Hong Xu, M.D.

• Transplantation immunology
• Mixed hematopoietic chimerism to induce donor-specific tolerance
• Allogeneic sensitization in transplantation

2007 - presesnt	Assistant Professor, Department of Physiology & Biophysics, University of Louisville, KY
2001 - 2007	Research Immunologist, Institute for Cellular Therapeutics, University of Louisville, KY
1999 - 2001	Senior Research Assistant, Institute for Cellular Therapeutics, University of Louisville, KY
1997 -1999	Postgraduate Student, Surgical Research Laboratories, Department of Surgery, University of Queensland, Brisbane, Australia
1995 - 1997	Attending Surgeon, Hepatobilliary Unit, Department of Surgery, Sichuan Provincial Hospital, Chengdu, China
1994 - 1995	Chief Resident Surgeon. Department of Surgery, Sichuan Provincial Hospital, Chengdu, China
1988 - 1994	Resident Surgeon, Department of Surgery, Sichuan Provincial Hospital, Chengdu, China
1986 - 1988	Intern, Beijing Jishuitan Hospital, including three months research practice at Beijing Tumor Research Institute, Beijing, China

Xu H, Yan J, Huang Y, Chilton PM, Ding C, Schanie CL, Wang L, Ildstad ST.
Co-stimulatory blockade of CD154:CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization.
Blood. 2007 Sep 7;
http://www.ncbi.nlm.nih.gov/sites/entrez/17827394

Adamson LA, Huang WC, Breidenbach WC, Rahhal D, Xu H, Huang Y, Pidwell DJ, Wei FC, Tobin G, Ildstad ST.
A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts.
Microsurgery. 2007;27(7):630-6.
PMID: 17868137

Xu H, Chilton PM, Huang Y, Schanie CL, Yan J, Ildstad ST.
Addition of cyclophosphamide to T-cell depletion-based nonmyeloablative conditioning allows donor T-cell engraftment and clonal deletion of alloreactive host T-cells after bone marrow transplantation.
Transplantation. 2007 Apr 15;83(7):954-63.
PMID: 17460568

Xu H, Chilton PM, Tanner MK, Huang Y, Schanie CL, Dy-Liacco M, Yan J, Ildstad ST.
Humoral immunity is the dominant barrier for allogeneic bone marrow engraftment in sensitized recipients.
Blood. 2006 Nov 15;108(10):3611-9. Epub 2006 Aug 3.
PMID: 16888094

Huang Y, Kucia M, Rezzoug F, Ratajczak J, Tanner MK, Ratajczak MZ, Schanie CL, Xu H, Fugier-Vivier I, Ildstad ST.
Flt3-ligand-mobilized peripheral blood, but not Flt3-ligand-expanded bone marrow, facilitating cells promote establishment of chimerism and tolerance.
Stem Cells. 2006 Apr;24(4):936-48.
PMID: 16644924

Huang Y, Rezzoug F, Xu H, Chilton PM, Schanie CL, Fugier-Vivier I, Ildstad ST.
NK cells play a critical role in the regulation of class I-deficient hemopoietic stem cell engraftment: evidence for NK tolerance correlates with receptor editing.
J Immunol. 2005 Sep 15;175(6):3753-61.
PMID: 16148121

Fugier-Vivier IJ, Rezzoug F, Huang Y, Graul-Layman AJ, Schanie CL, Xu H, Chilton PM, Ildstad ST.
Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment.
J Exp Med. 2005 Feb 7;201(3):373-83.
PMID: 15699072

Xu H, Exner BG, Chilton PM, Schanie C, Ildstad ST.
CD45 congenic bone marrow transplantation: evidence for T cell-mediated immunity.
Stem Cells. 2004;22(6):1039-48.
PMID: 15536194

Ildstad ST, Chilton PM, Xu H, Domenick MA, Ray MB.
Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of alpha beta-TCR+ and CD4+ cells negates the effect.
Blood. 2005 Mar 15;105(6):2577-84. Epub 2004 Oct 21.
PMID: 15498851

Colson YL, Xu H, Huang Y, Ildstad ST.
Mixed xenogeneic chimerism induces donor-specific humoral and cellular immune tolerance for cardiac xenografts.
J Immunol. 2004 Nov 1;173(9):5827-34.
PMID: 15494536

Chilton PM, Rezzoug F, Fugier-Vivier I, Weeter LA, Xu H, Huang Y, Ray MB, Ildstad ST.
Flt3-ligand treatment prevents diabetes in NOD mice.
Diabetes. 2004 Aug;53(8):1995-2002.
PMID: 15277378

Xu H, Exner BG, Chilton PM, Tanner MK, Mueller YM, Rezzoug F, Ildstad ST.
A delay in bone marrow transplantation after partial conditioning improves engraftment.
Transplantation. 2004 Mar 27;77(6):819-26.
PMID: 15077020

Xu H, Chilton PM, Huang Y, Schanie CL, Ildstad ST.
Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism.
J Immunol. 2004 Feb 1;172(3):1463-71.
PMID: 14734723

Xu H, Exner BG, Cramer DE, Tanner MK, Mueller YM, Ildstad ST.
CD8(+), alphabeta-TCR(+), and gammadelta-TCR(+) cells in the recipient hematopoietic environment mediate resistance to engraftment of allogeneic donor bone marrow.
J Immunol. 2002 Feb 15;168(4):1636-43.
PMID: 11823491