Doctor of Philosophy in Anatomical Science and Neurobiology

Major: ASNBPHD
Degree Awarded: Ph.D.
Unit: GM
Program Webpage: http://louisville.edu/medschool/anatomy/

Program Information

Our philosophy is to encourage academic excellence in the neurosciences within a framework of structure-function relationships at the molecular, cellular, and systemic levels. We strive to prepare students with sufficient background depth to excel in high tech cutting-edge translational (applied) research environments and the more traditional multidisciplinary academic setting. We provide students with innovative approaches to important issues in neuroscience research including development, organization and plasticity. Our research interests range from sensory and motor systems to therapeutic strategies for spinal cord injuries. In all approaches we strive to integrate the latest teaching modalities while maintaining the time-honored advantages of hands-on, laboratory-based instruction.

The degree program is available to qualified individuals possessing a bachelor's degree from an accredited college or university. No specific undergraduate major is required, although some science background is required.

The Ph.D. degree is offered to students who plan to pursue a career in research and/or teaching, in an academic institution or within industry.

All degree programs require full-time study, and it is expected that while participating in these programs students will devote full-time effort toward completion of the degree requirements.

Program Admission Procedure

All students wishing to apply must submit an application to the Office of Graduate Admissions, School of Interdisciplinary and Graduate Studies, with the following documents:

  • A formal application submitted to the Office of Graduate Admissions (see website: http://louisville.edu/graduate/apply for forms and directions).
  • Application fee.
  • A minimum of two letters of recommendation.
  • Official transcripts of all college work.
  • Official scores on the Graduate Record Examination (GRE) General Test.
  • A brief statement of purpose describing your interests and career goals.
  • All international applicants whose native language is not English must submit Test of English as a Foreign Language (TOEFL) scores. Students holding a bachelor's or advanced degree from an accredited institution in the United States are exempt from this requirement.

Program candidates are only admitted in the fall semester (orientation begins the first Monday in August). Review of applications begins mid-January and continues until all positions are filled. Admission into the program is competitive, and applicants are encouraged to submit their applications early.  All applications are automatically considered for a fellowship, which provides a stipend and covers tuition and health insurance.

Curriculum

Non-thesis M.S. degree requirements

All Ph.D. students must complete the requirements for the non-thesis M.S. degree, after which they will be considered a Ph.D. candidate. A minimum of 30 semester hours is required for the Master’s degree of which 15 semester hours must be in courses of the major subject area. At least one-half of the credits counted toward the degree must be 600 level courses or above, excluding research credit hours. Courses with numbers from 500 to 599, open to both advanced undergraduate and graduate students, can be taken by graduate students for graduate credit (additional course requirements must be completed). In addition, up to 6 credits of earned graduate semester hours can be transferred upon request from other accredited institutions, as long as the course work was taken within the past three years and a grade of B or better was earned (transferred grades do not get calculated in the student’s GPA).

Required coursework

Integrated Programs in Biomedical Sciences (IPIBS) Course Requirements:

-  Students receiving a stipend from IPIBS must successfully complete all of the following courses within the School of Medicine:

Course #DescriptionCredit Hours
BIOC/CHEM 545Biochemistry I (or equivalent)3
BIOC 667Cell Biology (or equivalent)3
ASNB Course Requirements: 
ASNB 602
Fundamentals of Neuroscience4
BIOC 630
Research Ethics1
ASNB 610
Cellular and Molecular Immunology2
Students must earn at least 9 additional credits by successfully completing any of the following Departmental core courses: 
PHZB 605Systemic Physiology I5
PHZB 606Systemic Physiology II5
ASNB Course Requirements 
Students must earn at least 9 additional credits by successfully completing any of the following Department core courses:9
ASNB 601
Gross Anatomy 1 6.5
ASNB 603
Microscopic Anatomy 15
ASNB 605
Human Embryology 13
ASNB 617
Seminar on Developmental Neurobiology 13
ASNB 614
Molecular Neuroscience 14
ASNB 666
Synaptic Organization of the Central Nervous System 13
ASNB 671
General and Oral Histology5
ASNB 672
Survey of Dental Gross and Neuroanatomy 
ASNB 618Laboratory Rotation (2 lab rotations, see description below)6
ASNB 606Anatomy Seminar (must be taken for credit each semester prior to Master's Candidacy)1
Electives: 2  
NSCI 601Translational Neuroscience3
MBIO 602Introductory Immunology2
BIOCH/CHE 547Biochemistry II3
MBIO 658Cellular and Molecular Immunology3
PHY 605Physiology I3
PHY 606Physiology II3
Minimum Total Hours37-39

 Footnotes

1

Offered on a rotational basis

2

Additional courses (electives) within ASNB or graduate level courses in other departments may be taken to achieve the minimum requirement of 30 credit hours. The student should consult with his/her advisor on the selection of the appropriate electives. A course in statistics is highly recommended.

Exceptions that may require different course work will be reviewed on a case by case basis by the ASNB Graduate Committee.

Laboratory Rotations and Research Hours

Lab Rotations: Each student will complete two rotations in different laboratories prior to start of their third semester. Exceptions or the addition of a third rotation require approval from the ASNB Graduate Committee. The objectives of rotations in 2 labs are to expose the student to different approaches and areas of research, and to assist the student in choosing a laboratory for dissertation research. For each rotation, the student will register for the 3 credit course Laboratory Rotation (ASNB 618) which is graded on a pass/fail basis. Once a student has completed a semester rotation in a given laboratory, an ASNB Rotation Report must be completed and submitted to the Graduate Program Director.

Research Hours: Once a mentor is chosen, research hours are taken as Original Investigation (ASNB 619), in which students earn a letter grade.

The purpose of the advisory committee is to act as the primary guiding and assessment body for the student in a course of study and training through which they will acquire the knowledge and skills required to earn the degree of Doctor of Philosophy. The course of study and training will have components that are common for all students, but may have others that are tailored to the particular needs and/or desires of individual students.

The committee must have a minimum of five members. The Principal Advisor serves as chair. The majority of committee members must have a primary, joint or associate appointment in ASNB. At least one member must have a primary appointment in a department outside ASNB (this outside committee member must not have a joint appointment in ASNB) and can include a Graduate Faculty from another University. The student, in conjunction with the advisor, should form a committee prior to the start of the second year. Once the committee is formed, the student will meet with the committee at least twice per year. A Graduate Student Progress Report, completed by the Advisor, must be filed semi-annually (at the end of the fall and spring semesters) with the ASNB Graduate Program Director. Registration for courses is contingent on this filing.

Masters Candidacy

After completion of all course requirements, students must register for and maintain candidacy (MAST 600) until the successful completion of his/her qualifying exam.  This registration must be maintained year-round (fall, spring, and summer). Once a student registers for MAST 600, he/she may not register for additional courses.

Qualifying Exam

The purpose of the qualifying exam is to assure that the student has sufficient knowledge and skills to begin a research project. The exam will be taken within two terms (summer term included) after the successful completion of required coursework but no later than the Spring semester of Year 3.

Each member of the student’s Advisory Committee will prepare one question designed to assess the student’s ability to integrate course material, demonstrate critical thinking, and evaluate the literature related to the student’s area of interest.  The student’s mentor will submit all the questions (minimum of five) to the Graduate Program Director.  The ASNB Graduate Committee will review the questions and select three for distribution to the student.  The student will have one week to complete two of the three questions (of their own choosing) and submit the answers electronically (pdf format) to the Graduate Program Director. The exam is “open-book” and must be written in the student’s own words.  The answers represent the student’s unaided efforts and should NOT be edited or critiqued in any form by anyone other than the student, including the mentor, the student’s committee, or other trainees in the program. The answer to each question should be no less than 10 pages and no more than 20 pages in length, double-spaced, not including references. The use of books and review articles is acceptable; however, a significant portion of the paper must be based on recent, primary sources in scientific journals.

The submitted answers will be evaluated by two members of the ASNB Graduate Committee plus one representative from the student’s advisory committee, excluding the mentor. Each answer will be evaluated on a scale from 1 (poor) to 10 (outstanding) on mastery of basic background and conceptual material, familiarity with the literature in the field of study and critical thinking about the cited works and scientific question. In order to pass the qualifying exam and continue in the Ph.D. program, the student must 1) receive a minimum total score of at least 12 out of 20 and 2) receive at least a score of 5 on each question.  A student who does not meet these passing requirements will have one chance for remediation. The remedial examination must be completed no later than 6 months after the student completed the original examination.  The exam will again be comprised of answering two questions in the same format; the third question that had been submitted to the student by the ASNB Graduate Committee that was not answered plus a new question. Failure after remediation will result in dismissal from the Ph.D. program.

Upon successful completion of the exam, an evaluation form stating the outcome of the exam will be completed and signed by each committee member and will become a permanent part of the student’s record. A passing grade indicates that the student has completed the requirements for an M.S. degree. At this point, the student becomes a doctoral candidate and must register for and maintain candidacy (DOCT 600) until the successful completion of his/her dissertation.  This registration must be maintained year round (Fall, Spring, and Summer). The statute of limitation for obtaining a Ph.D. degree at the University of Louisville is four years from the beginning of Doctoral Candidacy. University-wide official maximums for Fellowships and Graduate Assistantships are typically 6 years.

Research Proposal

The Research Proposal should be defended in the semester following successful completion of the Qualifying Exam but not later than the Fall semester of Year 4.  Prior to writing the Research Proposal, the student will develop an outline of the proposed experiments in coordination with their advisor and then present this outline to their committee.  It is at this point, prior to writing the Research Proposal that the committee should recommend any changes in the research plan, regarding, for example, the number of experiments, reducing the difficulty of experiments, or introducing experiments that may be more appropriate for addressing the research question. Once the committee is satisfied with the proposed experiments, the student will write a Research Proposal in the following general format.*

Literature Review and Significance

Section one will be an extensive literature review (similar to an expanded Background and Significance section of a National Institutes of Health grant proposal). This review should provide evidence that the student has a sufficient command of the background information relevant to the proposed research.

Specific Aims, Hypotheses, and Experiments

This section will consist of a list of the proposed specific aims. Each Aim should include hypotheses to be tested and a brief description of the experiments that will be used to test these hypotheses.

Experimental Design and General Methods

This section will consist of a detailed description of the experimental design as well as the methods that will be used to carry out the proposed experiments.

Expected Outcomes

This section will describe the expected results and how they will be interpreted.

Potential Problems

This section will describe any potential problems that could occur, how they might affect interpretation of their research results, and how the student will address any potential problems.

*All eligible students are encouraged to submit (in coordination with their advisor) an application for a National Institutes of Health Predoctoral National Research Service Award (F31) or a National Science Foundation Predoctoral Award. Therefore, the Research Proposal may be submitted in the format of a relevant application with the exception that the background and significance section should be expanded to include a more extensive literature review than permitted by the NIH or NSF page limitations.

Upon completion of the research proposal, the student will distribute a copy to each committee member, who will have no less than two weeks to read the proposal. Students must consider this two week reading period when preparing the document and scheduling the exam. The proposal defense itself will be chaired by the student’s advisor. The defense will begin with an oral presentation, open to the public, in which the student will present an overview (approximately 40 min) of their research plan. The presentation will be followed by an oral defense to assess the student’s readiness to conduct the proposed research. Non-committee members in the audience will have an opportunity to ask questions first. The general audience will then be dismissed and the student will defend his/her proposal before the committee. Success or failure will be determined by majority vote of the committee. A student who fails the exam will have 2 months to retake the exam. Failure on the second attempt will result in dismissal from the program. Upon successful completion, a Proposal Defense Evaluation Form stating the outcome will be completed and signed by each committee member and will become a permanent part of the student’s record.

Annual presentation of research progress

Ph.D. students who have completed their classwork (M.S. and Ph.D. candidates) must present their research accomplishments annually. This presentation should be 30-50 minutes in length, and time and location of the presentation should be formally announced to the department faculty, staff and students at least one week prior to the planned presentation. Presentations at journal clubs are encouraged, but cannot be used as a substitute for the annual presentation requirement.

Teaching requirements

Each Ph.D. candidate must serve as a teaching assistant (T.A.) in at least one ASNB core course. The specific course will be chosen, based on available TA slots, by the student and his/her advisory committee.

Dissertation Defense

With the exception of their training in teaching, the Ph.D. candidate will focus exclusively on completing their research projects and writing a dissertation describing the results of their experiments. The candidate must complete all requirements for the degree of Doctor of Philosophy within four calendar years after passing the qualifying examination. It is expected that the dissertation should contain data sufficient for approximately three publishable manuscripts. Upon completion of a near final draft of their dissertation and prior to scheduling of their defense, the student must distribute a copy to each Dissertation Committee member. The committee will have two weeks to read a preliminary draft of the dissertation and give approval to schedule a defense date or recommend major changes that need to be completed prior to scheduling a defense date.

Once the dissertation is approved to move forward by the committee, the student will schedule a Dissertation Defense and distribute an edited copy to each committee member. SIGS requires that an announcement of the defense be made at least two weeks prior to the scheduled date. The defense will consist of a public oral presentation (approximately 45 minutes in length) of the research completed during the student’s graduate training. Non-committee members in the audience will be allowed to ask questions. The general audience will then be dismissed and the student will defend his/her dissertation before the committee. Upon completion, a written report stating the outcome of the defense will be completed by each committee member and will become a permanent part of the student’s record. Approval by the majority of Dissertation Committee members will signify successful completion of the Ph.D. degree.

Electronic Format of Dissertation

Deadlines for the submission are published online in the schedule of classes. Students must follow The School of Interdisciplinary and Graduate Studies (SIGS) requirements for the format of their Doctoral Dissertation. The published Guidelines for the Preparation and Processing of Theses/Dissertations can be found at https://graduate.louisville.edu/Programs/theses-dissertations/Thesis_Dissertation%20Guidelines.pdf. Any dissertation received by SIGS that does not adhere to their guidelines will be returned to the student.

SIGS requires the submission of a digital dissertation. The digital document must be submitted in Adobe PDF format. The electronic version should not include signatures from the dissertation advisory committee. It should list the committee members’ names only. Students must submit a hard copy of their signature page on white paper, with original signatures, to SIGS. If students wish to use in their dissertation material that has been previously published under their names, they will need to contact the original publisher for permission. It is the student’s responsibility to provide to ASNB the required bound copy of the finalized dissertation. For archival purposes, it is required that the document is printed on 25% cotton paper.

Academic policies

General Program Requirements

Students should familiarize themselves with the general requirements for the Master’s and Ph.D. Degrees as stated in the current University of Louisville Graduate Catalog (http://louisville.edu/graduate). The award of a Doctor of Philosophy degree indicates that a student has attained mastery of a field and has demonstrated the capacity to perform independent scholarly research, including the ability to think critically. The doctoral degree is not awarded solely upon completion of a curriculum of courses, even though the student has done superior work in them; rather, it is awarded in recognition of creative scholarship in the candidate's chosen field.

All Ph.D. students receiving financial support from the University of Louisville, including University Fellows and Graduate Assistants, must be enrolled as full-time students during the period for which they are receiving support. The minimum and maximum number of credit hours for full-time study are 9 and 12, respectively, in the fall and spring semesters (6 and 12 for the summer). To be considered in good standing, a grade average of 3.0 or better must be maintained. The program faculty and unit dean monitor the GPA of every graduate student.  A student must be in good standing to receive a degree. Students must be enrolled during the semester in which they wish to graduate.

Academic Probation

Any student with a point standing below 3.0 will be placed on academic probation until the student regains a 3.0 average or is dismissed. Students are ordinarily not permitted to continue on academic probation for more than one semester. Upon request of the student's graduate program, the unit dean may approve continuation beyond a single semester. A student who has received the grade of "C" (in a course that is a degree requirement), "D" or "F" may repeat that course upon the approval of the graduate program director and the unit dean. When a student repeats a course, the grade point average will be calculated on the basis of the last grade earned, although all previous grades will remain on the transcript.

Administration

For administrative purposes, an interim Ph.D. Advisor will be assigned to each incoming student until he/she has selected a Dissertation Mentor.

Guideline Changes

The Department reserves the right to change requirements at any time. When requirements change, the student may have the option of satisfying either the requirements in effect when he/she entered the program or the new requirements, depending on circumstances.

Faculty

William Guido

Professor - Chairman

Martha E. Bickford

Professor - Course Director, Synaptic Organization of the Brain

Jennifer Brueckner-Collins

Professor; Course Director, Medical Gross Anatomy

Nigel G.F. Cooper
Professor

Director, Molecular Neurobiology Core Laboratory

Charles H. Hubscher
Professor - Vice Chair and Director of Graduate Studies

Robin F. Krimm
Professor - Vice Chair for Research
Course Director, Developmental Neurobiology

Ashok Kumar
Professor
Course Director, Molecular Neurobiology
Matthew Qiu
Professor

Director, Neurochemistry Shared Instrumentation Laboratory

Guillermo W. Rougier

Professor

Michael T. Tseng
Professor

Course Director, Dental Microscopic Anatomy

Rita M. Colella
Associate Professor

Course Director, Medical Microscopic Anatomy

Nobuyuki Kuwabara
Associate Professor

Facilitator for Guest Clinical Gross Anatomy Instructors

Robert F. Lundy, Jr.
Associate Professor

Course Director, Medical Neurosciences and Fundamentals of Neuroscience

J. Patrick Moore
Associate Professor

Director of Graduate Admissions

Jeffrey C. Petruska

Associate Professor

Richard Benton

Assistant Professor

Bart Borghuis

Assistant Professor

Nicole R. Herring
Assistant Professor
Course Director, Advanced Head and Neck Anatomy and Survey of Dental Gross & Neuroanatomy

Director, Fresh Tissue Laboratory and Bequeathal Program

Aaron McGee

Assistant Professor

Chad Samuelson
Assistant Professor

Joint/Associate Appointments

Susan Harkema
Professor - Neurological Surgery

Research Director, Frazier Rehab Institute

David Magnuson

Professor - Neurological Surgery

Maureen McCall

Professor - Ophthalmology and Visual Sciences

Scott Whittemore
Professor  - Neurological Surgery

Scientific Director, Kentucky Spinal Cord Injury Research Center

Maxwell Boakye

Associate Professor - Neurological Surgery

Dena Howland

Associate Professor - Neurological Surgery

Patrick Scott

Assistant Professor - Ophthalmology and Visual Sciences

Teresa Pitts

Assistant Professor - Neurological Surgery

David Stirling

Assistant Professor - Neurological Surgery