Paula M. Chilton, Ph.D.
Assistant Professor, Dept. of Microbiology & Immunology
Ph.D. University of Louisville, 1996
B.S. Western Kentucky University 1991
Research Interests
- Effects of low-toxicity TLR-based adjuvants on T cell differentiation, function and survival
- Vaccination and the induction of T cell memory
Professional Bio
| 2009 - present |
Assistant Professor of Microbiology & Immunology University of Louisville School of Medicine Institute for Cellular Therapeutics |
| 2003 - 2009 |
Research Associate University of Louisville School of Medicine Institute for Cellular Therapeutics |
| 1999 - 2003 |
Postdoctoral Fellow, University of Louisville School of Medicine Institute for Cellular Therapeutics |
| 1996 - 1999 |
Postdoctoral Fellow in Clinical Studies University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA |
| |
Selected Publications
PM Chilton, CA Embry and TC Mitchell. Effects of differences in lipid A structure on TLR4 pro-inflammatory signaling and inflammasome activation. Frontiers in Immunology, 2012. 3:154 doi:10.3389/fimmu.2012.00154. PMID: 22707952.
SK Gandapudi, PM Chilton and TC Mitchell. TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion. PLoS ONE, 2013. 8: e56855 doi:10.1371/journal.pone.0056855.
M. Mühlbauer, PM Chilton, TC Mitchell and C Jobin. Impaired Bcl3 up-regulation leads to enhanced LPS-induced IL-23p19 gene expression in IL-10-/- mice. Journal of Biological Chemistry, 2008; 283:14182-9. PMID: 18375954.
V Mata-Haro, C Cekic, M Martin, PM Chilton, CR Casella and TC Mitchell.. The vaccine adjuvant monophosphoryl Lipid A as a TRIF-biased agonist of TLR4. Science, 2007; 316:1628-32. PMID: 17569868
S Sengupta, P Jayaraman, PM Chilton, CR Casella and TC Mitchell. Unrestrained GSK-3β activity leads to activated T cell death and can be inhibited by natural adjuvant. Journal of Immunology, 2007; 178:6083-91. PMID: 17475833
PM Chilton and TC Mitchell. CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen. Infection and Immunity, 2006; 74: 4180-9. PMID: 16790793.
PM Chilton, F Rezzoug, M Ratajczak, I Fugier-Vivier, J Ratajczak, M Kucia, Y Huang, MK Tanner and ST Ildstad. Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Blood, 2005; 105:2189-97. PMID: 15522953.
PM Chilton, F Rezzoug, I Fugier-Vivier, LA Weeter, H Xu, Y Huang, MB Ray and ST Ildstad. Flt3-ligand treatment prevents diabetes in NOD mice. Diabetes 2004; 53:1995-2002. PMID: 15277378.
RW Sweeney, J Uzonna, RH Whitlock, PL Habecker, P Chilton and P Scott.. Tissue predilection sites and effect of dose of Mycobacterium avium subs. paratuberculosis organism recovery in a short-term bovine experimental oral infection model. Res Vet Sci 2006; 80: 253-259. PMID: 16165171.
