Email Grant Taylor
Phone Number: (502) 852-5970 (Office)
Fax Number: (502) 852-8149
Address:
Department of Chemistry
University of Louisville
Louisville, KY 40292
Ph. D. 1963, Wayne State University

Additional Appointments:

• Professor of Organic Chemistry, University of Louisville

Research Interests:

• Synthesis of glucosyl transferase inhibitors
• Oligosaccharide synthesis and conformation
• carbohydrate-protein interactions
• Oral bacterial adhesions
• Sucrose chemistry

• Diacylperoxide thermolysis mechanisms
• Structural probes of radical pair and ion pair mechanisms
• Molecule-assisted homolysis and heterolysis
• SN2/SET induction of O-O bond cleavage

• Strained cyclic diallenes
• Thermal and catalyzed allene oligomerization
• Diastereomeric carbenoid reactions
• Enantioselective recognition

• Professor Taylor’s past work on peroxide chemistry enabled their use as structural probes of radical and ionic reactions on models of nucleic acids.  His work in carbohydrate chemistry yielded, with R. J. Doyle (deceased), the discovery of agents having prophylactic activity versus dental caries.  Recently, collaborative work with W. M. Pierce has led to the discovery of several small molecules active versus bone diseases in animal models (US Patent no. 7,196,220). He is, with Dr. Pierce (President and CEO), a cofounder of Pradama, Inc. a specialty pharmaceutical company focused on the development and commercialization of products to treat bone diseases.  Professor Taylor has received the Outstanding Performance Award for Academic Management and is a Fellow of the American Association for the Advancement of Science.

Selected Publications:

1. Synthesis and Conformational Analysis of the Forssman Pentasaccharide and Di-, Tri-, and Tetrasaccharide Fragments G. Magnusson, U. Nilsson, A. K. Ray, and K. G. Taylor in Carbohydrate Antigens, ACS Symposium Series, 519, P. J. Goregg, A. A. Lindberg, Eds., Am. Chem. Soc., Washington, 1993
   
2. Essential amino acids in the combining site of the glucan-binding lectin of Streptococcus sobrinusS. Singh, K. G. Taylor, R. J. Doyle Carbohydr. Res., 1993, 244, 137-147
   
3. Acquisition of manganous ions by Streptococcus sobrinus P. Bauer, C. Trapp, D. Drake, K. G. Taylor, R. J. Doyle J. Bacteriol., 1993, 175, 819-825. Infection and Immunity,  1992, 3807 3813
   
4. New Inhibitors of the Glucan-Binding Lectin of Streptococcus sobrinus M. Mehlbauer, K. G. Taylor, E. M. Sonnenfeld, B. Asemani, and R. J. Doyle New Perspectives on Streptococci and Streptococcal Infections, Zbl. Bakt. Suppl. 22, G. Orefici, Ed., Gustav Fischer, New York, 1992, pp.146-148
   
5. Amine-Induced Reactions of Diacyl Peroxides S. Srinivas and K. G. TaylorJ. Org. Chem. 1990, 55, 1779-1785
   

Patents & Licenses:

1. “Bone targeting compounds for delivering agents to the bone for interaction therewith.” W. M. Pierce, L. Waite, K. G. Taylor; US Patent no. 7,196,220 (2007).