Email GB Hammond
Phone Number: (502) 852-5998 (Office)
Fax Number: (502) 852-3899
Address: Department of Chemistry; University of Louisville; Louisville, KY 40292
Ph. D. 1985 University of Birmingham, England

Additional Appointments: 

• Program Director, Chemistry Division, National Science Foundation, Arlington, Virginia

Research Interests:

• Synthetic methods development using fluorine
• Targeting neglected diseases and cancer using bioinspired compounds
• Streamlining chemical synthesis using supported organic phases

Investigators:

Research Assistant Professor: Xu Bo
Graduate students: Junbin Han, Deepika Malhotra, Manish Kumar, Elisha Otome, Shengzong Liang
Undergraduate students: Mallory A Durham, Tony Montgomery

Selected Publications:

1.  “Ligand Effects and Ligand Design in Homogeneous Gold Catalysis” W. Wang, G. B. Hammond, B. Xu J. Am. Chem. Soc. 2012 134, 5697-5705.
2. “Physangulidines A, B and C: Three New Antiproliferative Withanolides from Physalis angulata L”  Z. Jin, M. Mashuta, N. Stolowich, W. J. Lewis, A. J. Vaisberg, N. S. Stivers, P. J. Bates, G. B. Hammond. Org. Lett 2012 14, 1230-1233.
3. “Recent Advances on the Isolation and Reactivity of Organogold Complexes” L. Liu and G. B. Hammond Chem. Soc. Rev. 2012, 41, 3129 - 3139.
4. “Gold-Catalyzed Intramolecular Oxygen Transfer Reactions of 2-Alkynyl-1,5-Diketones or 2-Alkynyl-5-Ketoesters. Scope Expansion and Mechanistic Investigations on A Novel [4+2] Cycloaddition” L. Liu, D. Malhotra, Z. Jin, R. S. Paton, K. N. Houk, and G. B. Hammond Chem. Eur. J. 2011 17, 10690-10699.
5. “Synthesis Of Fluorohydrins Through Electrophilic Fluorination Of Allyl Silanes” B. Xu, W. Wang, G. B. Hammond Synthesis 2011, 2383-2386.
6. “Library-Friendly Synthesis Of Fluorinated Ketones Through Functionalized Hydration Of Alkynes And Investigation Of The Reaction Mechanism” B. Xu, W. Wang, G. B. Hammond J. Fluorine Chem. 2011 132, 804-810.
7. “Synthesis of a-CN and a-CF3 N-Heterocycles through Tandem Nucleophilic Additions” J. Han, B. Xu, G.B. Hammond Org. Lett. 2011 13, 3450-3453.
8. “Cytotoxic and Antiinfective Phenolic Compounds Isolated from Mikania decora (Compositae) and Cremastosperma microcarpum (Annonaceae)” J. C. Aponte, Z. Jin, A. J. Vaisberg, D. Castillo, E. Málaga, W. H. Lewis, M. Sauvain, R. H. Gilman, G. B. Hammond Planta Medica 2011, 77, 1597-1599.
9. “Synthesis of a-CN and a-CF3 N-Heterocycles through Tandem Nucleophilic Additions” J. Han, B. Xu, G.B. Hammond Org. Lett. 2011 13, 3450-3453.
10. “The [4+2], not [2+2], Mechanism Occurs in the Gold-Catalyzed Intramolecular Oxygen Transfer Reaction of 2-Alkynyl-1,5-Diketones” L. Liu, D. Malhotra, R. S. Paton, K. N. Houk, and G. B. Hammond Angew. Chem. Int. Ed. 2010, 49, 9132 – 9135.
11. “Gold-Catalyzed Cascade Annulations of 2-(Ynol)Aryl Aldehydes: Facile Synthesis of Benzochromanes and Benzobicyclo[n.3.1]acetals” L. Liu and G. B. Hammond Org. Lett. 2010 12, 4640-4643.
12. “Fluorine-enabled cationic gold catalysis: Functionalized hydration of alkynes” W. Wang, B. Xu, G. B. Hammond Angew. Chem. Int. Ed. 2010 49, 7247-7252.
13. “From Vinylogation to Alkynylogation: Extending the Reactivity of Enolates” B. Xu and G. B. Hammond Synlett Account 2010 1442-1454.
14. “Trypanoside, Anti-Tuberculosis, Leishmanicidal and Cytotoxic Activities of Tetrahydrobenzothienopyrimidines” J. C. Aponte, A. J. Vaisberg, D. Castillo, G. Gonzalez, J. Arevalo, M. Quiliano, M. Zimic, M. Verástegui, E. Málaga, R. H. Gilman, J. M. Bustamante, R. Tarleton, Y. Wang, S.Franzblau, G. Pauli, M. Sauvain, G. B. Hammond Bioorg. Med. Chem. 2010 18, 2880–2886.
15. “Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)” J. C. Aponte, H. Yang, A. J. Vaisberg, D. Castillo, E. Málaga, M. Verástegui, L. K. Casson,  N. Stivers, P. J. Bates, R. Rojas, I. Fernandez, W. H. Lewis, M. Sauvain, R. H. Gilman, G. B. Hammond Planta Medica 2010, 76, 705-707.
16. “Highly efficient Cu(I)-catalyzed synthesis of N-heterocycles through a cyclization-triggered addition of alkynes” J. Han, B. Xu. G. B. Hammond J. Am. Chem. Soc. 2010, 132, 916–917. This article was featured in Synform 2010, 4, A37.
17. “A Multipronged Approach to the Study of Peruvian Ethnomedicinal Plants. A Legacy of the ICBG-Peru Project” J. C. Aponte, A. J. Vaisberg, R. Rojas, M. Sauvain, W. H. Lewis, G. Lamas, C. Sarasara, R. H. Gilman, G. B. Hammond. J. Nat. Prod. 2009, 72, 524-526.
18. “Highly Regioselective Fluorination And Iodination Of Alkynyl Enolates” H. Yang, B. Xu, G. B. Hammond Org. Lett. 2008, 10, 5589–5591.
19. “Synthesis And Structural Characterization Of Stable Organogold(I) Compounds. Evidence For The Mechanism Of Gold-Catalyzed Cyclizations” L. Liu, B. Xu, M. S. Mashuta, G. B. Hammond J. Am. Chem. Soc. 2008, 130, 17642–17643.
20. “Synthesis, Cytototoxic And Anti-Trypanosoma Cruzi Activity Of New Chalcones” J. C. Aponte, M. Verástegui,  E. Málaga, M. Zimic, M. Quiliano, A. J. Vaisberg, R. H. Gilman, G. B. Hammond J. Med. Chem. 2008, 51, 6230-6234.
21. “Isolation Of Cytotoxic Metabolites From Targeted Peruvian Amazonian Medicinal Plants” J. C. Aponte, A. J. Vaisberg, R. Rojas, L. Caviedes, W. H. Lewis, G. Lamas, C. Sarasara, R. H. Gilman, G. B. Hammond J. Nat. Prod. 2008, 71, 102-105.
22. “Thermodynamically Favored Aldol Reaction Of Propargyl Or Allenyl Esters: Regioselective Synthesis Of Carbinol Allenoates” B. Xu G. B. Hammond, Angew. Chem. Int. Ed. 2008, 47, 689-692.
23. “Crystallographic Characterization of Difluoropropargylindium Bromide, a Reactive Fluoroorganometallic Reagent" B. Xu, M. S. Mashuta, G. B. Hammond Angew. Chem. Int. Ed. 2006 45, 7265-7267.
24. “Difluoroallenyl Bromide as a Wide-Ranging Difluoromethylene Cation Equivalent: SN2 Substitution of Difluoropropargyl Bromide through Sequential SE2' and SN2' Reactions" B. Xu. G.B. Hammond Angew. Chem. Int. Ed. 2005, 44, 7404-7407.

Distinctive Scholarship Activities:

1. Chair, Award Selection Committee, American Chemical Society.
2. Member NIH Special Review Emphasis Panel: Kirchstein NRSA Postdoctoral Fellowship.
3. Invited Member, Institute of Molecular Diversity and Drug Design, University of Louisville, since 2004.
4. Chair of the Division of Fluorine Chemistry of the American Chemical Society for 2004. Vice-Chair for Programs of the Division (2001-2003).
5. Editorial Board Member of the Journal of Fluorine Chemistry since 2001.

Awards Received:

• 2007    Research Fellow, Generalitat Valenciana, Spain
• 2004    University Scholar, University of Louisville
• 2002    Fulbright Scholar, U.S. State Department
• 2001     Camille and Henry Dreyfus Scholar-Fellow, Camille and Henry Dreyfus Foundation
• 2009    Honored during Faculty Excellence Recognition Ceremony, University of Louisville (licensing of anticancer compound).
  

Patents & Licenses:

1.  "Methods of synthesis and purification by use of a solid support" U.S. Provisional Patent Application 61234005. Filing date: August 14, 2009. Inventors: B. Xu and G. B. Hammond.
2. “Synthesis of stable organogold compounds and methods of use thereof” PCT/US2009/065488. Filing date: November 23, 2009. Inventors: G. B. Hammond, P. J. Bates, A. J. Vaisberg, L. Liu, B. Xu.
3. “Compounds, Their Syntheses, And Their Uses” PCT/US09/53856. Filing date: August 14, 2009. Inventors: G. B. Hammond, J. C. Aponte, M. Sauvain, R. H. Gilman.Transmed Oncology, Ltd. Phoenix, AZ licensed our provisional patent 12/027,154 for developing of anticancer therapies on December 2008.
4. “Synthesis of stable organogold compounds and methods of use thereof” U. S. Provisional Patent Application 61/118,002.  Filing date: November 26, 2008. Inventors: B. Xu, L. Liu, P. J. Bates, A. J. Vaisberg, G. B. Hammond.
5. “Compounds, Their Syntheses, And Their Uses” U. S. Provisional Patent Application No. 61/ 089,231. Filing date: August 15, 2008. Inventors: G. B. Hammond, J. C. Aponte, M. Sauvain, R. H. Gilman.
6. “Therapeutic Compound” U.S. Provisional Patent Application No. 12/027,154. Filing date: February 6, 2008. Docket: 17541.060US1. Inventors: G. B. Hammond, B. Xu, P. J. Bates.