Sustained Adipose Tissue Inflammation in Obesity


Hellmann diagramDiabetes and obesity are associated with chronic low-grade inflammation and insulin resistance. Our recent work has uncovered that nutrient excess delays resolution of acute inflammation. Importantly, promoting resolution with pro-resolving lipid mediators restores insulin sensitivity and enhances diabetic wound healing.

Based on these observations, we are interested in understanding mechanisms by which innate and adaptive immune responses promote adipose tissue inflammation and insulin resistance.

Completion of this project will help identify cellular mechanisms that propagate chronic unresolved adipose tissue inflammation in obesity and diabetes, providing new therapeutic targets for the treatment of T2D.

Related Publications


Principal Investigator

Jason Hellmann, Ph.D.

Jason Hellmann, Ph.D.

Assistant Professor of Medicine

Education

  • Ph.D.: Physiology, University of Louisville, Louisville, KY

  • Postdoc: University of Louisville, Louisville, KY / Brigham and Women’s Hospital-Harvard Medical School, Boston, MA

Research Focus

  • Role of lipid mediators in resolution of inflammation in cardiometabolic disease

  • Innate and adaptive immunity in adipose tissue inflammation in obesity

  • Exercise induced changes in inflammatory responses