F.-C,.Hung, S.S.O., Fan, T.W.-M., Liu, J., and Higashi, R.M., Environmental Science and Technology, 38(22), 6085-6093 (2004).
  15. “Synthesis and Physico-Chemical Properties of Peptides in Soil Humic Substances”, Fan, T.W-M., Lane, A.N., Chekmenev, E., Wittebort, R.J., and Higashi, R.M., Journal of Peptide Research, 63(3), 253-264 (2004).
  16. “Secondary structure and stability of the selenocysteine insertion sequences (SECIS) for human thioredoxin reductase and glutathione peroxidase”, Ramos, A., Lane, A.N., Hollingworth, D., and Fan, T.W.-M., Nucleic Acids Research, 32(5), 1746-1755 (2004).
  17. “An Electrophoretic Profiling Method for Thiol-Rich Phytochelatins and Metallothioneins”, Fan, T.W-M., Lane, A.N., and Higashi, R.M., Phytochemical Analysis, 15, 175-183 (2004).
  18. “In vivo and in vitro metabolomic analysis of anaerobic rice coleoptiles revealed unexpected pathways”, Fan, T.W-M., Lane, A.N., and Higashi, R.M., Russian Journal of Plant Physiology, 50(6), 787-793 (2003).
  19. “Speciation of selenoproteins in se-contaminated wildlife by gel electrophoresis and laser ablation-ICPMS”, T.W.-M. Fan, E. Pruzkowski, and S. Shuttleworth, Journal of Analytical Atomic Spectrometry, 17, 1621-1623 (2002).
  20. “Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California”, Fan, T.W.-M., Teh, S., Hinton, D.E., and Higashi, R.M., Aquatic Toxicology, 57 (1-2), 65-84 (2002) (a special Se issue with Fan as a guest editor).
  21. “Speciation of selenoamino acids, selenonium ions and inorganic selenium by ion exchange HPLC with mass spectrometric detection and its application to yeast and algae”, Larsen, E. H., Hansen, M., Fan, T., Vahl, M., J. Anal. At. Spectrom., 16(12),  1403-1408 (2001).
  22. “Phytosiderophores Influence on Cadmium Mobilization and Uptake by Wheat and Barley Plants”, M. Shenker, T.W.-M.Fan, and D.E. Crowley, J. Environ. Quality 30, 2091-2098 (2001).
  23. “Comprehensive chemical profiling of gramineous plant root exudates using high-resolution NMR and MS”. Fan, T.W.-M, Lane, A.N., Shenker, M., Bartley, J.P., Crowley, D. and Higashi, R.M.  Phytochem. 57, 209-221 (2001).
  24. “GenotyP.I.c influence on metal ion mobilization and sequestration via metal ion ligand production by wheat”. Fan, T.W.-M., Baraud, F., Higashi, R.M., eds. Eller, P.G. and Heineman, W.R. 2000.  In: Nuclear Site Remediation. American Chemical Society Symposium Series, vol. 778, pp. 417-431, Washington, D.C.
  25. “Chemical Characterization of a Chelator-Treated Soil Humate by Solution-State Multinuclear Two-Dimensional NMR with FTIR and Pyrolysis-GCMS”, Fan, T. W.-M., R. M. Higashi and A. N. Lanes, Environmental Science and Technology 34, 1636-1646 (2000).

 

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