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Integrative Health Sciences Facility Core (IHSFC)

The central goal of the Integrative Health Sciences Facility Core (IHSFC) is to provide investigators in the Center for Genomics and Integrative Biology (CEGIB) with services and consultation that facilitate translation of basic research findings into clinical or public health applications.


The IHSFC brings together basic, clinical and public health researchers to address research focused on translation of basic discoveries to human applications. These efforts are supported in part by the Public Health Research Center (PHRC) which provides examination and phlebotomy rooms, testing facilities, a conference room, and laboratory space for sample pre-processing. Our partnership with the Louisville Metro Department of Public Health and Wellness (LMPHW) and our alignment with its vision, provide unique access to environmentally impacted communities for translational research. These facilities are complementary to the clinical facilities utilized by CEGIB members for pulmonary, preventive cardiovascular medicine and other consultations. Core expertise includes: biochemistry and molecular biology; molecular diagnostics and biomarker discovery and development; clinical chemistry and pharmacology; immunology and molecular epidemiology; ethical, legal and social issues in environmental health research; regulatory compliance; and technology transfer.

IHSFC Services Include: 

  • Access to key technologies to facilitate biomarker discovery, development and application
  • Access to outpatient clinical facilities, including the PHRC and UofL outpatient clinics in disciplines such as cardiology and pulmonary medicine
  • Clinical and public health study design
  • Human subjects, HIPAA, blood borne pathogens, and other regulatory compliance
  • Ethical, Legal and Social Implications (ELSI) research support services
  • Facilitate the Interface of researchers with community-based organizations and agencies that impact clinical and public health research in the region

Biomarker Development Process    Biomarker Development Process

The primary goal for the IHSFC core is to guide and assist the CEGIB investigators through the stages of of biomarker development, validation and implementation.  For instance, in the discovery phase, the investigator may need to develop an ELISA assay to see if plasma collected from patients with a particular disease or condition display the changes observed in cell culture experiments.  However, investigators may approach the IHSFC for issues related primarily to study design and needs associated with ascertainment and recruitment of study subjects. On the other hand, a project might be at a later stage and require commercialization and clinical implementation assistance. 

Biomarker Validation

Antibody-based assays such as ELISA and those using bead multiplex systems are well-suited for validation studies when suitable antibody pairs are available.  New mass spectrometry-based techniques play a valuable role in validation studies when antibody pairs are now available.

Long Term Accomplishments

A bench-to-bedside comprehensive research program was implemented addressing critical issues in environmental health. Clinical samples from myocardial infarction, cancer and inflammatory bowel disease studies are being utilized under the auspices of the IHSFC.


Training experience available to Junior Investigators include hands-on training, one-on-one training in quality control, genomic, proteomic and metabolomic technologies, as well as training in clinical practices, and ethical, legal and social services. The IHSFC provides periodic lectures and workshops to Junior Investigators, members of CEGIB and the University.


IHSFC Home (link) 

CEGIB Home (link)

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