Email Michael Nantz
Phone Number: (502) 852 8069 (Office)
Fax Number: (502)-852-7214
Address: Department of Chemistry
University of Louisville
Louisville, KY 40292
Ph. D. 1987, Purdue University

Additional Appointments:

• Professor, Chemistry Department, University of Louisville

Investigators:

• Mr. Xuan Huang (4th year graduate student)
• Mr. Souvik Biswas (3rd year graduate student)
• Mr. Sebastien Laulhe (2nd year graduate student)
• Ms. Stephanie Mattingly (1st year graduate student)

Research Interests:

• Cationic Lipids and Polymers for Gene Delivery
• Peptide-Based Prodrugs for Cancer Chemotheraputics
• Applications of Nanoparticle-peptide conjugates

Selected Publications:

1. Modern Organic Synthesis: An Introduction GS Zweifel and MH Nantz.  WH Freeman & Co.: New York, 2006; ISBN: 0-7167-7266-3 (504 pages). 
   
2. Solutions Manual for Modern Organic Synthesis MH Nantz, H Palandoken and GS Zweifel.  WH Freeman & Co.: New York, 2006; ISBN: 0-7167-7494-1 (218 pages). 

1. Activation of CFTR by UCCF-029 and Genistein L Al-Nakkash, MF Springsteel, MJ Kurth and MH Nantz.  Bioorganic & Medicinal Chemistry Letters 2008, 18, 3874-3877.
   
2. A Flexible Method for the Conjugation of Aminooxy Ligands to Pre-Formed Complexes of Nucleic Acids and Lipids. JG Hecker, GO Berger, KA Scarfo, S Zou and MH Nantz.  ChemMedChem 2008, 3, 1356-1361.
   
3. A  Mild, Catalyst-Free Synthesis of 2-Aminopyridines B Poola, W Choung and MH Nantz.  Tetrahedron 2008, 64, 10798-10801.
   
4. Whole Animal In Vivo Imaging After Transient Nonviral Gene Delivery to the Rat Central Nervous System ES Hauck, S Zou, K Scarfo, MH Nantz and JG Hecker.  Molecular Therapy 2008, 16, 1857-1864.

Patents & Licenses:

• P1. MH Nantz, MJ Bennett and RW Malone
• Cationic Transport Reagents
• Filed: September 30, 1994; Issued: June 18, 1996
• United States Patent No. 5,527,928
• Patent licensed to Promega Corporation, Madison, WI.
• P2. MH Nantz, MJ Bennett and RW Malone
• Cationic Transport Reagents (Divisional)
• Filed: May 16, 1996; Issued: April 28, 1998
• United States Patent No. 5,744,625
• Patent licensed to Promega Corporation, Madison, WI.
• P3. MH Nantz, MJ Bennett, RP Balasubramaniam, AM Aberle and RW Malone
• Polyfunctional Cationic Cytofectins, Formulations and Methods for Generating Active Cytofectin–Polynucleotide Transfection Complexes
• Filed: September 17, 1996; Issued: October 20, 1998
• United States Patent No. 5,824,812
• Patent licensed to Promega Corporation, Madison, WI.
• P4. MH Nantz, MJ Bennett and RP Balasubramaniam
• Polyfunctional Cationic Cytofectins.
• Filed: September 27, 1995; Issued: February 9, 1999
• United States Patent No. 5,869,715
• Patent licensed to Promega Corporation, Madison, WI.
• P5. MH Nantz, MJ Bennett and RW Malone
• Cationic Transport Reagents (CIP)
• Filed: September 15, 1995; Issued: April 6, 1999
• United States Patent No. 5,892,071
• Patent licensed to Promega Corporation, Madison, WI.
• P6. MH Nantz, MJ Bennett, RP Balasubramaniam, AM Aberle and RW Malone
• Formulations and Methods for Generating Active Cytofectin–Polynucleotide Transfection Complexes.
• Filed: July 15, 1996; Issued: July 20, 1999
• United States Patent No. 5,925,623
• Patent licensed to Promega Corporation, Madison, WI.
• P7. MH Nantz and AM Aberle
• Pentaerythritol Lipid Derivatives
• Filed: April 3, 1998; Issued: March 28, 2000
• United States Patent No. 6,043,390
• 16
• P8. MH Nantz and J Zhu
• Ortho Ester Lipids
• Filed: October 7, 1999; Issued: March 13, 2001
• United States Patent No. 6,200,599
• P9. MH Nantz and AM Aberle
• Pentaerythritol Lipid Derivatives (Divisional)
• Filed: March 27, 2000; Issued: November 13, 2001
• United States Patent No. 6,316,421
• P10. MJ Bennett, MH Nantz and SS Rothman
• Method for Nucleic Acid Transfection of Cells
• Filed: January 20, 2000; Issued: April 16, 2002
• United States Patent No. 6,372,722
• P11. MJ Bennett, SS Rothman and MH Nantz
• Method for Nucleic Acid Transfection of Cells (Divisional)
• Filed: January 18, 2001; Issued: September 23, 2003
• United States Patent No. 6,624,149
• PENDING EJ Niedzinski, MH Nantz, MJ Bennett and M Lizarzaburu
• Polyamine-Mediated Transfection
• Filed: May 31, 2002
• United States Patent Application No. 60/385,234
• PENDING J Wu and MH Nantz
• Extracellular Superoxide Dismutase (EC-SOD) Gene Delivery To Prevent Oxidative Injury
• Filed: WO 2005069938 (58 pp.); UC Case No. 2003-483-1
• United States Patent Application No. pending
• PENDING FA Gorin and MH Nantz
• Novel Bioactive Amino Acid and Peptide Conjugates of Amiloride
• Filed: WO 2005073247 (122 pp.); UC Case No. 2004-265-1
• United States Patent Application No. pending
• PENDING JG Hecker and MH Nantz
• Novel Methods and Models for Rapid, Widespread Delivery of Genetic Material to the CNS Using Non-Viral Cationic Lipid-Mediated Vectors
• Filed: December 14, 2006 (Ref P-3141PCT)
• Priority from: US Provisional Application 60/751,470, Filed December 15, 2005
• PENDING FA Gorin and MH Nantz
• Inhibitors of Intracellular Urokinase Plasminogen Activator and Methods of Use Thereof
• Filed: August 3, 2007 WO (xx pp.); UC Case No. 2007-265-1
• Provisional United States Patent Application No. 60/953,796