Associate Professor of Microbiology and Immunology
Barnstable-Brown Chair in Diabetes Research
- Low toxicity adjuvant effects on T cells
- Mechanisms of activated T cell survival during immune responses
|2006 - present
||Associate Professor of Microbiology and Immunology University of Louisville School of Medicine Institute for Cellular Therapeutics
| 2000 - 2006
||Assistant Professor of Microbiology and Immunology University of Louisville School of Medicine Institute for Cellular Therapeutics
| 1995 - 2000
||Postdoctoral Research Fellow Howard Hughes Medical Institute National Jewish Medical and Research Center with John W. Kappler, Ph.D. and Philippa C. Marrack, Ph.D.
| 1993 - 1995
||Postdoctoral Research Fellow The McArdle Laboratory for Cancer Research The University of Wisconsin-Madison with Bill Sugden, Ph.D.
| 1986 - 1992
||Ph.D. (Cell and Molecular Biology) The University of Wisconsin-Madison with Rex Risser, Ph.D. (deceased) and Howard M. Temin, Ph.D. (deceased)
| 1982 - 1986
||B.S., with Honors and with High Distinction The University of Michigan
Mata-Haro V, Cekic C, Martin M, Chilton PM, Casella CR, and Mitchell TC. The Vaccine Adjuvant Monophosphoryl Lipid A as a Trif-biased Agonist of TLR4. Science, 2007; 316(5831):1628-1632.
Perspective on this paper published in Science, 2007; 316(5831):1574-1576.
Sengupta S, Jayaraman P, Chilton PM, Casella CR and Mitchell TC. Unrestrained glycogen synthase kinase-3beta activity leads to activated T cell death and can be inhibited by natural adjuvant.
The Journal of Immunology, 2007; 178(10):6083-91.
Chilton PM and Mitchell TC. CD8 T cells require Bcl-3 for maximal gamma interferon production upon secondary exposure to antigen.
Infection and Immunity, 2006; 74(7):4180-9.
Chilton PM, Jayaraman P, Cai M, Mitchell TC. Adjuvant-mediated effects on activated T cell survival and the divergent roles played by Bcl-3.
Research Signpost 2006, Vella A.T., editor.
Sengupta S, Chilton PM, and Mitchell TC. Adjuvant-induced survival signaling in clonally expanded T cells is associated with transient increases in pAKT levels and sustained uptake of glucose.
Immunobiology, 2005; 210(9):647-59.
Thompson BS, Chilton PM, Ward JR, Evans JT, and Mitchell TC. The low toxicity versions of LPS, MPL ® adjuvant and RC529, are efficient adjuvants for CD4 + T cells.
Journal of Leukocyte Biology, 2005; 78(6):1273-80.
Thompson BS, Mata-Haro V, Casella CR, and Mitchell TC. Peptide-stimulated DO11.10 T cells divide well but accumulate poorly in the absence of TLR agonist treatment.
European Journal of Immunology, 2005; 35(11):3196-3208.
Thompson BS and Mitchell TC. An in vivo method to determine the average survival of daughter cells following T cell activation.
J. Immunological Methods, 2004;295:79-87.
Hildeman DA, Mitchell T, Kappler J, Marrack P. T cell apoptosis and reactive oxygen species.
J. Clin. Invest., 2003; 111:575-81.
Hildeman DA, Mitchell T, Aronow B, Wojciechowski S, Kappler J, Marrack P. Control of Bcl-2 expression by reactive oxygen species.
Proc. Natl. Acad. Sci. USA , 2003;100:15035-40.
Hildeman DA, Zhu Y, Mitchell TC, Kappler J, Marrack P. Molecular mechanisms of activated T cell death in vivo.
Curr Opin Immunol. 2002;14(3):354-9.
Hildeman DA, Zhu Y, Mitchell TC, Bouillet P, Strasser A, Kappler J, Marrack P. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.
Immunity, 2002; 16(6):759-67.
Swanson BJ, Murakami M., Mitchell TC, Kappler J, and Marrack P. RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR dependent process.
Immunity, 2002; 17:605-615.
Mitchell TC , Thompson BS, Trent JO, and Casella CR. A short domain within Bcl-3 is responsible for its lymphocyte survival activity.
Ann. NY Acad. Sci., 2002; 975:132-147.
Mitchell TC , Teague KT, Hildeman DA, Bender J, Ress WA, Kedl RM, Swanson B, Kappler JW, and Marrack P. Stronger correlation of Bcl-3 than Bcl-2, Bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival.
Ann. NY Acad Sci., 2002; 975:114-131.
Schaefer B.C., Mitchell T.C ., Kappler J.W., Marrack P. A novel family of retroviral vectors for the rapid production of complex stable cell lines.
Anal Biochem., 2001; 297(1):86-93.
Mitchell TC, Hildeman D, Kedl RM, Teague TK, Schaefer BC, White J, Zhu Y, Kappler J, and Marrack P. Immunological adjuvants promote activated T cell survival via induction of Bcl-3.
Nature Immunology, 2001; 2(5):1-7.
Marrack P, Mitchell T, Hildeman D, Kedl R, Teague TK, Bender J, Rees W, Schaefer BC, Kappler J. Genomic-scale analysis of gene expression in resting and activated T cells.
Curr Opin Immunol 2000;12(2):206-9.
Hildeman DA, Mitchell T, Teague TK, Henson P, Day BJ, Kappler J, Marrack PC. Reactive oxygen species regulate activation-induced T cell apoptosis.
Mitchell T, Kappler J, Marrack P. Bystander virus infection prolongs activated T cell survival.
J Immunol. 1999;162(8):4527-35.
Marrack P, Kappler J, Mitchell T. Type I interferons keep activated T cells alive. J Exp Med.
Marrack P, Mitchell T, Bender J, Hildeman D, Kedl R, Teague K, Kappler
J. T-cell survival. Immunol Rev. 1998;165:279-85.