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K. Grant Taylor, Ph.D.

by Wittliff,James L. last modified Oct 04, 2013 02:43 PM

Professor of Chemistry

TaylorEmail Grant Taylor
Phone Number: (502) 852-5970 (Office)
Fax Number: (502) 852-8149
Address:
Department of Chemistry
University of Louisville
Louisville, KY 40292
Ph. D. 1963, Wayne State University

 

Additional Appointments:

  • Professor of Organic Chemistry, University of Louisville

 

Research Interests:

CARBOHYDRATE CHEMISTRY

 

  • Synthesis of glucosyl transferase inhibitors
  • Oligosaccharide synthesis and conformation
  • carbohydrate-protein interactions
  • Oral bacterial adhesions
  • Sucrose chemistry
 
FREE RADICAL CHEMISTRY

 

  • Diacylperoxide thermolysis mechanisms
  • Structural probes of radical pair and ion pair mechanisms
  • Molecule-assisted homolysis and heterolysis
  • SN2/SET induction of O-O bond cleavage
 
CARBENES, CARBENOIDS AND STRAINED RINGS

 

  • Strained cyclic diallenes
  • Thermal and catalyzed allene oligomerization
  • Diastereomeric carbenoid reactions
  • Enantioselective recognition

 

  • Professor Taylor’s past work on peroxide chemistry enabled their use as structural probes of radical and ionic reactions on models of nucleic acids.  His work in carbohydrate chemistry yielded, with R. J. Doyle (deceased), the discovery of agents having prophylactic activity versus dental caries.  Recently, collaborative work with W. M. Pierce has led to the discovery of several small molecules active versus bone diseases in animal models (US Patent no. 7,196,220). He is, with Dr. Pierce (President and CEO), a cofounder of Pradama, Inc. a specialty pharmaceutical company focused on the development and commercialization of products to treat bone diseases.  Professor Taylor has received the Outstanding Performance Award for Academic Management and is a Fellow of the American Association for the Advancement of Science.

  

Patents & Licenses:

  1. International Patent Application No. PCT/US2013/032650 (In the Name of: The Regents of the University of California) "NOVEL OXYSTEROL ANALOGUE, OXY149, INDUCES OSTEOGENESIS AND HEDGEHOG SIGNALING AND INHIBITS ADIPOGENESIS" 09/2013
  2. Provisional Application for Patent; Serial No. 61/643,776 (In the Name of: The Regents of the University of California) "NOVEL OXYSTEROL ANALOGS LINKED TO BONE TARGETING MOIETY, INCLUDING OXY149, ARE SYSTEMICALLY DELIVERED TO BONE AND INDUCE OSTEOGENESIS AND HEDGEHOG SIGNALING AND INHIBIT ADIPOGENESIS" 10/2012
  3. Patent Award: No. US 7,196,220 (With William Pierce and Leonard Waite) "BONE-TARGETING COMPOUNDS FOR DELIVERING AGENTS TO THE BONE AND FOR INTERACTION THEREWITH" 12/2011

 

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