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Kyung A. Kang, Ph.D.

by Wittliff,James L. last modified Oct 04, 2013 02:37 PM

Professor & Graduate Program Director of Chemical Engineering

KangEmail Kyung Kang
Phone Number: (502) 852-2094
Fax Number: (502) 852-6355
Address: Department of Chemical Engineering

Website:  https://louisville.edu/speed/faculty/kang

Speed School of Engineering
Ernst Hall 312 (Office)
Ernst Hall 303  A&B( Lab)
University of Louisville
Louisville, KY 40292
Ph. D. 1991, University of California, Davis

 

Investigators:

    • Chadni Bhikna – High School Student
    • Janice Kim – High School Student
    • Brian Lam - High School Student
    • Srinivas Beeram – Postdoctoral Fellow

     

    Research Interests:

     Nano-Biotechnology:
    • Nano-metal particles for Fluorescence Enhancement
    • Nanoparticles for Optical Contrast in Optical Mammography
    • Application of Nano-magnetic Particles for Tumor Specific Hyperthermia

     

    Photonics I – Real-time, Micro-Scale, Immuno Optical, Multimarker, Biosensing System:
    • Biosensing systems for disease diaganosis/monitoring/prognosis – Anticoagulants (Protein C, Protein S, Antithrombin III, Plasminogen), Factor V Leiden), Cardiac Markers (Cardiac Troponin T/I, CRP, BNP, Myoglobin)

     

    Photonics II – Bio-system Characterization and Imaging
    • NIR Spectroscopy (Experimental, Clinical, and Theoretical):  Algorithm Development for Absolute Optical Parameters; Characterization of Oxygen Saturation State in various Tissue; Frequency Response Analysis Theory for Optical Pulse Testing; Algorithm Development for Clinical Imaging
    • Application: Oxygen Saturation Measurement; Breast Tumor Localization; Hemotoma Detection; Blood Flow Measurement; Deep Vein Thrombosis Detection
    • Multi-Spectral Image Analysis for Skin Cancer Detection.

     

    Bio-Separation - Bioseparation (Experimental/Theoretical):
    •  Ion Exchange Chromatography; Various Affinity Chromatography Separation; Purification of Protein C (Anti-coagulant) from Blood Plasma.

     

    Numerical Analysis and Computer Simulation for Bio-Transport Systems
    • Co-Developer of a probabilistic/numerical technique, the B-W-K Technique.
    • Oxygen Transport to Tissue
    • Heat Transfer during Cancer Hyperthermia
    • Photon Transfer in highly scattering media

     

    Selected Publications:

      1. Wang, J., Nantz, M.H., Achilefu, S., and Kang, K.A., “FRET-Like Fluorophore-Nanoparticle Complex for Highly Specific Cancer Localization,” Advances in Experimental Medicine and Biology, Vol. 662, P. 407-414, 2010.
      2. Sanapala, K.K., Hewaparakrama, K., and Kang, K.A., “Effect of AEM Energy Applicator Configuration on Magnetic Nanoparticle Mediated Hyperthermia for Breast Cancer,” Advances in Experimental Medicine and Biology, Vol. 701  (LaManna JC,  Puchowicz MA, Xu K, Harrison DK, Bruley DF (Eds.) P. 143-147, 2011.
      3. Wang, J., O’Toole, M.G., Massey, A., Biswas, S., Nantz, M., Achilefu, S., and Kang, K.A., “Highly specific, NIR fluorescent contrast agent with emission controlled by gold nanoparticle,” Advances in Experimental Medicine and Biology, Vol. 701,  P. 149-154, 2011.
      4. Wang, J., Achilefu, S., Nantz, M. and Kang, K.A., “Gold nanoparticle-fluorophore complex for conditionally fluorescing signal mediator,” Analytica Chimica Acta., Vol. 695, p.96–104, 2011
      5. Kang, K.A., Wang, J., Jasinski, J., and Achilefu, S., “Fluorescence Manipulation by Gold Nanoparticles: From Complete Quenching to Enhancement,” Journal of NanoBiotech. Vol. 9 p.16-28, 2011
      6. Kang, K.A., Wang, J., O’Toole, M.G., Nantz, M., Moore, J.D., Laulhe, S., and Achilefu, S., “Sensitivity Enhancement of NIR Fluorescence Contrast Agent Utilizing Gold Nanoparticle,” Advances in Experimental Medicine and Biology, Vol. 737, p. 285-291, 2012
      7. Kang, K.A., “Mapping PVS by Molecular Imaging with Contrast Agents,” In:The Primo Vascular System: Its Role in Cancer and Regeneration, p. 227-234, 2012.
      8. Soh K.-S., Kang, K.A., and Harrison, D.R. “The Primo Vascular System: Its Role in Cancer and Regeneration,” Springer Publisher, 2012
      9. Wang, J., Moore, J.D., Laulhe, S., and Achilefu, S., and Kang, K.A., ”Fluorophore-gold nanoparticle complex for sensitive optical biosensing and imaging,” Nanotechnology, Vol. 23, 095501, 2012
      10. Wang, S, Liu, M.C., and Kang, K.A., “Magnetic nanoparticle/heat-sensitive polymer complex for hyperthermia and sustained drug release,” Advances in Experimental Medicine and Biology, Vol. 765, p. 315-321, 2012
      11. Wang, J., Wheeler, D., Zhang, J.Z., Achilefu, S., and Kang, K.A., “NIR fluorophore-gold nanosphere complex for cancer enzyme triggered detection and hyperthermia,” Advances in Experimental Medicine and Biology, Vol. 765, p. 323-328, 2012
      12. Li, L.Z., Nioka S., and Kang, K.A., “Dedication: Britton Chance, M.D., Ph.D., D.Sc.” Advances in Experimental Medicine and Biology Vol. 765, p. v-xiv, 2012.
      13. Kang, K.A., Maldonado C., Perez-Aradia G., An P.,  and Soh, K.-S., “Primo Vascular System and Its Role in Cancer,” Advances in Experimental Medicine and Biology (Eds. S. Van Huffel, G. Naulaers, A. Caicedo, D. F. Bruley, D. K. Harrison), Vol . 789, p.289-296, 2013
      14. Soh, K.S., Kang, K.A., and Ryu, Y.H, “50 years of Bong-Han Theory and 10 years of Primo Vascular System,” Evidence Based Complementary and Alternative Medicine, Vol. 2013 , 587827, 2013
      15. Kang, K.A., “A Half Century Gap between Bonghan System and Primo Vascular System,” Journal of Acupuncture and Meridian Studies,” (2013), http://dx.doi.org/10.1016/j.jams.2013.07.004
      16. Kang, K.A., ”Britton Chance’s Lab and Thereafter: From NIR Spectroscopy To Molecular Sensing via Nanotechnology,” Journal of Optical Sciences, accepted

       

      Patents & Licenses:

       Patents granted

      1. U.S. Patent No. 7,871,573 B2 Enhancement of Sensitivity of Fluorophore Mediated Biosensing and Bioimaging. Issued on January 18, 2011  
      2. U.S. Patent No. 7,883,900 B2 Enhancement of Sensitivity of Fluorophore Mediated Biosensing and Bioimaging: Divisional patent, Issued on February 8, 2011
      3. Australian Patent No. 2009246822, Cancer Site Specific Fluorescence Marking and Contrast Marker for Same; Granted Aug. 16, 2012
      4. ALLOWED to ISSUE: Fiber Optic Multi-Cardiac Marker Biosensing System for Rapid Coronary Heart Disease Diagnosis; Non-provisional patent application no. 11/355,467, filed February 16, 2006.  Received Notice of Allowance May 2013.


      Patents Pending:

      1. ULRF 04031 – Near Real Time Biosensor for the Factor V Leiden Diagnosis. Non-provisional patent application no. 11/891,452 filed August 10, 2007; Status:  April 2009: Received notice of publication
      2. ULRF 07074 – Cancer Site Specific Fluorescence Marking and Contrast Marker for Same; Priority Filing: PCT/US2009/TBA; filed March 31, 2009. * U.S. Patent Application ser. no. 12/935,336; Cancer Site Specific Fluorescence Marking and Contrast Marker for Same; filed March 31, 2009.
      3. ULRF 11063; Aptamer-Conjugated Gold Nanoparticles; U.S. Provisional Patent Application 61/492,683; filed June 2, 2011.  Aptamer-Conjugated Gold Nanoparticles, inventors Paula J. Bates, Mohammad Tariq Malik, Kyung A. Kang

       

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