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Michael H. Nantz, Ph.D.

by Wittliff,James L. last modified Oct 24, 2013 04:19 PM

Professor of Chemistry & Distinguished University Scholar

NantzEmail Michael Nantz
Phone Number: (502) 852 8069 (Office)
Fax Number: (502)-852-7214
Address: Department of Chemistry
University of Louisville
Louisville, KY 40292
Ph. D. 1987, Purdue University

Additional Appointments:

  • Professor, Chemistry Department, University of Louisville

 

Graduate Students:

  • Stephanie Mattingly
  • Ralph Knipp
  • Sadakatali Gori
  • Sara Biladeau
  • Mumiye Ogunawale

Undergraduate Students:

  • Joseph Moore  [present position: graduate student, Dept. of Chemistry, Univ. of Wisconsin]
  • Corey Brown  [present position: student, School of Pharmacy, Univ. of Kentucky]
  • Clayton J Peace  [present position: graduate student, Dept. of Chemistry, Univ. of Iowa]
  • Leah M Johannes  [present position: student, College of Pharmacy, Sullivan University]
  • Kelly A  Beglin  [present position: student, School of Dentistry, Univ. of Louisville]
  • Tyler E Geers  [present position: student, School of Medicine, Univ. of Louisville]
  • Daniel Ehringer  [present position: postbac student, Univ. of Louisville]
  • Michael E Parsons  [present position: postbac student, Univ. of Louisville]
  • Olivetta Uradu  [present position: undergraduate student, Univ. of Louisville]
  • Erica James  [present position: undergraduate student, Univ. of Louisville]
 

Research Interests:

  • Cationic Lipids and Polymers for Gene Delivery
  • Peptide-Based Prodrugs for Cancer Chemotheraputics
  • Applications of Nanoparticle-peptide conjugates

 

Selected Publications:

  1. S Biswas, X Huang, WR Badger and MH Nantz.  Aminooxy Cation-ization Reagents.  Tetrahedron Letters 51, 1727–1729, 2010.
  2. S Zou, KA Scarfo, MH Nantz and JG Hecker.  Lipid-Mediated Delivery of RNA is More Efficient than Delivery of DNA in Non-Dividing Cells.  International Journal of Pharmaceutics 389, 232–243, 2010.
  3. MH Nantz, CW Dicus, B Hilliard, S Yellayi, S Zou and JG Hecker.  The Benefit of Hydrophobic Domain Asymmetry on the Efficacy of Transfection as Measured by In Vivo Imaging.  Molecular Pharmaceutics 7, 786–794, 2010.
  4. WR Harley, CL Floyd, TN Dunn, X-D Zhang, T-Y Chen, M Hegde, H Palandoken, MH Nantz, L Leon, KL Carraway III, BG Lyeth and FA Gorin.  Dual Inhibition of Sodium-Mediated Proton and Calcium Efflux Triggers Non-Apoptotic Cell Death in Malignant Gliomas.  Brain Research 1363, 159–169, 2010.
  5. S Biswas, LE Gordon, GJ Clark and MH Nantz.  Click Assembly of Magnetic Nanovectors for Gene Delivery.  Biomaterials 32, 2683–2688, 2011.
  6. J Wang, S Achilefu, MH Nantz and KA Kang.  Gold Nanoparticle-Fluorophore Complex for Conditionally Fluorescing Signal Mediator.  Analytica Chimica Acta 695, 96–104, 2011.
  7. J Wang, MG O'Toole, AP Massey, S Biswas, MH Nantz, S Achilefu and KA Kang.  Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticles.  Advances in Experimental Medicine and Biology 701, 149–154, 2011.
  8. S Laulhé and MH Nantz.  An Improved Preparation of O-Diphenylphos-phinylhydroxylamine.  Organic Preparations & Procedures, Int. 43, 475–476, 2011.
  9. S Yellayi, B Hilliard, M Ghazanfar, A Tsingalia, MH Nantz, L Bollinger, F de Kok-Mercado and JG Hecker.  A Single Intrathecal Injection of DNA and an Asymmetric Cationic Lipid as Lipoplexes Ameliorates Experimental Autoimmune Encephalomyelitis.  Molecular Pharmaceutics 8, 1980–1984, 2011. 
  10. X-A Fu, M Li, S Biswas, MH Nantz and RM Higashi.  A Novel Microreactor Approach for Analysis of Ketones and Aldehydes in Breath.  Analyst 136, 4662–4666, 2011.
  11. S Biswas, RJ Knipp, LE Gordon, SR Nandula, S-U Gorr, GJ Clark and MH Nantz.  Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids.  ChemMedChem 6, 2063–2069, 2011.
  12. M Li, S Biswas, MH Nantz, RM Higashi and X-A Fu.  Preconcentration and Analysis of Trace Volatile Carbonyl Compounds.  Analytical Chemistry 84, 1288–1293, 2012.
  13. J Wang, JD Moore, S Laulhé, MH Nantz, S Achilefu and KA Kang.  Fluorophore-Gold Nanoparticle Complex for Sensitive Optical Biosensing and Imaging.  Nanotechnology 23, 095501 (13pp), 2012.
  14. AP Massey, WR Harley, N Pasupuleti, FA Gorin and MH Nantz. 2-Amidino Analogs of Glycine-Amiloride Conjugates: Inhibitors of Urokinase-type Plasminogen Activator.  Bioorganic & Medicinal Chemistry Letters 22, 2635–2639, 2012.
  15. KA Kang, J Wang, MG O'Toole, MH Nantz, JD Moore, S Laulhé and S Achilefu.  Sensitivity Enhancement of NIR Fluorescence Contrast Agent Utilizing Gold Nanoparticles.  Advances in Experimental Medicine and Biology 737, 285–291, 2012.
  16. S Laulhé, B Bogdanov, LM Johannes, O Gutierrez, JG Harrison, DJ Tantillo, X Zhang and MH Nantz.  Fragmentation of Oxime and Silyl-Oxime Ether Odd-Electron Positive Ions by the McLafferty Rearrangement:  New Insights on Structural Factors That Promote a,b-Fragmentation.  Journal of Mass Spectrometry 47, 676–686, 2012.
  17. S Laulhé, SS Gori and MH Nantz.  A  Chemoselective, One-Pot Transformation of Aldehydes to Nitriles.  Journal of Organic Chemistry 77, 9334–9337, 2012.
  18. SJ Mattingly, T Xu, MH Nantz, RM Higashi and TW-M Fan.  A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts.  Metabolomics 8, 989–996, 2012.
  19. M Li, S Biswas, MH Nantz, RM Higashi and X-A Fu.  A Microfabricated Preconcentration Device for Breath Analysis.  Sensors and Actuators 180, 130–136, 2013.
  20. S Laulhé, TE Geers, X Shi, X Zhang and MH Nantz.  Electron Ionization-Induced Release of Coded Isotopic Reporter Ions in an m/z Zone of Minimal Interference for Quantifiable, Multiplexed GC-MS Analyses.  Analytical Methods 5, 4701–4706, 2013.

 

Patents & Licenses:

  • P1. MH Nantz, MJ Bennett and RW Malone, Cationic Transport Reagents, Filed: September 30, 1994; Issued: June 18, 1996, United States Patent No. 5,527,928, Patent licensed to Promega Corporation, Madison, WI.
    • P2. MH Nantz, MJ Bennett and RW Malone, Cationic Transport Reagents (Divisional), Filed: May 16, 1996; Issued: April 28, 1998, United States Patent No. 5,744,625, Patent licensed to Promega Corporation, Madison, WI.
      • P3. MH Nantz, MJ Bennett, RP Balasubramaniam, AM Aberle and RW Malone, Polyfunctional Cationic Cytofectins, Formulations and Methods for Generating Active Cytofectin–Polynucleotide Transfection Complexes, Filed: September 17, 1996; Issued: October 20, 1998, United States Patent No. 5,824,812, Patent licensed to Promega Corporation, Madison, WI.
        • P4. MH Nantz, MJ Bennett and RP Balasubramaniam, Polyfunctional Cationic Cytofectins, Filed: September 27, 1995; Issued: February 9, 1999, United States Patent No. 5,869,715, Patent licensed to Promega Corporation, Madison, WI.
          • P5. MH Nantz, MJ Bennett and RW Malone, Cationic Transport Reagents (CIP), Filed: September 15, 1995; Issued: April 6, 1999, United States Patent No. 5,892,071, Patent licensed to Promega Corporation, Madison, WI.
            • P6. MH Nantz, MJ Bennett, RP Balasubramaniam, AM Aberle and RW Malone, Formulations and Methods for Generating Active Cytofectin–Polynucleotide Transfection Complexes, Filed: July 15, 1996; Issued: July 20, 1999, United States Patent No. 5,925,623, Patent licensed to Promega Corporation, Madison, WI.
              • P7. MH Nantz and AM Aberle, Pentaerythritol Lipid Derivatives, Filed: April 3, 1998; Issued: March 28, 2000, United States Patent No. 6,043,390
                • P8. MH Nantz and J Zhu, Ortho Ester Lipids, Filed: October 7, 1999; Issued: March 13, 2001, United States Patent No. 6,200,599
                  • P9. MH Nantz and AM Aberle, Pentaerythritol Lipid Derivatives (Divisional), Filed: March 27, 2000; Issued: November 13, 2001, United States Patent No. 6,316,421
                    • P10. MJ Bennett, MH Nantz and SS Rothman, Method for Nucleic Acid Transfection of Cells, Filed: January 20, 2000; Issued: April 16, 2002, United States Patent No. 6,372,722
                      • P11. MJ Bennett, SS Rothman and MH Nantz, Method for Nucleic Acid Transfection of Cells (Divisional), Filed: January 18, 2001; Issued: September 23, 2003, United States Patent No. 6,624,149
                      • P12.    FA Gorin and MH Nantz, Amino Acid and Peptide Conjugates of Amiloride and Methods of Use Thereof, Filed: January 21, 2005; Issued: January 4, 2011, United States Patent No. 7,863,415
                      • P13.    FA Gorin and MH Nantz, Inhibitors of Intracellular Urokinase Plasminogen Activator and Methods of Use Thereof, Filed: January 13, 2012; Issued: October 1, 2013, United States Patent No. 8,546,322
                      • PENDING    MH Nantz and S Biswas, Nanoparticles for Drug Delivery, Filed October 19, 2010, US Patent Application 13/502941 (published November 29, 2012), Priority: US Provisional Application 61/252,934; Filed October 19, 2009
                      • PENDING    X-A Fu, R Higashi and MH Nantz, Pre-Concentrator and Method of Using the Same, Filed March 27, 2012, US Patent Application 13/431054 (published October 4, 2012),       Priority: US Provisional Application 61/468,436; Filed March 28, 2011
                      • PENDING    MH Nantz and RJ Knipp, Therapeutic Nanoparticles, US Provisional Application 61/762,832; Filed February 8, 2013
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