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Paula M. Chilton, Ph.D.

by Eaves JR,Baxter Slaten last modified Dec 20, 2013 11:38 AM

Paula Chilton, Ph.D.

Assistant Professor, Dept. of Microbiology & Immunology

Ph.D. University of Louisville, 1996

B.S. Western Kentucky University 1991

 

Research Interests

  • Effects of low-toxicity TLR-based adjuvants on T cell differentiation, function and survival
  • Vaccination and the induction of T cell memory

 

Professional Bio

2009 - present 
Assistant Professor of Microbiology & Immunology University of Louisville School of Medicine Institute for Cellular Therapeutics
2003 - 2009
Research Associate University of Louisville School of Medicine Institute for Cellular Therapeutics
1999 - 2003
Postdoctoral Fellow, University of Louisville School of Medicine Institute for Cellular Therapeutics
1996 - 1999
Postdoctoral Fellow in Clinical Studies University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA
                              

 

Selected Publications

 PM Chilton, DM Hadel, TT To, TC Mitchell and RP Darveau.  Adjuvant activity of naturally-occurring monophosphoryl lipopolysaccharide preparations from mucosal-niche bacteria. Infection and Immunity, 2013. 81:3317-3325. doi:10.1128/IAI.01150-12. PMID:  23798540

PM Chilton, CA Embry and TC Mitchell. Effects of differences in lipid A structure on TLR4 pro-inflammatory signaling and inflammasome activation. Frontiers in Immunology, 2012. 3:154 doi:10.3389/fimmu.2012.00154.  PMID: 22707952.

SK Gandapudi, PM Chilton and TC Mitchell. TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion.  PLoS ONE, 2013. 8: e56855  doi:10.1371/journal.pone.0056855.   PMID: 23457630  http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0056855&representation=PDF 

M. M├╝hlbauer, PM Chilton, TC Mitchell and C Jobin.  Impaired Bcl3 up-regulation leads to enhanced LPS-induced IL-23p19 gene expression in IL-10-/- mice. Journal of Biological Chemistry, 2008; 283:14182-9.  PMID: 18375954.   http://www.jbc.org/content/283/21/14182.full.pdf+html

V Mata-Haro, C Cekic, M Martin, PM Chilton, CR Casella and TC Mitchell.. The vaccine adjuvant monophosphoryl Lipid A as a TRIF-biased agonist of TLR4.  Science, 2007; 316:1628-32.  PMID: 17569868 http://www.sciencemag.org/content/316/5831/1628.full.pdf

 S Sengupta, P Jayaraman, PM Chilton, CR Casella and TC Mitchell. Unrestrained GSK-3╬▓ activity leads to activated T cell death and can be inhibited by natural adjuvant. Journal of Immunology, 2007; 178:6083-91.  PMID: 17475833   http://www.jimmunol.org/content/178/10/6083.full.pdf+html

 PM Chilton and TC Mitchell. CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen.  Infection and Immunity, 2006; 74: 4180-9.  PMID: 16790793.    http://iai.asm.org/content/74/7/4180.full.pdf+html

 PM Chilton, F Rezzoug, M Ratajczak, I Fugier-Vivier, J Ratajczak, M Kucia, Y Huang, MK Tanner and ST Ildstad.  Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Blood, 2005; 105:2189-97.  PMID: 15522953.    http://bloodjournal.hematologylibrary.org/content/105/5/2189.full.pdf+html

 PM Chilton, F Rezzoug, I Fugier-Vivier,  LA Weeter, H Xu, Y Huang, MB Ray and  ST Ildstad.  Flt3-ligand treatment prevents diabetes in NOD mice. Diabetes 2004; 53:1995-2002. PMID: 15277378.   http://diabetes.diabetesjournals.org/content/53/8/1995.full.pdf+html

 RW Sweeney, J Uzonna, RH Whitlock, PL Habecker, P Chilton and P Scott..  Tissue predilection sites and effect of dose of Mycobacterium avium subs. paratuberculosis organism recovery in a short-term bovine experimental oral infection model.  Res Vet Sci 2006; 80: 253-259.  PMID: 16165171.     http://www.sciencedirect.com/science/article/pii/S0034528805001554#

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