Overview of Research Interests



Research in the Grapperhaus Group focuses on the inorganic and bioinorganic chemistry of  transition metal-thiolates. Transition metal-thiolates display variable reactivities that are dependent on the identity of the metal, the thiolate substituent group, and the covalency of the metal-sulfur bond. Our research seeks to identify and exploit these factors for the design of systems with synthetic or industrial utility.


Our current research efforts are focused on the following projects:

Synthetic Models of Nitrile Hydratase

Metal-Stabilized Thiyl Radicals