Recent Publications
McNeely, SC, Taylor, BF, and States, JC. Sodium
Arsenite Causes BubR1-Dependent Mitotic Arrest-Associated Apoptosis in A375
Melanoma Cells. Toxicology and Applied Pharmacology 231:61-67 (2008)
doi:10.1016/j.taap.2008.03.020
Taylor, BF, McNeely, SC, Miller, HL and States, JC. Arsenite-induced mitotic death involves stress response and is independent of tubulin polymerization.Toxicology and Applied Pharmacology 230:235-246 (2008) doi:10.1016/j.taap.2008.02.030
McNeely, SC, Belshoff, AC, Taylor, BF, Fan, TW, McCabe, Jr., MJ, Pinhas, AR and States, JC. Sensitivity to Sodium Arsenite in Human Melanoma Cells Depends upon Susceptibility to Arsenite-Induced Mitotic Arrest. Toxicology and Applied Pharmacology 229, 252-261 (2008) doi:10.1016/j.taap.2008.01.020
Arteel, GE, Guo, L, Schlierf, T, Beier, JI, Kaiser, JP, Chen, TS, Liu, M, Conklin, DP, Miller, HL, von Montfort, C and States, JC. Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice. Toxicology and Applied Pharmacology 226:128-39 (2008)
Husain, A, Zhang, X, Doll, MA, States, JC, Barker, JC and Hein, DW. Functional Analysis of the Human N-Acetyltransferase 1 Major Promoter: Quantitation of Tissue Expression and Identification of Critical Sequence Elements. Drug Metabolism and Disposition 35:1649-1656 (2007)
Bendaly, J, Zhao, S, Neale, JR, Metry, KJ, Doll, MA, States, JC, Pierce, WM, Jr. and Hein, DW. MeIQx-induced DNA adduct formation and mutagenesis in DNA repair deficient CHO cells expressing human CYP1A1 and rapid or slow acetylator NAT2. Cancer Epidemiology, Biomarkers & Prevention 16:1503-1509 (2007)
Zang, Y, Doll, MA, Zhao, S, States,
JC and Hein, DW. Functional Characterization of Single Nucleotide Polymorphisms
and Haplotypes on Human N-Acetyltransferase 2.
Carcinogenesis 28(8):1665-1671 (2007)
Husain, A, Zhang, X, Doll, MA, States, JC, Barker, JC and Hein, DW. Identification of N-Acetyltransferase 2 (NAT2) Transcription Start Sites and Quantitation of NAT2-specific mRNA in Human Tissues. Drug Metabolism and Disposition 35: 721-727 (2007)
Srivastava, S, D’Souza, SE, Sen, U and States, JC. In utero arsenic exposure induces early onset of atherosclerosis in ApoE-/- mice. Reproductive Toxicology (special issue Fetal Basis of Adult Disease) 23:449-56 (2007)
Metry, KJ, Zhao, S, Neale, JR, Doll, MA, States, JC, McGregor, WG, Pierce,Jr, WM and Hein, DW. “2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine - induced DNA adducts and genotoxicity in Chinese Hamster Ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2” Molecular Carcinogenesis 46:553-563 (2007)
O’Brien TJ, Jiang G, Chun G, Mandel HG, Westphal C, Kahen K, Montaser A, States JC and Patierno SR. “Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease” Mutation Research / Genetic Toxicology and Environmental Mutagenesis 610:85-92 (2006)
McNeely SC, Xu X, Taylor BF, McCabe, Jr. MJ, Zacharias W and States JC. “Exit from arsenite induced mitotic arrest is p53-dependent” Environmental Health Perspectives – Toxicogenomics 114:1401-1406 (2006)
Jiang GH, Skorvaga M, Croteau DL, Van Houten B
and States JC. Robust Incision of Benoz[a]pyrene-7,8-dihyrodiol-9,10-epoxide-DNA
Adducts by a Recombinant Thermoresistant Interspecies Combination UvrABC
Endonuclease System. Biochemistry
45:7834-7843 (2006)
Taylor BF, McNeely SC, Miller HL, Lehmann GM, McCabe Jr MJ and States JC. P53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1. J Pharmacol Exp Ther. 318(1):142-151 (2006)
Barker DF, Husain A, Neale JR, Martini BD, Zhang X, Doll MA, States JC and Hein DW. “Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1” Pharmacogenetics and Genomics 16:515-525 (2006)
Porter PC, Clark DR, McDaniel LD, McGregor WG and States JC. “Telomerase immortalized human fibroblasts retain UV-induced mutagenesis and p53 mediated DNA damage responses”, DNA Repair 5:61-70 (2006) doi:10.1016/j.dnarep.2004.10.007
Jiang, G, Skorvaga, M, Van Houten, B and States, JC. "Reduced sulfhydryls maintain specific incision of BPDE-DNA adducts by recombinant thermoresistant B. caldotenax UvrABC endonuclease", Protein Expression and Purification 31:88-98 (2003)
Mellon, I, Hock, T, Reid, R, Porter, PC and States, JC "Polymorphisms in the human Xeroderma Pigmentosum Group A Gene and Their Impact on Cell Survival and Nucleotide Excision Repair", DNA Repair 1: 531-546 (2002)
States, JC, Reiners, JJ, Jr., Pounds, JG, Kaplan, DJ, Beauerle, BD, McNeely, SC, Mathieu, P and McCabe, MJ, Jr "Arsenite Disrupts Mitosis and Induces Apoptosis in SV40-Transformed Human Skin Fibroblasts", Toxicol. Appl. Pharmacol. 180: 83-91 (2002) medline
Lu, Y, Mani, S, Kandimalla, ER, Yu, D., Agrawal, S, States, JC and Bregman, DB "Targeting the Cockayne Syndrome Group B Protein with Antisense Oligonucleotides Sensitizes Ovarian Carcinoma Cells to Cisplatin, Oxaliplatin, or Ionizing Radiation", Internatl. J. Oncol. 19: 1089-1097 (2001). medline
States, JC, McGregor, WG and Ljungman, M "2nd Annual Midwest DNA Repair Symposium, University of Louisville, Louisville, KY, 20-21 May 2000" Mutation Research - DNA Repair 461, 163 -167 (2000).
McCabe, MJ, Jr, Singh, K, Reddy, SA, Chelladurai, B, Pounds, JC, Reiners, JJ, Jr and States, JC "Sensitivity of Myelomonocytic Leukemia Cells to Arsenite-induced Cell Cycle Disruption, Apoptosis and Enhanced Differentiation on the Inter-Relationship between Arsenic concentration, duration of treatment and cell cycle phase", J. Pharmacol. Exp. Therap. 295: 724-733 (2000).
Waalkes, MP, Fox, DA, States, JC, Patierno, SR and McCabe, MJ Jr, " Metals and Disorders of Cell Accumulation: Modulation of Apoptosis and Cell Proliferation ", Toxicolog. Sci. 56: 255-261 (2000).
Cleaver, JE, Thompson, LH, Richardson, AS and States, JC, "A Summary of Mutations in the UV-sensitive Disorders: Xeroderma Pigmentosum, Cockayne Syndrome, and Tricothiodystrophy", Human Mutation 14: 9-22 (1999)[PubMed citation]
States, JC, McDuffie, ER, Myrand, SP, McDowell, M and Cleaver, JE, "Distribution of Mutations in the Human Xeroderma Pigmentosum Group A Gene and Their Relationships to the Functional Regions of the DNA Damage Recognition Protein", Human Mutation 12: 103-113 (1998) [PubMed citation]
Cleaver, JE and JC States, "The DNA Damage Recognition Problem in Human and other Eukaryotic Cells: the XPA Damage Binding Protein", [ Biochem. J., 328: 1-12 (1997).] [ PubMed citation]
Kuhn DM, Arthur R Jr, States JC, "Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A" [ J Neurochem 68:2220-2223 (1997) (PubMed)].
States, J.C. and Myrand, S.P., "Splice Site Mutations in a Xeroderma Pigmentosum Group A Patient with Delayed Onset of Neurological Disease",[Mutation Research 363:171-177 (1996) (PubMed)].
Myrand, S.P., Topping, R.S. and States, J.C., "Stable transformation of xeroderma pigmentosum group A cells with an XPA minigene restores normal DNA repair and mutagenesis of UV-treated plasmids" [Carcinogenesis 17:1907-1919 (1996) (PubMed)].
D'Sa, C., Arthur, R., States, J.C. and Kuhn D.M., "Tryptophan Hydroxylase: Cloning and Expression of the Native Brain Enzyme in Mammalian Cells",[ J. Neurochem. 67:900-906 (1996) (PubMed)].
States, J.C. and Reed, E., "Enhanced XPA mRNA levels in cisplatin-resistant human ovarian cancer are not associated with XPA mutations or gene amplification" [Cancer Letters 108:233-237 (1996) (PubMed)].
Quan, T.H. and States, J.C. 1996. "Preferential DNA Damage in p53 gene by benzo(a)pyrene metabolites in CYP1A1-expressing xeroderma pigmentosum group A cells" [Molecular Carcinogenesis 16:32-43 ]
Quan, T.H., Reiners, J.J., Culp, S.J., Richter, P., and States, J.C., "Differential mutagenicity and cytotoxicity of (+/-)-benzo(a)pyrene-trans-7,8- dihydrodiol and (+/-)-anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts." [ Mol. Carcinogenesis 12:91- 102 (1995) (PubMed)].
Topping, R.S., Myrand, S.P., Williams, B.L., Albert, J.C., and States, J.C., "Characterization of the human XPA promoter." [ Gene 166:341-342 (1995) (PubMed)].

