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Muriel C. Maurer, Ph.D.

by Wittliff,James L. last modified Oct 24, 2013 04:26 PM

Professor and Vice-Chair of Chemistry

MaurerEmail Muriel Maurer
Phone Number: (502) 852-7008 (Office)
Fax Number: (502) 852-8149
Address: Department of Chemistry
University of Louisville
Louisville, KY 40292
Ph. D. 1993, University of Virginia

 

Investigators:

  • Kelly Mouapi, Graduate Student
  • Ramya Billur, Graduate Student
  • Blake Lynch, Undergraduate Student
  • Sara Zink, Undergraduate Student

 

Research Interests:

  • Biochemistry: protein-structure function relationships, enzyme-ligand interactions
  • Blood Coagulation: Factor XIII, Thrombin, Fibrinogen, Protease Activated Receptors
  • Methods: enzyme kinetics, Nuclear Magnetic Resonance, MALDI-TOF mass spectrometry, amide proton hydrogen/deuterium exchange, chemical modifications

 

Selected Publications:

    1. M.V. Malovichko, T.M.Sabo, M.C. Maurer (2013) “Ligand Binding to Anion Binding Exosites Regulates Conformational Properties of Thrombin” J. Biol. Chem. 288, 8667-78.
    2. M.C. Maurer (2012) “Liberating R169 promotes anticoagulant protein C” Blood 120, 501-502. 
    3. M.A. Jadhav, R.C. Lucas, W.N. Goldsberry, M.C. Maurer (2011) “Design of Factor XIII V34X Activation Peptides to Control Ability to Interact with Thrombin Mutants”  Biochim. Biophys. Acta 1814, 1955-63.
    4. R.T. Woofter, M. C. Maurer (2011) “Role of Calcium in the Conformational Dynamics of Factor XIII Activation Examined by Hydrogen-Deuterium Exchange Coupled with MALDI-TOF MS” Archives of Biochemistry and Biophysics 512, 87-95.
    5. M.C. Maurer (2011) “Switching Cation-Binding Loops Paves the Way for Redesigning Allosteric Activation” PNAS 108, 5145-5146.
    6. M.A. Jadhav, G. Isetti, Trumbo, T.A., M.C. Maurer (2010) “Effects of Introducing Fibrinogen Aα Character into the Factor XIII Activation Peptide Segment” Biochemistry 49, 2918-24.
    7. D.B. Cleary, P. Doiphode, M.C. Maurer (2009) “A Non-Reactive Glutamine Residue of α2-Antiplasmin Promotes Interactions with the Factor XIIIa Active Site Region” J. Thromb. Haemost. 7, 1947-1949. 
    8. T.M. Sabo, M.C. Maurer (2009) “Biophysical Investigation of GpIbα Binding to Thrombin Anion Binding Exosite II” Biochemistry 48, 7110-7122. PMID:  19591434
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