You are here: Home Faculty Pages Gerald B. (GB) Hammond, Ph.D.

Gerald B. (GB) Hammond, Ph.D.

by Wittliff,James L. last modified Oct 04, 2013 02:17 PM

Professor of Chemistry & University Scholar


 Email GB Hammond
Phone Number: (502) 852-5998 (Office)
Fax Number: (502) 852-3899
Address: Department of Chemistry; University of Louisville; Louisville, KY 40292
Ph. D. 1985 University of Birmingham, England


Additional Appointments: 

  • Program Director, Chemistry Division, National Science Foundation, Arlington, Virginia


Research Interests:

  • Synthetic methods development using fluorine
  • Targeting neglected diseases and cancer using bioinspired compounds
  • Streamlining chemical synthesis using supported organic phases



    • Bo Xu
    • Elisha Otome
    • Deepika Malhotra
    • Manish Kumar
    • S. Liang
    • Junbin Han
    • Andrew Flach
    • Z. Lu 


    Selected Publications:

      1.  “Gold-Catalyzed Addition of N‑Hydroxy Heterocycles to Alkynes and Subsequent 3,3-Sigmatropic Rearrangement” M. Kumar, M. Scobie, M. S. Mashuta, G. B. Hammond, B. Xu Org. Lett 2013 15, 724–727.
      2. “Physangulidine A, the New Withanolide from Physalis angulata, Perturbs the Cell Cycle and Induces Cell Death by Apoptosis in Prostate Cancer Cells" E. Reyes-Reyes, Z. Jin, A. Vaisberg, G. B. Hammond, P. J. Bates J. Nat. Prod. 2013, 76, 2–7.
      3. “Gold Catalyzed Annulation of 2- Alkynyl Benzaldehyde with Vinyl Ether: Synthesis of Substituted 3,4-Dihydronapthalenyl Ketones, 1H-Isochromenes, and Bicyclo[2.2.2]octanyl Ketones via a Gold-Benzopyrylium Intermediate" M. Deepika, M. Mashuta, G. B. Hammond, L. Liu, Chem. Eur. J. 2013 19, 4043-4050
      4. “Synthesis of Cyclic -Aminophosphonates through Copper Catalyzed Enamine Activation J. Han, R. S. Paton, B. Xu, G. B. Hammond Synthesis 2013 45, 463-470.
      5. “Transition Metal Sponsored Fluorination, Difluoromethylation and Trifluoromethylation” Z. Jin, B. Xu, G. B. Hammond Aldrichimica Acta 2012 45, 67- 83.
      6. "Stereoselective Synthesis of Monofluoroalkyl -Unsaturated Ketones From Allenyl Carbinol Esters Mediated by Gold and Selectfluor" Z. Jin, R. Hidinger, B. Xu, G.B. Hammond . J. Org. Chem. 2012 77, 7725–7729.
      7. “Replacement of BF4- by PF6-Makes Selectfluor Greener” Z. Jin, B. Xu, G. B. Hammond, S. G. DiMagno J. Fluorine Chem. 2012 143, 226-230.
      8. “Ligand Effects and Ligand Design in Homogeneous Gold Catalysis” W. Wang, G. B. Hammond, B. Xu J. Am. Chem. Soc. 2012 134, 5697-5705.
      9. “Physangulidines A, B and C: Three New Antiproliferative Withanolides from Physalis angulata L”  Z. Jin, M. Mashuta, N. Stolowich, W. J. Lewis, A. J. Vaisberg, N. S. Stivers, P. J. Bates, G. B. Hammond. Org. Lett 2012 14, 1230-1233.
      10. “Recent Advances on the Isolation and Reactivity of Organogold Complexes” L. Liu and G. B. Hammond Chem. Soc. Rev. 2012, 41, 3129 - 3139.
      11. “Gold-Catalyzed Intramolecular Oxygen Transfer Reactions of 2-Alkynyl-1,5-Diketones or 2-Alkynyl-5-Ketoesters. Scope Expansion and Mechanistic Investigations on A Novel [4+2] Cycloaddition” L. Liu, D. Malhotra, Z. Jin, R. S. Paton, K. N. Houk, and G. B. Hammond Chem. Eur. J. 2011 17, 10690-10699.
      12. “Synthesis Of Fluorohydrins Through Electrophilic Fluorination Of Allyl Silanes” B. Xu, W. Wang, G. B. Hammond Synthesis 2011, 2383-2386.
      13. “Library-Friendly Synthesis Of Fluorinated Ketones Through Functionalized Hydration Of Alkynes And Investigation Of The Reaction Mechanism” B. Xu, W. Wang, G. B. Hammond J. Fluorine Chem. 2011 132, 804-810.
      14. “Synthesis of -CN and -CF3 N-Heterocycles through Tandem Nucleophilic Additions” J. Han, B. Xu, G.B. Hammond Org. Lett. 2011 13, 3450-3453.
      15. “Cytotoxic and Antiinfective Phenolic Compounds Isolated from Mikania decora (Compositae) and Cremastosperma microcarpum (Annonaceae)” J. C. Aponte, Z. Jin, A. J. Vaisberg, D. Castillo, E. Málaga, W. H. Lewis, M. Sauvain, R. H. Gilman, G. B. Hammond Planta Medica 2011, 77, 1597-1599.
      16. “Construction of Cyclic Enones via Gold-Catalyzed Oxygen Transfer Reactions” L. Liu, B. Xu, G. B. Hammond Beilstein J. Org. Chem. 2011, 7, 606-614.
      17. “Copper Mediated Oxidation of Amides into Imides by Selectfluor” Z. Jin, B. Xu, G. B. Hammond Tetrahedron Lett 2011 52, 1956-1959.
      18. “Synthetic Evolutions in the Nucleophilic Addition to Alkynes” B. Xu, W. Wang, L. Liu, J. Han, Z. Jin and G. B. Hammond J. Organomet. Chem. 2011 696, 269-276.
      19. “The [4+2], not [2+2], Mechanism Occurs in the Gold-Catalyzed Intramolecular Oxygen Transfer Reaction of 2-Alkynyl-1,5-Diketones” L. Liu, D. Malhotra, R. S. Paton, K. N. Houk, and G. B. Hammond Angew. Chem. Int. Ed. 2010 49, 9132 – 9135.
      20. “Tandem Michael Addition/Aldol Reaction of Allenic Ketones with Alkyl Vinyl Ketones: Versatile Synthesis of 2-Alkynyl-1,5-Diketones, 4-Alkynyl-3-Hydroxycyclohexones and 4-Alkynylcyclohexenones” D. Malhotra, L. Liu, G. B. Hammond Eur. J. Org. Chem. 2010 6855-6862.
      21. “Gold-Catalyzed Cascade Annulations of 2-(Ynol)Aryl Aldehydes: Facile Synthesis of Benzochromanes and Benzobicyclo[n.3.1]acetals” L. Liu and G. B. Hammond Org. Lett. 2010 12, 4640-4643.
      22. “Fluorine-enabled cationic gold catalysis: Functionalized hydration of alkynes” W. Wang, J. Jasinski, B. Xu, G. B. Hammond Angew. Chem. Int. Ed. 2010 49, 7247-7252.
      23. “Transformative Syntheses of Fluorinated Heterocyclics Using a Difluorohomopropargylic Template” S. Arimitsu and G. B. Hammond Chimica Oggi/Chemistry Today 2010 28, 20-22.
      24. “From Vinylogation to Alkynylogation: Extending the Reactivity of Enolates” B. Xu and G. B. Hammond Synlett Account 2010 1442-1454.
      25. “Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides” S. Arimitsu and G. B. Hammond Beilstein J. Org. Chem. 2010 6, No. 48.
      26. “Trypanoside, Anti-Tuberculosis, Leishmanicidal and Cytotoxic Activities of Tetrahydrobenzothienopyrimidines” J. C. Aponte, A. J. Vaisberg, D. Castillo, G. Gonzalez, J. Arevalo, M. Quiliano, M. Zimic, M. Verástegui, E. Málaga, R. H. Gilman, J. M. Bustamante, R. Tarleton, Y. Wang, S.Franzblau, G. Pauli, M. Sauvain, G. B. Hammond Bioorg. Med. Chem. 2010 18, 2880–2886.
      27. “Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)” J. C. Aponte, H. Yang, A. J. Vaisberg, D. Castillo, E. Málaga, M. Verástegui, L. K. Casson,  N. Stivers, P. J. Bates, R. Rojas, I. Fernandez, W. H. Lewis, M. Sauvain, R. H. Gilman, G. B. Hammond Planta Medica 2010, 76, 705-707.
      28. “In Vitro and In Vivo Anti-Leishmania Activity of Polysubstituted Synthetic Chalcones” J. C. Aponte, D. Castillo, Y. Estevez, G. Gonzalez, J. Arevalo, G. B. Hammond, M. Sauvain Bioorg. Med. Chem. Lett. 2010, 20, 100-103.
      29. “Highly efficient Cu(I)-catalyzed synthesis of N-heterocycles through a cyclization-triggered addition of alkynes” J. Han, B. Xu. G. B. Hammond J. Am. Chem. Soc. 2010, 132, 916–917. This article was featured in Synform 2010, 4, A37.
      30. “Green Synthesis of Vicinal Dithioethers and Alkenyl Thioethers from the Reaction of Alkynes and Thiols in Water” Z. Jin, B. Xu, G. B. Hammond Eur. J. Org. Chem. 2010 168-173.

      Patents & Licenses:

      1.  “Compositions and methods for modulating DNMT1 inhibitor activity” F. Salipur, P. J. Bates, E. Merit Reyes-Reyes, B. Xu, G.B. Hammond. U.S>/PCT 61/698,403. Filing date: September 7, 2012.
      2. “Substituted alkyne derivatives as anticancer agents” U.S. Patent 8,207,381. Filing date: June 26, 2012. Inventors: G. B. Hammond, B. Xu, P. J. Bates. 
      3. Institut de Recherche pour le Développement, Marseille, France, a branch from the French government, licensed our provisional patent  61/ 089,231 for the developing of chalcones targeting Leishmaniasis on October 2009.
      4. Transmed Oncology, Ltd. Phoenix, AZ licensed our provisional patent PCT/US 2008053214 for the developing of anticancer therapies on December 2008.
      5. "Methods of synthesis and purification by use of a solid support" PCT/U.S. U.S. Patent Application No. 12/852,763. Filing date: August 09, 2010. Inventors: B. Xu and G. B. Hammond.
      6. “Synthesis of stable organogold compounds and methods of use thereof” PCT/US2009/065488. Filing date: November 23, 2009. Inventors: G. B. Hammond, P. J. Bates, A. J. Vaisberg, L. Liu, B. Xu.
      7. “Compounds, Their Syntheses, And Their Uses” PCT/US09/53856. Filing date: August 14, 2009. Inventors: G. B. Hammond, J. C. Aponte, M. Sauvain, A. J. Vaisberg, R. H. Gilman.


      Document Actions
      Personal tools